Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults
Abstract
Background We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults.Methods Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12months postoperatively.Results Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12months in non-DM group, while improving significantly at 6 and 12months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12months in non-DM group and 12months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6.Conclusion Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
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Weight loss from metabolic surgery resulted in reductions in CRP at 3, 6, and 12 months in nondiabetic patients, whereas patients with diabetes showed significant CRP reductions only at 12 months.
“In a study, weight loss from metabolic surgery resulted in reductions in CRP in the third, sixth, and twelfth month after the procedure in nondiabetic patients whereas significant reductions in CRP were observed in patients with diabetes only 12 months after bariatric surgery [17].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [17]
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References 40 · Cited by 25
- Authors
- Shih, K.-C., Janckila, A. J., Lee, W.-J., Chou, Y.-C., Huang, C.-J., Kwok, C.-F., Ho, L.-T., & Chao, T.-Y.
- Affiliations
- Tri-Service General Hospital (TW)
- University of Louisville (US)
- National Taiwan University (TW)
- National Defense Medical Center (TW)
- Taipei Veterans General Hospital (TW)
- National Yang Ming University (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Corresponding author
- Shih, Kuang-Chung
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 453
- Pages
- 197-202
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2154486045
- Cited by
- 25
- References
- 40
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tri-Service General Hospital (TSGH-C96-5-S03)
- National Health Research Institutes (BS-096-PP-01)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- bariatric surgery, morbid obesity, glucose metabolism, insulin resistance, inflammatory cytokines, C-reactive protein, interleukin-6, lipid profile, LDL cholesterol, type 2 diabetes, Chinese adults
- MeSH terms
- Tartrate-Resistant Acid Phosphatase, Acid Phosphatase, Adult, Blood Glucose, C-Reactive Protein, Female, Humans, Inflammation, Insulin Resistance, Isoenzymes, Lipids, Male, Obesity, Weight Loss, Case-Control Studies, Cytokines, Asian People, Bariatric Surgery
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