Hydrolysis of dibutyl phthalate and di(2-ethylhexyl) phthalate in human liver, small intestine, kidney, and lung: an in vitro analysis using organ subcellular fractions and recombinant carboxylesterases

Isobe, Takashi; Ohkawara, Susumu; Mori, Yoko; Jinno, Hideto; Tanaka-Kagawa, Toshiko; Hanioka, Nobumitsu

doi:10.1016/j.cbi.2023.110353

Hydrolysis of dibutyl phthalate and di(2-ethylhexyl) phthalate in human liver, small intestine, kidney, and lung: an in vitro analysis using organ subcellular fractions and recombinant carboxylesterases

Phthalates are widely used plasticizers that are primarily and rapidly metabolized to monoester phthalates in mammals. In the present study, the hydrolysis of dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) in the human liver, small intestine, kidney, and lung was examined by the ca…