Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

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5. Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells
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8. Splicing factor mutant myelodysplastic syndromes: Recent advances
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9. PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer
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12. Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome
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14. The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations
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15. Impact of alternative splicing on mechanisms of resistance to anticancer drugs
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16. Molecular correlates of anemia in primary myelofibrosis: a significant and independent association with U2AF1 mutations
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17. Clonal evolution and hierarchy in myeloid malignancies
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18. Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches
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19. Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature
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20. An Intricate Connection between Alternative Splicing and Phenotypic Plasticity in Development and Cancer
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21. SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis
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22. The Biological and Clinical Consequences of RNA Splicing Factor U2AF1 Mutation in Myeloid Malignancies
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23. Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunities
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24. Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer
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25. Mutations of RNA splicing factors in hematological malignancies
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26. Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences
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27. Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia
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28. Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation
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29. Genetic Aspects of Myelodysplastic/Myeloproliferative Neoplasms
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30. Prognostic value of U2AF1 mutant in patients with de novo myelodysplastic syndromes: a meta-analysis
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31. U2AF1 mutation promotes tumorigenicity through facilitating autophagy flux mediated by FOXO3a activation in myelodysplastic syndromes
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32. Discovery of U2AF1 neoantigens in myeloid neoplasms
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33. Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control
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34. RNA splicing, cell signaling, and response to therapies
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35. Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes
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36. Targeting alternative splicing in cancer immunotherapy
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37. Age-Related Alternative Splicing: Driver or Passenger in the Aging Process?
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38. Splicing Anomalies in Myeloproliferative Neoplasms: Paving the Way for New Therapeutic Venues
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39. CHIP: a clonal odyssey of the bone marrow niche
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40. Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice
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41. lncRNA ZFAS1 Promotes HMGCR mRNA Stabilization via Binding U2AF2 to Modulate Pancreatic Carcinoma Lipometabolism
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42. Phase 1 study of JNJ-64619178, a protein arginine methyltransferase 5 inhibitor, in patients with lower-risk myelodysplastic syndromes
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43. SF3B1 mutant myelodysplastic syndrome: Recent advances
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44. U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice
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45. Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms
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46. Smc3 is required for mouse embryonic and adult hematopoiesis
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47. Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
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48. Ultrasensitive Detection of RNA with Single-Base Resolution by Coupling Electrochemical Sensing Strategy with Chimeric DNA Probe-Aided Ligase Chain Reaction
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49. ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells
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50. The Coming of Age of Preclinical Models of MDS
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51. Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment
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52. Transplant Decisions in Patients with Myelofibrosis: Should Mutations Be the Judge?
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53. Therapeutic approaches to treat human spliceosomal diseases
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54. Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control
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55. mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control
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56. Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations
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57. HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis
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58. ATP5A1 Participates in Transcriptional and Posttranscriptional Regulation of Cancer-Associated Genes by Modulating Their Expression and Alternative Splicing Profiles in HeLa Cells
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59. U2AF1 and EZH2 mutations are associated with nonimmune hemolytic anemia in myelodysplastic syndromes
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60. Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia
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61. Recurrent Spliceosome Mutations in Cancer: Mechanisms and Consequences of Aberrant Splice Site Selection
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62. Emerging biological therapies for the treatment of myelodysplastic syndromes
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63. Aspartyl-tRNA synthetase 2 orchestrates iron-sulfur metabolism in hematopoietic stem cells via fine-tuning alternative RNA splicing
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64. Biological relevance of alternative splicing in hematologic malignancies
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65. Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal
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66. The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5′ splice site that impacts splicing regulation in Q157R patients
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67. A genetic development route analysis on MDS subset carrying initial epigenetic gene mutations
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69. Targeting Aberrant Splicing in Myelodysplastic Syndromes
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70. Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms
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73. Integrative Profiling of Alternative Splicing Induced by U2AF1 S34F Mutation in Lung Adenocarcinoma Reveals a Mechanistic Link to Mitotic Stress.
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79. Therapeutic targeting of RNA splicing in myelodysplasia
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80. Molecular landscape in acute myeloid leukemia: where do we stand in 2016
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81. Stem Cells in the Myelodysplastic Syndromes
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84. RNA splicing as a therapeutic target in myelodysplastic syndromes
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85. Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias
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93. U2AF1 mutation connects DNA damage to the alternative splicing of RAD51 in lung adenocarcinomas
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