Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation

Singh, Ashok K.; Raj, Vinit; Keshari, Amit K.; Rai, Amit; Kumar, Pranesh; Rawat, Atul; Maity, Biswanath; Kumar, Dinesh; Prakash, Anand; De, Arnab; Samanta, Amalesh; Bhattacharya, Bolay; Saha, Sudipta

doi:10.1016/j.cbi.2017.12.007

Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation

In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. SA1 and SA2 were orally administered to streptozot…