The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Serum CA125 and NSE: Biomarkers of disease severity in patients with silicosis
Abstract
Background We investigated the clinical significance of tumor markers in patients with silicosis.Methods Eighty silicosis patients without malignancy and 50 healthy volunteers were compared for serum tumor marker concentrations. Pulmonary function and several routine laboratory tests were performed. Correlation between serum tumor marker concentrations and severity markers for silicosis was analyzed. Tumor marker concentrations were detected in both blood and BALF samples in silicosis patients. The pre- and post-lavage differences in the serum tumor marker concentrations were also investigated. Immunohistochemical staining for tumor markers was performed in a lung biopsy specimen from a silicosis patient.Results Both serum NSE and CA125 concentrations were significantly higher in cases compared with controls. Significant positive correlations were found between values of NSE and CA125 and LDH concentration. Significant negative correlations were also observed between values of NSE and CA125 and spirometric parameters. Patients with silicosis had higher concentrations of NSE in BALF than that in serum. 11 of 14 patients experienced a decrease in NSE concentrations following whole lung lavage. Immunohistochemical studies showed positive NSE staining in lung biopsy specimen.Conclusions Serum NSE and CA125 concentrations would provide valuable clinical information to assess disease severity in silicosis.
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“Nonspecific serum markers of inflammation and tumor biomarkers might have utility in screening and/or trending levels of disease severity, though they would help little in ascertaining the diagnosis or determining the level of functional impairment68,69.”
From Overview of lunar dust toxicity risk (2022) · cites this paper as [68]
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Cited by
Overview of lunar dust toxicity risk
Pohlen, M., Carroll, D., Prisk, G. K., & Sawyer, A. J. (2022) · npj Microgravity · doi:10.1038/s41526-022-00244-1 · Cited by 72
Metadata
- Authors
- Fang, S.-C., Zhang, H.-T., Wang, C.-Y., & Zhang, Y.-M.
- Affiliations
- Nanjing Chest Hospital (CN)
- Corresponding author
- Zhang, Ying-Ming
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 433
- Pages
- 123-127
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2020760718
- Cited by
- 28
- References
- 17
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nanjing Health Bureau (ZKK12036)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoidosis and Beryllium Toxicity Research
- Keywords
- silicosis, CA125, neuron-specific enolase, tumor markers, disease severity, serum biomarkers, bronchoalveolar lavage, lung lavage, lactate dehydrogenase, lung function, lung biopsy
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Humans, Male, Middle Aged, Phosphopyruvate Hydratase, Silicosis, Biomarkers, Tumor, Case-Control Studies, CA-125 Antigen
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