Wnt/β-catenin signaling participates in the regulation of lipogenesis in the liver of juvenile turbot (Scophthalmus maximus L.)
Abstract
In this study, the mechanism that Wnt/β-catenin signaling inhibits lipogenesis was investigated in the liver of juvenile turbot (Scophthalmus maximus L.) by LiCl or XAV939 treatment. Wnt/β-catenin signaling was activated by LiCl treatment or inhibited by XAV939 treatment through regulating the expression of glycogen synthase kinase-3β (GSK-3β) and Wnt10b. In addition, the expression of lipoprotein lipase (LPL), fatty acid synthetase (FAS), peroxisome proliferator-activated receptor γ (PPARγ), and CCAAT/enhancer binding protein α (C/EBPα) was inhibited by LiCl treatment, but induced by XAV939 treatment. In the plasma of juvenile turbot, the level of nonesterified fatty acid (NEFA), glycerol, triglyceride (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C) was decreased by LiCl treatment, which was related to the decrease of the activity of LPL and FAS. Thus the inhibitory effect of Wnt/β-catenin signaling on lipogenesis was associated with the expression of key enzymes and transcriptional factors. Wnt/β-catenin signaling may participate in inhibiting lipogenesis by inhibiting the expression of PPARγ and C/EBPα in the liver of juvenile turbot.
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XAV-939, a Wnt signaling antagonist, reportedly suppresses the expression of glycogen synthase kinase-3β and Wnt10b.
“XAV-939, a Wnt signaling antagonist, reportedly suppresses the expression of glycogen synthase kinase–3β and Wnt10b (36).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [36]
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References 40 · Cited by 15
- Authors
- Liu, D., Mai, K., Zhang, Y., Xu, W., & Ai, Q.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Ai, Qinghui
- Venue
- Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 191
- Pages
- 155-162
- ISSN
- 1096-4959 (ISSN-L)
- OpenAlex
- W1914822219
- Cited by
- 15
- References
- 40
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31172425, 31372541)
- Ministry of Education of the People's Republic of China (20120132110007)
- Agriculture Research System of China (CARS-50-G08)
- National Key Research and Development Program of China (2014CB138600)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- Wnt/β-catenin signaling, lipogenesis, liver, turbot, juvenile fish, glycogen synthase kinase-3β, Wnt10b, lipoprotein lipase, fatty acid synthase, PPARγ, C/EBPα, lipid metabolism, free fatty acids, triglycerides, cholesterol, LDL-C
- MeSH terms
- Animals, Flatfishes, Heterocyclic Compounds, 3-Ring, Liver, Gene Expression Regulation, Enzymologic, Lithium Chloride, CCAAT-Enhancer-Binding Protein-alpha, PPAR gamma, Lipogenesis, Wnt Signaling Pathway
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