Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate
Open accessAbstract
Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.
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De-differentiation is exemplified by colon carcinogenesis due to loss of HOXA5 and SMAD4, melanomagenesis due to loss of MITF, and pancreatic neuroendocrine tumors due to loss of a differentiation-inducing miRNA in beta cells.
“De-differentiation is exemplified by colon carcinogenesis (due to the loss of the differentiation-inducing transcription factor HOXA5 and SMAD4), 141,142 melanomagenesis (due to the loss of the transcription factor MITF), 143 or pancreatic neuroendocrine tumors (due to the loss of a differentiation-inducing miRNA in b cells).144”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [141]
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References 9 · Cited by 29
- Authors
- Tan, S. H., & Barker, N.
- Affiliations
- Institute of Medical Biology (SG)
- National University of Singapore (SG)
- Corresponding author
- Barker, Nick
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 28
- Issue
- 6
- Pages
- 683-685
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2205913796
- Cited by
- 29
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 2 · 2016: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- colorectal cancer, cancer stem cells, HOXA5, Wnt signaling, cancer stem cell differentiation, metastasis, tumor growth, therapeutic targeting
- MeSH terms
- Animals, Female, Humans, Intestinal Mucosa, Male, Phosphoproteins, Neoplastic Stem Cells, Colorectal Neoplasms, Homeodomain Proteins, Wnt Signaling Pathway
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