Cited by 551Tryptophan and brain disordersAmino Acid Enzymes and MetabolismReproductive System and Pregnancy

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Monitoring tryptophan metabolism in chronic immune activation

Schröcksnadel, Katharina, Wirleitner, Barbara, Winkler, Christiana, Fuchs, Dietmar·2006·Clinica Chimica Acta

DOI 10.1016/j.cca.2005.06.013

Open this paper in CoChat — free account

Abstract

The essential amino acid tryptophan is a constituent of proteins and is also a substrate for two important biosynthetic pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides. The latter pathway is initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). TDO is located in liver cells, whereas IDO is expressed in a variety of cells including monocyte-derived macrophages and dendritic cells and is preferentially induced by Th1-type cytokine interferon-gamma. Tryptophan depletion via IDO is part of the cytostatic and antiproliferative activity mediated by interferon-gamma in cells. In vivo tryptophan concentration can be measured by HPLC by monitoring its natural fluorescence (285 nm excitation and 365 nm emission wavelength). IDO activity is characterized best by the kynurenine to tryptophan ratio which correlates with concentrations of immune activation markers such as neopterin. Low serum/plasma tryptophan concentration is observed in infectious, autoimmune, and malignant diseases and disorders that involve cellular (Th1-type) immune activation as well as during pregnancy due to accelerated tryptophan conversion. Thus, in states of persistent immune activation, low tryptophan concentration may contribute to immunodeficiency. Decreased serum tryptophan can also effect serotonin biosyn…

Integrity signals

Registry

Crossref · 10.1016/j.cca.2005.06.013

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305
Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism
Taylor, M. W., & Feng, G. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907934 · Cited by 1,060
Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · cited 3×
“Tryptophan degradation by IDO was found to be necessary for induction of tolerance to the fetus [51].”
BackgroundInfluential

Flagged first, then by citations

Show all 0 references

Research works printed but not linked: 71

Yoshida, 1981, Induction of pulmonary indoleamine (2,3)-dioxygenase by interferon, Proc Natl Acad Sci U S A, 78, 129, 10.1073/pnas.78.1.129 · DOI
Werner, 1987, Human macrophages degrade tryptophan upon induction by interferon gamma, Life Sci, 41, 273, 10.1016/0024-3205(87)90149-4 · DOI
Hwu, 2000, Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation, J Immunol, 164, 3596, 10.4049/jimmunol.164.7.3596 · DOI
Byrne, 1986, Induction of tryptophan degradation in vitro and in vivo: a gamma interferon stimulated activity, J Interferon Res, 6, 389, 10.1089/jir.1986.6.389 · DOI
Werner-Felmayer, 1989, Characteristics of interferon induced tryptophan metabolism in human cells in vitro, Biochim Biophys Acta, 1012, 140, 10.1016/0167-4889(89)90087-6 · DOI
Weiss, 1999, Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells, Clin Exp Immunol, 116, 435, 10.1046/j.1365-2249.1999.00910.x · DOI
Werner, 1988, Tryptophan degradation in patients infected by human immunodeficiency virus, Biol Chem Hoppe-Seyler, 369, 337, 10.1515/bchm3.1988.369.1.337 · DOI
Fuchs, 1990, Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms, J Aquir Immune Defic Syndr, 3, 873
Wirleitner, 2003, Immune activation and degradation of tryptophan in coronary heart disease, Eur J Clin Invest, 33, 550, 10.1046/j.1365-2362.2003.01186.x · DOI
Denz, 1993, Weight loss in patients with hematological neoplasias is associated with immune system stimulation, Clin Investig, 71, 37, 10.1007/BF00210961 · DOI
Heyes, 1992, Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease, Brain, 115, 1249, 10.1093/brain/115.5.1249 · DOI
Widner, 1997, Simultaneous measurement of serum tryptophan and kynurenine by HPLC, Clin Chem, 43, 2424, 10.1093/clinchem/43.12.2424 · DOI
Wirleitner, 2003, Interferon-?-induced conversion of tryptophan: immunologic and neuropsychiatric aspects, Curr Med Chem, 10, 1581, 10.2174/0929867033457179 · DOI
Pfefferkorn, 1984, Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan, Proc Natl Acad Sci U S A, 81, 908, 10.1073/pnas.81.3.908 · DOI
de la Maza, 1988, Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media, Cancer Res, 48, 346
Ozaki, 1988, Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma, Proc Natl Acad Sci U S A, 85, 1242, 10.1073/pnas.85.4.1242 · DOI
Munn, 1999, Inhibition of T cell proliferation by macrophage tryptophan catabolism, J Exp Med, 189, 1363, 10.1084/jem.189.9.1363 · DOI
Munn, 2002, Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase, Science, 297, 1867, 10.1126/science.1073514 · DOI
Grohmann, 2003, Tolerance, DCs and tryptophan: much ado about IDO, Trends Immunol, 24, 242, 10.1016/S1471-4906(03)00072-3 · DOI
Terness, 2002, Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites, J Exp Med, 196, 447, 10.1084/jem.20020052 · DOI
Frumento, 2002, Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase, J Exp Med, 196, 459, 10.1084/jem.20020121 · DOI · Paper page
Fuchs, 1989, Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation, Immunol Lett, 23, 103, 10.1016/0165-2478(89)90120-X · DOI
Laich, 2002, More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC, Clin Chem, 48, 579, 10.1093/clinchem/48.3.579 · DOI
Steckel, 2005, Indoleamine 2,3-dioxygenase expression in monocytes of healthy nonpregnant women after induction with human choriongonadotropine, Scand J Immunol, 61, 213, 10.1111/j.0300-9475.2005.01538.x · DOI
Widner, 2000, Interferon-gamma-induced tryptophan degradation: neuropsychiatry and immunological consequences, Curr Drug Metabol, 1, 193, 10.2174/1389200003339063 · DOI
Fuchs, 1991, Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection, Immunol Lett, 28, 207, 10.1016/0165-2478(91)90005-U · DOI
Huengsberg, 1998, Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients, Clin Chem, 44, 858, 10.1093/clinchem/44.4.858 · DOI · Paper page
Look, 2000, Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease, AIDS Res Hum Retrovir, 16, 1215, 10.1089/08892220050116989 · DOI
Gisslén, 1994, Tryptophan concentrations increase in cerebrospinal fluid and blood after zidovudine treatment in patients with HIV type 1 infection, AIDS Res Hum Retrovir, 10, 947, 10.1089/aid.1994.10.947 · DOI
Zangerle, 2002, Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection, Clin Immunol, 104, 242, 10.1006/clim.2002.5231 · DOI
Pellegrin, 2005, Enhanced enzymatic degradation of tryptophan by indoleamine (2,3)-dioxygenase contributes to the tryptophan deficient state seen after major trauma, Shock, 23, 209
Murr, 2001, Neopterin production and tryptophan degradation in humans infected by Streptococcus pyogenes, Med Microbiol Immunol, 189, 161, 10.1007/s430-001-8023-3 · DOI
Fuchs, 1991, Kynurenine in cerebrospinal fluid of patients with Lyme neuroborreliosis, Immunol Infect Dis, 1, 271
Wolf, 2004, Overexpression of indoleamine 2,3-dioxygenase (IDO) in human inflammatory bowel disease, Clin Immunol, 113, 47, 10.1016/j.clim.2004.05.004 · DOI
Schroecksnadel, 2005, Tryptophan degradation in patients with gynecological cancer correlates with immune activation, Cancer Lett, 223, 323, 10.1016/j.canlet.2004.10.033 · DOI
Iwagaki, 1995, Decreased serum tryptophan in patients with cancer cachexia correlates with increased serum neopterin, Immunol Invest, 24, 467, 10.3109/08820139509066843 · DOI
Iwagaki, 1997, Cancer cachexia and depressive states: a neuro-endocrine-immunological disease?, Acta Med Okayama, 51, 233
Giusti, 1996, Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic pararesis and adult T-cell leukemia/lymphoma, Cancer Epidemiol Biomark Prev, 5, 699
Huang, 2002, Tryptophan decrease in advanced colorectal cancer correlates with immune activation and impaired quality of life, Br J Cancer, 86, 1691, 10.1038/sj.bjc.6600336 · DOI
Widner, 2000, Enhanced tryptophan degradation in systemic lupus erythematosus, Immunobiology, 201, 621, 10.1016/S0171-2985(00)80079-0 · DOI
Forrest, 2003, Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment, Adv Exp Med Biol, 527, 287, 10.1007/978-1-4615-0135-0_32 · DOI
Schroecksnadel, 2003, Increased degradation of tryptophan in blood of patients with rheumatoid arthritis, J Rheumatol, 30, 1935
Widner, 2000, Tryptophan degradation and immune activation in Alzheimer's disease, J Neural Trans, 107, 343, 10.1007/s007020050029 · DOI
Leblhuber, 1998, Activated immune system in patients with Huntington's disease, Clin Chem Lab Med, 36, 747, 10.1515/CCLM.1998.132 · DOI
Widner, 2002, Increased neopterin production and tryptophan degradation in advanced Parkinson's disease, J Neural Trans, 109, 181, 10.1007/s007020200014 · DOI
Frick, 2004, Increasing production of homocysteine and neopterin and degradation of tryptophan with older age, Clin Biochem, 37, 684, 10.1016/j.clinbiochem.2004.02.007 · DOI
Brown, 1986, Effects of interferon and interleukin-2 on tryptophan metabolism in humans, J Cell Biochem Suppl, 10C, 230
Wirleitner, 2002, Monocyte-derived dendritic cells release neopterin, J Leukoc Biol, 72, 1148, 10.1189/jlb.72.6.1148 · DOI
Schroecksnadel, 1996, Decreased plasma tryptophan in pregnancy, Obstet Gynecol, 88, 47, 10.1016/0029-7844(96)00084-1 · DOI
Schroecksnadel, 2003, Longitudinal study of tryptophan degradation during and after pregnancy, Life Sci, 72, 785, 10.1016/S0024-3205(02)02304-4 · DOI
Munn, 1998, Prevention of allogeneic fetal rejection by tryptophan catabolism, Science, 281, 1191, 10.1126/science.281.5380.1191 · DOI
Fuchs, 1989, Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection, Clin Chem, 35, 1746, 10.1093/clinchem/35.8.1746 · DOI
Fahey, 1990, The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1, N Engl J Med, 322, 166, 10.1056/NEJM199001183220305 · DOI
Fuchs, 1990, Increased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 production, Clin Exp Immunol, 80, 44, 10.1111/j.1365-2249.1990.tb06439.x · DOI
Fuchs, 1991, Immune activation and the anaemia associated with chronic inflammatory disorders, Eur J Haematol, 46, 65, 10.1111/j.1600-0609.1991.tb00524.x · DOI
Weiss, 2004, Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation, Eur J Haematol, 72, 130, 10.1046/j.0902-4441.2003.00197.x · DOI
Owens, 1994, Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter, Clin Chem, 40, 288, 10.1093/clinchem/40.2.288 · DOI
Murr, 2000, Immune reaction links disease progression in cancer patients with depression, Med Hypotheses, 55, 137, 10.1054/mehy.1999.1043 · DOI
Widner, 2002, Neopterin production tryptophan degradation and mental depression: what is the link?, Brain Behav Immun, 16, 590, 10.1016/S0889-1591(02)00006-5 · DOI
Launay, 1988, Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patients, J Acquir Immune Defic Syndr, 1, 324
Maes, 1994, Increased neopterin and interferon-gamma secretion and lower availability of l-tryptophan in major depression: further evidence for an immune response, Psych Res, 54, 143, 10.1016/0165-1781(94)90003-5 · DOI · Paper page
DeVane, 1998, Differential pharmacology of newer antidepressants, J Clin Psych, 59, 85
Suarez, 2001, Outcome of patients with HIV-1-related cognitive impairment on highly active antiretroviral therapy, AIDS, 15, 195, 10.1097/00002030-200101260-00008 · DOI
Gendelman, 1998, Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia, J Infect Dis, 178, 1000, 10.1086/515693 · DOI
Judd, 2000, Depressive symptoms reduced in individuals with HIV/AIDS treated with highly active antiretroviral therapy: a longitudinal study, Aust NZ J Psychiatry, 34, 1015, 10.1080/000486700278 · DOI
Murray, 2003, Tryptophan depletion and HIV infection: a metabolic link to pathogenesis, Lancet Infect Dis, 3, 644, 10.1016/S1473-3099(03)00773-4 · DOI
Cady, 1991, 1-Methyl-dl-tryptophan, beta-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase, Arch Biochem Biophys, 291, 326, 10.1016/0003-9861(91)90142-6 · DOI
Winkler, 2004, St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro, Biol Chem, 385, 1197, 10.1515/BC.2004.155 · DOI
Schroecksnadel, 2005, Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro, Clin Exp Immunol, 140, 41, 10.1111/j.1365-2249.2005.02746.x · DOI
Winkler, 2004, In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells, Planta Med, 70, 205, 10.1055/s-2004-815536 · DOI
Murr, 2005, Antioxidants may increase the probability of developing allergic diseases and asthma, Med Hypotheses, 64, 973, 10.1016/j.mehy.2004.11.011 · DOI

Sorted by citations

Items 201–300 of 503

L -kynurenine: metabolism and mechanism of neuroprotection
Robotka, H., Toldi, J., & Vécsei, L. (2008) · Future Neurology · doi:10.2217/14796708.3.2.169 · Cited by 36
“The ratio of the concentrations of L-KYN and TRP is an appropriate indicator of TRP degradation [16].”
Background
NAD+ Metabolism, Metabolic Stress, and Infection
Groth, B., Venkatakrishnan, P., & Lin, S.-J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.686412 · Cited by 42
Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain
Pires, A. S., Heng, B., Tan, V. X., Latini, A., Russo, M. A., Santarelli, D. M., Bailey, D., Wynne, K., O'Brien, J. A., Guillemin, G. J., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00890 · Cited by 37
“…also been shown to sensitize peripheral nociceptors indirectly through the activation of macrophages, and cause sprouting of sensory nerve endings Frontiers in Neuroscience | www.frontiersin.org 6 August 2020 | Volume 14 | Article 890 in the skin (Schweizerhof et al., 2009; Tewari et al., 2020).”
Background
Decline of exhaled isoprene in lung cancer patients correlates with immune activation
Fuchs, D., Jamnig, H., Heininger, P., Klieber, M., Schroecksnadel, S., Fiegl, M., Hackl, M., Denz, H., & Amann, A. (2012) · Journal of Breath Research · doi:10.1088/1752-7155/6/2/027101 · Cited by 34
Self-citation
Association between increased tryptophan degradation and depression in cancer patients
Kurz, K., Schroecksnadel, S., Weiss, G., & Fuchs, D. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328340d849 · Cited by 33
Self-citation
LPS-induced NF-kappaB expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2,3-dioxygenase.
Schroecksnadel, S., Jenny, M., Kurz, K., Klein, A., Ledochowski, M., Uberall, F., & Fuchs, D. (2010) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2010.07.134 · Cited by 34
Self-citation
Inhibition of indoleamine 2, 3‐dioxygenase‐mediated tryptophan catabolism accelerates crescentic glomerulonephritis
Hou, W.-P., Li, S.-Z., Wu, Y.-P., Du, X., & Yuan, F.-H. (2009) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2009.03902.x · Cited by 34
Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19
Maeda, R., Seki, N., Uwamino, Y., Wakui, M., Nakagama, Y., Kido, Y., Sasai, M., Taira, S., Toriu, N., Yamamoto, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44266-z · Cited by 40
“Although a directcausalrelationshipremainsspeculative,theincreasedmetabolic reactivity observed in the lung parenchyma of male participants, particularly increased amino acid catabolism,maythereforecontribute to the increased male mortality associated with COVID-19 50 .”
Influential
Identification of biomarkers for unstable angina by plasma metabolomic profiling
Sun, M., Gao, X., Zhang, D., Ke, C., Hou, Y., Fan, L., Zhang, R., Liu, H., Li, K., & Yu, B. (2013) · Molecular BioSystems · doi:10.1039/c3mb70216b · Cited by 34
Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response
Wikoff, W., Kalisak, E., Trauger, S., Manchester, M., & Siuzdak, G. (2009) · Journal of Proteome Research · doi:10.1021/pr900275p · Cited by 33
Plasma tryptophan and kynurenine in females with temporomandibular disorders and fibromyalgia - An exploratory pilot study.
Barjandi, G., Jounger, S. L., Löfgren, M., Bileviciute-Ljungar, I., Kosek, E., & Ernberg, M. (2020) · Journal of Oral Rehabilitation · doi:10.1111/joor.12892 · Cited by 32
Indoleamine 2,3‐dioxygenase 1 in coronary atherosclerotic plaque enhances tissue factor expression in activated macrophages
Watanabe, Y., Koyama, S., Yamashita, A., Matsuura, Y., Nishihira, K., Kitamura, K., & Asada, Y. (2018) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12128 · Cited by 32
A validated liquid chromatography‐high resolution‐tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma
Arnhard, K., Pitterl, F., Sperner-Unterweger, B., Fuchs, D., Koal, T., & Oberacher, H. (2018) · Electrophoresis · doi:10.1002/elps.201700400 · Cited by 32
Self-citation
Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice
van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1hi0216-062rr · Cited by 36
“It is also increased in several autoimmune and neurodegenerative diseases [14, 15].”
Background
Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes
Yokoi, N., Beppu, M., Yoshida, E., Hoshikawa, R., Hidaka, S., Matsubara, T., Shinohara, M., Irino, Y., Hatano, N., & Seino, S. (2015) · Metabolomics · doi:10.1007/s11306-015-0784-9 · Cited by 34
“In contrast, IDO is expressed ubiquitously, and the expression is induced by pro-inflammatory cytokines (Oxenkrug 2010; Schrocksnadel et al. 2006).”
Background
Differential expression and regulation of Tdo2 during mouse decidualization
Li, D., Gao, Y., Tian, X., Yang, Z., Cao, H., Zhang, Q., Guo, B., & Yue, Z. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0429 · Cited by 30
“In mammals, most of tryptophan was metabolized along the kynurenine pathway and tryptophan metabolism was closely correlated with pregnancy (Stone & Darlington 2002, Schröcksnadel et al. 2006).”
Background
Serotonin 5- Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases
Nichols, C. D. (2009) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2009/475108 · Cited by 43
Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders
Mitra, S., Banik, A., Saurabh, S., Maulik, M., & Khatri, S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0998-21.2022 · Cited by 45
“This shift from OXPHOS to glycolysis in microglia is because of upregulation of GLUT1, which is concomitant with increased synthesis of hexokinase and PFKFB3 (the rate-limiting enzymes of the glycolytic pathway) and activation of mammalian target of rapamycin (mTOR), which regulates transcriptional control of glycolys…”
Influential
Indoleamine 2,3-dioxygenase expression and overall survival in patients diagnosed with breast cancer in Pakistan
Asghar, K., Loya, A., Rana, I. A., Tahseen, M., Ishaq, M., Farooq, A., Bakar, M. A., & Masood, I. (2019) · Cancer Management and Research · doi:10.2147/cmar.s184221 · Cited by 31
“IDO emerged from tumor has capability to obstruct the antitumor immune responses and promote metastasis.(9,10) Several researchers identified the IDO expression in breast, colorectal, ovarian, and endometrial cancers.”
Background
Immune biomarkers in older adults: Role of physical activity
Valdiglesias, V., Sánchez-Flores, M., Maseda, A., Lorenzo‐López, L., Marcos-Pérez, D., Facal, A. L.-C., Strasser, B., Fuchs, D., Laffón, B., Millán-Calentí, J. C., et al. (2017) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2017.1286898 · Cited by 51
“This phenomenon acts as a potent antimicrobial and antitumor mechanism and limits intracellular pathogen or tumor cell growth since it reduces the amount of tryptophan available for protein synthesis (Schröcksnadel et al., 2006).”
BackgroundSelf-citation
HORSE SPECIES SYMPOSIUM: Canine intestinal microbiology and metagenomics: From phylogeny to function1
Guard, B. C., & Suchodolski, J. S. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-0029 · Cited by 36
IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype
Lee, A., Kanuri, N. D., Zhang, Y., Sayuk, G. S., Li, E., & Ciorba, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115848 · Cited by 35
“[18] We have previously shown that IDO1 expression is increased in active Crohn’s disease and that Crohn’s disease activity correlates with the serum K/T ratio.”
Background
Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure
Laffón, B., Aguilera, F., Ríos-Vázquez, J., García-Léston, J., Fuchs, D., Valdiglesias, V., & Pásaro, E. (2013) · Environment International · doi:10.1016/j.envint.2013.05.014 · Cited by 30
“Furthermore, a strong association has been described between neopterin concentration and the rate of tryptophan degradation (Kyn/ Trp ratio) (Schröcksnadel et al., 2006).”
BackgroundSelf-citation
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens
Mailankot, M., Staniszewska, M., Butler, H., Caprara, M., Howell, S., Wang, B.-L., Doller, C. M., Reneker, L., & Nagaraj, R. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.22 · Cited by 31
“19 Tryptophan degradation increases in rheumatoid arthriti”
Background
Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells.
Jenny, M., Santer, E., Klein, A., Ledochowski, M., Schennach, H., Ueberall, F., & Fuchs, D. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.01.011 · Cited by 31
Self-citation
Associations between tryptophan and iron metabolism observed in individuals with and without iron deficiency
Wenninger, J., Meinitzer, A., Holasek, S., Schnedl, W., Zelzer, S., Mangge, H., Herrmann, M., & Enko, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-51215-8 · Cited by 30
Changes in brain kynurenine levels via gut microbiota and gut‐barrier disruption induced by chronic ethanol exposure in mice
Giménez‐Gómez, P., Pérez‐Hernández, M., O’Shea, E., Caso, J. R., Martín‐Hernández, D., Alou, L., Gómez-Lus, M. L., Gutiérrez‐López, M. D., & Colado, M. I. (2019) · The FASEB Journal · doi:10.1096/fj.201900491rr · Cited by 34
“Both enzymes show low basal activity in the brain, but IDO is under proinflammatory regulation (43, 97, 98) and can be substantially increased following stimulation and thus play a relevant role in brain (99).”
Background
Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment
Jrad-Lamine, A., Henry-Berger, J., Damon‐Soubeyrand, C., Saez, F., Kocer, A., Janny, L., Pons‐Rejraji, H., Munn, D. H., Mellor, A. L., Gharbi, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066494 · Cited by 35
“The KYN:TRP ratio (KTR) is commonly used as an indicator of the activation of the KYN pathway [15].”
Method
Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene
Soichot, M., Hennart, B., Saabi, A. A., Leloire, A., Froguel, P., Lévy‐Marchal, C., Poulain‐Godefroy, O., & Allorge, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025470 · Cited by 28
“activity [18], it appears that IDO activity exhibits relatively large”
Background
Crinum Latifolium Leave Extracts Suppress Immune Activation Cascades in Peripheral Blood Mononuclear Cells and Proliferation of Prostate Tumor Cells
Jenny, M., Wondrak, A., Zvetkova, E., Nguyen, T. N. P., Phi, P. P., Schennach, H., Culig, Z., Ueberall, F., & Fuchs, D. (2011) · Scientia Pharmaceutica · doi:10.3797/scipharm.1011-13 · Cited by 30
“2011; 79: 323–335 tryptophan degradation and neopterin production develop in patients during diseases which are associated with Th1-type immune activation such as infections, autoimmune diseases, malignant disorders, and during allograft rejection episodes [11, 17, 18].”
BackgroundSelf-citation
Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children.
Strand, T., Taneja, S., Bhandari, N., Refsum, H., Ueland, P., Gjessing, H., Bahl, R., Schneede, J., Bhan, M., & Sommerfelt, H. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.139 · Cited by 30
“Notably, tHcy increases with activation of the immune system, particularly the TH1 response (23, 24).”
Background
Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFκB p65 pathway
Shi, T., Shi, Y., Gao, H., Ma, Y., Wang, Q., Shen, S., Shao, X., Gong, W., Chen, X., Qin, J., et al. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.03.003 · Cited by 29
Altered Metabolomic Profile in Patients with Peripheral Artery Disease
Ismaeel, A., Franco, M. E., Lavado, R., Papoutsi, E., Casale, G. P., Fuglestad, M. A., Mietus, C. J., Haynatzki, G. R., SMITH, R. S., Bohannon, W. T., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091463 · Cited by 35
“Specifically, reduced tryptophan may be due to accelerated conversion to kynurenine by indoleamine 2,3-dioxygenase (IDO1), which is activated by cytokines, such as tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) (Figure 3) [52].”
Background
Modulatory effects of acupuncture on murine depression-like behavior following chronic systemic inflammation
Kwon, S., Lee, B., Yeom, M., Sur, B., Kim, M., Kim, S.-T., Park, H., Lee, H., & Hahm, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.07.009 · Cited by 29
Clinical relevance of indoleamine 2,3-dioxygenase for alloimmunity and transplantation
Brandacher, G., Margreiter, R., & Fuchs, D. (2008) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3282f3df26 · Cited by 28
Self-citation
Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis
Cavaleri, D., Bartoli, F., Capogrosso, C. A., Guzzi, P., Moretti, F., Riboldi, I., Misiak, B., Kishi, T., Rubín, R. T., Fuchs, D., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110633 · Cited by 32
Self-citation
The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment
Park, J. K., Lee, K. J., Kim, J. Y., & Kim, H. (2021) · Psychiatry Investigation · doi:10.30773/pi.2020.0205 · Cited by 36
A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Qi, Y., Pi, Z., Liu, S., Song, F.-R., Lin, N., & Liu, Z.-Q. (2014) · Molecular Biosystems · doi:10.1039/c4mb00131a · Cited by 28
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone
Wolowczuk, I., Hennart, B., Leloire, A., Bessede, A., Soichot, M., Taront, S., Caiazzo, R. J., Raverdy, V., Pigeyre, M., Guillemin, G. J., et al. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00373.2011 · Cited by 123
“It was postulated that kynurenine/tryptophan ratio disequilibrium concomitant with immune system activation is the hallmark of IDO1 rather than TDO2 activation (36).”
Background
Nutritional Tryptophan Restriction and the Role of Serotonin in Development and Plasticity of Central Visual Connections
Serfaty, C. A., Oliveira-Silva, P., Faria‐Melibeu, A. D. C., & Campello‐Costa, P. (2008) · NeuroImmunoModulation · doi:10.1159/000153421 · Cited by 28
Neuroendocrine tumours and their microenvironment
de Hosson, L. D., Takkenkamp, T. J., Kats‐Ugurlu, G., Bouma, G., Bulthuis, M. L. C., de Vries, E. G. E., van Faassen, M. H. J. R., Kema, I. P., & Walenkamp, A. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02556-1 · Cited by 27
Influence of different rehabilitative aerobic exercise programs on (anti-) inflammatory immune signalling, cognitive and functional capacity in persons with MS – study protocol of a randomized controlled trial
Joisten, N., Rademacher, A., Bloch, W., Schenk, A., Oberste, M., Dalgas, U., Langdon, D. W., Caminada, D., Purde, M.-T., Gonzenbach, R. R., et al. (2019) · BMC Neurology · doi:10.1186/s12883-019-1267-9 · Cited by 24
“KYN itself has previously been described to stimulate the differentiation of Tregs and to inhibit the activation of pro-inflammatory immune cells [23, 24].”
Background
Coffee Extracts Suppress Tryptophan Breakdown in Mitogen-Stimulated Peripheral Blood Mononuclear Cells
Gostner, J. M., Schroecksnadel, S., Jenny, M., Klein, A., Ueberall, F., Schennach, H., & Fuchs, D. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2014.907756 · Cited by 27
“Neopterin concentrations correlate closely with increased IDO activity in various human diseases and in, for example, patients with HIV infection, malignancy and autoimmune syndromes, elevated Kyn/Trp and neopterin levels usually parallel the clinical course and are predictive for unfavorable outcomes [30].”
BackgroundSelf-citation
Simultaneous analysis of kynurenine and tryptophan in human plasma by capillary electrophoresis with UV detection.
Zinellu, A., Sotgia, S., Deiana, L., Talanas, G., Terrosu, P., & Carru, C. (2012) · Journal of Separation Science · doi:10.1002/jssc.201200021 · Cited by 27
IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression
Ohmatsu, H., Humme, D., Gonzalez, J., Gulati, N., Möbs, M., Sterry, W., & Krueger, J. G. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1181237 · Cited by 32
Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts.
Hautz, T., Brandacher, G., Zelger, B., Müller, H., Lee, A., Fuchs, D., Margreiter, R., & Schneeberger, S. (2009) · Transplantation Proceedings · doi:10.1016/j.transproceed.2009.01.008 · Cited by 26
Self-citation
Tryptophan Metabolism in Bipolar Disorder in a Longitudinal Setting
Fellendorf, F. T., Gostner, J. M., Lenger, M., Platzer, M., Birner, A., Maget, A., Queissner, R., Tmava‐Berisha, A., Pater, C. A., Ratzenhofer, M., et al. (2021) · Antioxidants · doi:10.3390/antiox10111795 · Cited by 29
“Elevated kynurenine to tryptophan ratio in relation to increased neopterin can be found frequently in conditions where the immune system is chronically activated, including infections, malignancies, cardiovascular and neurodegenerative disorders [37].”
BackgroundSelf-citation
Impact of Exercise on Immunometabolism in Multiple Sclerosis
Afzal, R., Dowling, J. K., & McCoy, C. E. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9093038 · Cited by 29
Urinary metabolomics study on the anti-inflammation effects of flavonoids obtained from Glycyrrhiza
Wei, M., Ma, Y., Liu, Y., Zhou, Y., Men, L., Yue, K., Pi, Z., Liu, Z., & Liu, Z. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.04.007 · Cited by 32
The Relationship of Alcohol Use Disorders and Depressive Symptoms to Tryptophan Metabolism: Cross-Sectional Data from a Nepalese Alcohol Treatment Sample
Neupane, S. P., Lien, L., Martínez, P., Hestad, K. A., & Bramness, J. G. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12651 · Cited by 25
“The serum kynurenine to tryptophan ratio (KT ratio) reliably reflects IDO activity, which is subject to activation by inflammatory cytokines (Raison et al., 2010; Schrocksnadel et al., 2006).”
A reagentless enantioselective sensor for tryptophan enantiomers via nanohybrid matrices
Zhang, Q., Guo, L., Huang, Y.-H., Wang, Y., Han, Q., & Fu, Y. (2013) · doi:10.1039/c3ay40236c · Cited by 25
Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase
Kuehnl, S., Schroecksnadel, S., Temml, V., Gostner, J., Schennach, H., Schuster, D., Schwaiger, S., Rollinger, J., Fuchs, D., & Stuppner, H. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.06.006 · Cited by 25
“, in cancer patients during treatment with IFNs (Byrne et al. 1986; Schroecksnadel et al. 2006).”
BackgroundSelf-citation
Tryptophan degradation and serum neopterin concentrations in intensive care unit patients
Girgin, G., Şahin, T. T., Fuchs, D., Yüksel, O., Kurukahvecioğlu, O., Şare, M., & Baydar, T. (2011) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2010.545960 · Cited by 27
“Furthermore, changes in IDO activity can be used as a marker of modulation in cellular immunity (Taylor and Feng, 1991; Widner et al., 2000; Schroecksnadel et al., 2006; King and Thomas, 2007; Munn and Mellor, 2007).”
BackgroundSelf-citation
Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis
Atlas, A., Franzen-Röhl, E., Söderlund, J., Jönsson, E. G., Samuelsson, M., Schwieler, L., Sköldenberg, B., & Engberg, G. (2013) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s13256 · Cited by 25
Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders
Kondo, T., Okada, Y., Saika, S., Yamaguchi, N., Hatakeyama, S., & Maruyama, K. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151418 · Cited by 24
Alterations and correlations of gut microbiota, fecal, and serum metabolome characteristics in a rat model of alcohol use disorder
Wang, X., Li, L., Bian, C., Bai, M., Yu, H., Gao, H., Zhao, J., Zhang, C., & Zhao, R. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1068825 · Cited by 28
“Most tryptophan is degraded through the kynurenine pathway metabolism in mammals, and previous studies found that the modulation of the kynurenine pathway is associated with gut microbiota changes, peripheral inflammation, and psychological symptoms in the AUD (Schröcksnadel et al., 2006; Vécsei et al., 2013; Leclercq…”
Background
Circadian movement behaviours and metabolism differences of the Pacific abalone Haliotis discus hannai.
Gao, X.-L., Luo, X., You, W., & Ke, C.-H. (2020) · Journal of Photochemistry and Photobiology. B: Biology · doi:10.1016/j.jphotobiol.2020.111994 · Cited by 24
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease
Karlsson, T., Strand, E., Dierkes, J., Drevon, C., Øyen, J., Midttun, Ø., Ueland, P., Gudbrandsen, O., Pedersen, E., & Nygård, O. (2017) · European Journal of Nutrition · doi:10.1007/s00394-015-1077-9 · Cited by 24
Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC
Gostner, J. M., Ganzera, M., Becker, K., Geisler, S., Schroecksnadel, S., Überall, F., Schennach, H., & Fuchs, D. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-503 · Cited by 30
“and depressive symptoms especially in long-lasting and chronic diseases [28].”
BackgroundSelf-citation
Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)‐dioxygenase activity in human PBMC
Gostner, J. M., Schroecksnadel, S., Becker, K., Jenny, M., Schennach, H., Überall, F., & Fuchs, D. (2012) · FEBS Open Bio · doi:10.1016/j.fob.2012.08.004 · Cited by 24
“All rights reserved.”
Self-citation
Tryptophan Metabolism: Implications for Biological Processes, Health and Disease
Engin, A., & Engin, A. (2015) · Molecular and Integrative Toxicology · doi:10.1007/978-3-319-15630-9 · Cited by 24
“As stated above IDO activity is characterized best by the Kyn to Trp ratio, but considering the immune tolerance, it should be correlated with the concentration of immune activation marker such as neopterin (Schröcksnadel et al. 2006 ).”
Background
Longitudinal characterization of the metabolome of dairy cows transitioning from one lactation to the next: Investigations in blood serum
Ghaffari, M. H., Daniel, J., Sadri, H., Schuchardt, S., Martín‐Tereso, J., & Sauerwein, H. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23841 · Cited by 24
“The ratio of kynurenine to Trp in serum, an indicator of indoleamine 2,3-dioxygenase activity and inflammation (Schröcksnadel et al., 2006), did not change significantly over time, unlike kynurenine and Trp alone in this study.”
Background
Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice
Cuny, H., Bozon, K., Kirk, R. B., Sheng, D. Z., Bröer, S., & Dunwoodie, S. L. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049647 · Cited by 27
The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites
Aarsland, T. I. M., Leskauskaite, I., Midttun, Ø., Ueland, P. M., Ulvik, A., Oltedal, L., Oedegaard, K. J., Haavik, J., & Keßler, U. (2017) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(17)31192-6 · Cited by 4
“The kynurenine to tryptophan ratio (KTR) functions as a proxy measure of INF-g mediated activation of cellular immunity and this ratio has been shown to correlate positively with the concentration of other immune markers, like neopterin an established marker of cellular immune activation [9].”
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
Engin, A., Gonul, I., Engin, A., Karamercan, A., Sepici-Dinçel, A., & Dursun, A. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i13.3592 · Cited by 23
Controversies about a common etiology for eating and mood disorders
Rossetti, C., Halfon, O., & Boutrel, B. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01205 · Cited by 25
Urine soluble urokinase-type plasminogen activator receptor levels correlate with proteinuria in Puumala hantavirus infection
Outinen, T., Mäkelä, S., Huttunen, R., Mäenpää, N., Libraty, D., Vaheri, A., Mustonen, J., & Aittoniemi, J. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12257 · Cited by 23
Tryptophan Metabolism in Post-Withdrawal Alcohol-Dependent Patients
von Gleissenthall, G., Geisler, S., Malík, P., Kemmler, G., Benicke, H., Fuchs, D., & Mechtcheriakov, S. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu011 · Cited by 23
Self-citation
Ambivalent effects of dendritic cells displaying prostaglandin E 2‐induced indoleamine 2,3‐dioxygenase
Lanzinger, M., Jürgens, B., Hainz, U., Dillinger, B., Raberger, J., Fuchs, D., & Heitger, A. (2012) · European Journal of Immunology · doi:10.1002/eji.201141765 · Cited by 23
Self-citation
Is Indoleamine 2,3-Dioxygenase Important for Graft Acceptance in Highly Sensitized Patients After Combined Auxiliary Liver-Kidney Transplantation?
Ingelsten, M., Gustafsson, K., Oltean, M., Karlsson-Parra, A., Olausson, M., Haraldsson, B., & Nystrom, J. (2009) · Transplantation · doi:10.1097/tp.0b013e3181b72e49 · Cited by 23
Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery
Geisler, S., Lytton, S. D., Toàn, N. L., Nghia, T. H., Nam, N. M., Hung, H. V., Sơn, N. T., Anh, Đ. T., Tuyen, H. T., Tien, T. V., et al. (2019) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2019.12.005 · Cited by 25
Self-citation
Study of disulfide reduction and alkyl chloroformate derivatization of plasma sulfur amino acids using gas chromatography–mass spectrometry
Švagera, Z., Hanzlíková, D., Šimek, P., & Hušek, P. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-5727-y · Cited by 22
Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice
Miura, H., Shirokawa, T., Isobe, K., & Ozaki, N. (2008) · Stress · doi:10.1080/10253890802252442 · Cited by 25
“The ratio of KYN/TRP, i.e., the ratio of the concentration of the first product of IDO to the concentration of the substrate of IDO is known to be an appropriate indicator of TRP degradation (Schrocksnadel et al. 2006).”
Background
Animal models to study the impact of nutrition on the immune system of the transition cow
Dänicke, S., Meyer, U., Kersten, S., & Frahm, J. (2018) · Research in Veterinary Science · doi:10.1016/j.rvsc.2018.01.023 · Cited by 30
The tryptophan/kynurenine pathway, systemic inflammation, and long-term outcome after kidney transplantation.
de Vries, L. D., Minović, I., Franssen, C., van Faassen, M., Sanders, J., Berger, S., Navis, G., Kema, I., & Bakker, S. (2017) · AJP - Renal Physiology · doi:10.1152/ajprenal.00690.2016 · Cited by 21
“6 Living donor, n (%) 80 (14) Acute rejection, n (%) 256 (46) Previous dialysis duration (mo) 27 [13-48] 0 398 HLA mismatches (n) 1.”
Neopterin Release and Tryptophan Degradation in Patients with Uveitis
Palabıyık, Ş. S., Keleş, S., Girgin, G., Arpalı, E., Topdagi, E., & Baydar, T. (2016) · Current Eye Research · doi:10.3109/02713683.2015.1133830 · Cited by 18
“Besides this, determining Trp and Kyn concentrations and the ratio of Kyn to Trp (Kyn/Trp) are considered to be helpful in clarifying the relationship between immune activation in chronic diseases and Trp degradation.(6,7) IDO activity is induced by Th1-type cytokine IFN-γ in parallel to neopterin production in human…”
Background
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM).
Blankfield, A. (2012) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s10085 · Cited by 23
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study
Kurgan, Ş., Önder, C., Balcı, N., Akdoğan, N., ALTINGÖZ, S. M., Serdar, M. A., & Günhan, M. (2022) · Clinical Oral Investigations · doi:10.1007/s00784-022-04528-4 · Cited by 28
A preliminary study on the detection of potential contaminants in the European brown hare (Lepus europaeus) by suspect and microplastics screening
Hornek-Gausterer, R., Oberacher, H., Reinstadler, V., Hartmann, C., Liebmann, B., Lomako, I., Scharf, S., Posautz, A., & Kübber-Heiss, A. (2021) · Environmental Advances · doi:10.1016/j.envadv.2021.100045 · Cited by 20
The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites
Yeung, K. T. D., Penney, N. C., Whiley, L., Ashrafian, H., Lewis, M. R., Purkayastha, S., Darzi, A. W., & Holmes, E. C. (2022) · Scientific Reports · doi:10.1038/s41598-021-03833-4 · Cited by 23
“Insulin, n (%) 2 (20) 1 (10) 0 (0) 0 (0)”
Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules
D’Arrigo, P., Tufano, M., Rea, A., Vigorito, V., Novizio, N., Russo, S., Romano, M. F., & Romano, S. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666181106114421 · Cited by 21
Monoaminergic and Kynurenergic Characterization of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Cerebrospinal Fluid and Serum
Janssens, J., Vermeiren, Y., van Faassen, M. H. J. R., van der Ley, C., Kema, I. P., & Deyn, P. P. D. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03002-5 · Cited by 22
Ω-3 fatty acids-supplementary in gestation alleviates neuroinflammation and modulates neurochemistry in rats
Tang, M., Dang, R., Liu, S., Zhang, M., Zheng, Y., Yang, R., & Yin, T. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0894-2 · Cited by 16
Application of pathways activity profiling to urine metabolomics for screening Qi-tonifying biomarkers and metabolic pathways of honey-processed Astragalus.
Liu, W., Li, C.-Y., Huang, J., Liao, J., Liao, S.-Y., Ma, W., Chen, H., & Rui, W. (2018) · Journal of Separation Science · doi:10.1002/jssc.201701371 · Cited by 20
Potential acute effects of suspended aluminum nitride (AlN) nanoparticles on soluble microbial products (SMP) of activated sludge.
Zhou, L.-J., Zhuang, W.-Q., Wang, X., Yu, K., Yang, S.-F., & Xia, S.-Q. (2017) · Journal of Environmental Science · doi:10.1016/j.jes.2017.02.001 · Cited by 20
“…nitride nanoparticles Topic: Soluble microbial products (SMP) Activated sludge Bacterial viability Introduction A variety of engineered nanoparticles (NPs) is now widely used in commodities, pharmaceutics, cosmetics, biomedical products, and industries (Lee et al., 2015; Shaalan et al., 2016).”
Background
A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
Zhao, L., Wan, L., Qiu, X., Li, R.-M., Liu, S.-M., & Wang, D. (2014) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2014/385102 · Cited by 20
“However, permanent state of immune activation and low level of tryptophan may contribute to development of immunodeficiency [30].”
Background
Analysis of tryptophan catabolism in HBV patients by HPLC with programmed wavelength ultraviolet detection.
Ma, L., Xu, B., Wang, W.-J., Deng, W., & Ding, M. (2009) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2009.04.009 · Cited by 20
Biochemical alterations in the follicular fluid of bovine peri-ovulatory follicles and their association with final oocyte maturation
Alrabiah, N. A., Simintiras, C. A., Evans, A. C. O., Lonergan, P., & Fair, T. (2022) · Reproduction and Fertility · doi:10.1530/raf-22-0090 · Cited by 14
Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors
Li, H., Liu, T., Heinsberg, L. W., Lockwood, M. B., Wainwright, D., Jang, M., & Doorenbos, A. (2020) · Biological Research for Nursing · doi:10.1177/1099800420938141 · Cited by 19
“TDO is highly and constitutively expressed in the liver, but it is also present in the brain and induced or upregulated by endogenous and exogenous glucocorticoid(-like) molecules including cortisol and dexamethasone (Schröcksnadel et al., 2006).”
Background
Simultaneous determination of three potential cancer biomarkers in rat urine by synchronous fluorescence spectroscopy
Huang, L., Guo, L., Wan, Y., Pan, P., & Feng, L. (2013) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2013.12.001 · Cited by 20
Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells
Marttila, S., Jylhävä, J., Eklund, C., Hervonen, A., Jylhä, M., & Hurme, M. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-9 · Cited by 19
“Increased degradation of trp has been associated with elevated levels of inflammation markers, such as neopterin and IFN-ɣ, in HIV infection, sepsis, autoimmune disorders and malignancies [3].”
The pathophysiology and management of depression in cardiac surgery patients
Vu, T., & Smith, J. A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1195028 · Cited by 19
Relationships between body temperatures and inflammation indicators under physiological and pathophysiological conditions in pigs exposed to systemic lipopolysaccharide and dietary deoxynivalenol
Tesch, T., Bannert, E., Kluess, J., Frahm, J., Hüther, L., Kersten, S., Breves, G., Renner, L., Kahlert, S., Rothkötter, H., et al. (2018) · Journal of animal physiology and animal nutrition · doi:10.1111/jpn.12684 · Cited by 18
Resveratrol intake enhances indoleamine-2,3-dioxygenase activity in humans
Gualdoni, G. A., Fuchs, D., Zlabinger, G., & Gostner, J. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.06.008 · Cited by 18
“During infection, nutrient deprivation due to IDO activity decreases microbial growth and, in turn, also inhibits T-cell proliferation and activation [8].”
Self-citation
The application of L-tryptophan functionalized graphene-supported platinum nanoparticles for chiral recognition of DOPA enantiomers
Chen, Y., Xu, J.-J., Chen, C., Guo, D.-M., & Fu, Y. (2015) · doi:10.1039/c5nj00303b · Cited by 18
The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression
O'Connor, M., & Green, W. (2013) · Virology Journal · doi:10.1186/1743-422x-10-154 · Cited by 18
“Increased IDO expression occurs during human immunodeficiency virus (HIV) [26-29], simian immunodeficiency virus (SIV) [13,30] and murine LP-BM5 immunodeficiency-causing retroviral infections [31], yet a comprehensive understanding of the effect of IDO on these retroviral infections has not been provided.”
Background
Kynurenine/Tryptophan Ratio Predicts Angiotensin Receptor Blocker Responsiveness in Patients with Diabetic Kidney Disease
Wu, M., Lin, C., Chiu, D., & Chen, S. (2020) · Diagnostics · doi:10.3390/diagnostics10040207 · Cited by 21
“, KTR, is frequently utilized to evaluate the activity of the extrahepatic Trp degrading enzyme, IDO [29].”
Background
Metabolomics analysis of urine from rats administered with long-term, low-dose acrylamide by ultra-performance liquid chromatography-mass spectrometry
Shi, H., Hu, L., Chen, D., Bao, W., Yang, S. C., Zhao, X., & Sun, C. (2016) · Xenobiotica · doi:10.1080/00498254.2016.1196509 · Cited by 19
“This versatility results in different end-products, such as protein, serotonin, and kynurenines, followed by conversion to quinolinic acid, kynurenic acid, and so on (Ruddick et al., 2006, Schrocksnadel et al., 2006).”
Background
Antioxidants in Health and Disease
Zampelas, A., & Micha, R. (2015) · doi:10.1201/b18539 · Cited by 17
“The Th1-type immune response is involved in the pathogenesis of several inflammatory disorders like autoimmune syndromes, cardiovascular diseases, malignant tumor diseases, or neurodegenerative disorders (Romagnani, 2004; Schroecksnadel et al., 2006, 2007).”
Background
A Rheumatoid arthritis study using Raman spectroscopy
Carvalho, C., Martín, A. A., Santo, A., Andrade, L. E., Pinheiro, M., Cardoso, M. A., & Raniero, L. (2011) · doi:10.1007/s00214-011-0905-0 · Cited by 17
“In vivo, enhanced cytokine-induced degradation of tryptophan is observed whenever a cellular immune response is induced [ 64 ].”
Background

Authors: Schröcksnadel, K., Wirleitner, B., Winkler, C., & Fuchs, D.
Affiliations: Innsbruck Medical University (AT)
Corresponding author: Fuchs, Dietmar
ORCID: Wirleitner, Barbara
Fuchs, Dietmar
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2006-02
Volume: 364
Issue: 1-2
Pages: 82-90
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/j.cca.2005.06.013
OpenAlex: W2042985653
Cited by: 551
References: 0
Citations by year: 2026: 7 · 2025: 25 · 2024: 19 · 2023: 24 · 2022: 32 · 2021: 47 · 2020: 31 · 2019: 21 · 2018: 27 · 2017: 34 · 2016: 26 · 2015: 32 · 2014: 24 · 2013: 38 · 2012: 36
FWCI: 0.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: tryptophan metabolism, tryptophan depletion, indoleamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, kynurenine pathway, serotonin synthesis, interferon-gamma, chronic immune activation, Th1 response, neopterin, immunodeficiency, anemia, mood disorders, autoimmune disease, infectious diseases, pregnancy
MeSH terms: Autoimmune Diseases, Humans, Infections, Kynurenine, Neoplasms, Serotonin, Tryptophan, Tryptophan Hydroxylase, Tryptophan Oxygenase, Indoleamine-Pyrrole 2,3,-Dioxygenase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Monitoring tryptophan metabolism in chronic immune activation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks