Biological variation estimates for prostate specific antigen from the European Biological Variation Study; consequences for diagnosis and monitoring of prostate cancer

Carobene, Anna; Guerra, Elena; Locatelli, Massimo; Cucchiara, Vito; Briganti, Alberto; Aarsand, Aasne K.; Coşkun, Abdurrahman; Díaz-Garzón, Jorge; Fernandez-Calle, Pilar; Røraas, Thomas; Sandberg, Sverre; Jonker, Niels; Ceriotti, Ferruccio

doi:10.1016/j.cca.2018.07.043

Biological variation estimates for prostate specific antigen from the European Biological Variation Study; consequences for diagnosis and monitoring of prostate cancer

BACKGROUND Prostate-specific antigen (PSA) is central in the diagnosis of prostate cancer. However, high-quality biological variation (BV) estimates for PSA are scarce. Here BV estimates from the European Biological Variation Study (EuBIVAS) for total (tPSA), free (fPSA), conjugated PSA (cPSA), a…