Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction
Abstract
Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria. Furthermore, in cardiac patients, plasma CoQ10 has been found to be an independent predictor of mortality. Based on the fundamental role of CoQ10 in mitochondrial bioenergetics and its well-acknowledged antioxidant properties, several clinical trials evaluating CoQ10 have been undertaken in cardiovascular disorders of ageing including chronic heart failure, hypertension, and endothelial dysfunction. CoQ10 as a therapy appears to be safe and well tolerated.
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Numerous studies have shown that intake of exogenous CoQ10 could help prevent progression of illness such as heart failure, metabolic syndrome, NAFLD, diabetes mellitus, and several neurodegenerative diseases.
“Numerous studies have shown that the intake of exogenous CoQ10 could help to prevent the progression of illness, such as heart failure, metabolic syndrome, NAFLD, diabetes mellitus, and several neurodegenerative diseases177,181–186.”
CoQ10 is able to reduce superoxide production in mitochondria.
“It is a fat-soluble micronutrient synthesized by all human cells and tissues that can also be taken exogenously to mitigate ROS damage, as CoQ10 is able to reduce superoxide production in mitochondria176,177.”
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References 77 · Cited by 78
- Authors
- Yang, Y.-K., Wang, L.-P., Chen, L., Yao, X.-P., Yang, K.-Q., Gao, L.-G., & Zhou, X.-L.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese People's Liberation Army (CN)
- Chinese PLA General Hospital (CN)
- Corresponding author
- Gao, Ling-Gen
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 450
- Pages
- 83-89
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W1097637809
- Cited by
- 78
- References
- 77
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 16 · 2020: 15 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (2012T50865)
- Beijing Science and Technology Program (Z131100002613006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- coenzyme Q10, cardiovascular aging, heart failure, hypertension, endothelial dysfunction, mitochondrial dysfunction, oxidative stress, antioxidant therapy, mortality prediction, drug safety
- MeSH terms
- Aging, Antioxidants, Heart Failure, Humans, Hypertension, Ubiquinone, Endothelial Cells
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