Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

Broz, Miranda L.; Binnewies, Mikhail; Boldajipour, Bijan; Nelson, Amanda E.; Pollack, Joshua L.; Erle, David J.; Barczak, Andrea; Rosenblum, Michael D.; Daud, Adil; Barber, Diane L.; Amigorena, Sebastian; van’t Veer, Laura J.; Sperling, Anne I.; Wolf, Denise M.; Krummel, Matthew F.

doi:10.1016/j.ccell.2014.09.007

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

SUMMARY It is well understood that antigen-presenting cells (APC) within tumors typically do not maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse tumor models and human tumor biopsies, we have delineated the intratumoral dendritic-cell (DC) populations as dis…