Designing synthetic materials to control stem cell phenotype
Open accessAbstract
The micro-environment in which stem cells reside regulates their fate, and synthetic materials have recently been designed to emulate these regulatory processes for various medical applications. Ligands inspired by the natural extracellular matrix, cell-cell contacts, and growth factors have been incorporated into synthetic materials with precisely engineered density and presentation. Furthermore, material architecture and mechanical properties are material design parameters that provide a context for receptor-ligand interactions and thereby contribute to fate determination of uncommitted stem cells. Although significant progress has been made in biomaterials development for cellular control, the design of more sophisticated and robust synthetic materials can address future challenges in achieving spatiotemporal control of cellular phenotype and in implementing histocompatible clinical therapies.
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Synthetic hydrogels can be functionalized with biologically active moieties that permit the growth and spread of cells; concentration and spacing of these cues can be changed independently.
“Synthetic hydrogels can be functionalized with biologically active moieties that permit the growth and spread of cells146–151; concentration and spacing of these cues can be changed independently152–155.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [148]
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References 60 · Cited by 219
- Authors
- Saha, K., Pollock, J. F., Schaffer, D. V., & Healy, K. E.
- Affiliations
- University of California, Berkeley (US)
- University of California, San Francisco (US)
- Corresponding author
- Schaffer, David V
- Healy, Kevin E
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 11
- Issue
- 4
- Pages
- 381-387
- ISSN
- 1367-5931 (ISSN-L)
- PMC
- PMC1993842
- OpenAlex
- W2048336231
- Cited by
- 219
- References
- 60
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 1 · 2019: 7 · 2018: 11 · 2017: 17 · 2016: 17 · 2015: 11 · 2014: 19 · 2013: 22 · 2012: 17
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R21NS048248, NS048248)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR43187, R01AR043187)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- stem cell fate determination, synthetic biomaterials, extracellular matrix mimics, material architecture, mechanical properties, ligand-receptor interactions, spatiotemporal control, histocompatibility
- MeSH terms
- Animals, Humans, Ligands, Phenotype, Stem Cells, Cell Culture Techniques
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