Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
Eggert, Tobias, Wolter, Katharina, Ji, Juling, Ma, Chi, Yevsa, Tetyana, Klotz, Sabrina, Medina-Echeverz, José, Longerich, Thomas +6 more·2016·Cancer Cell
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- Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancerYuewen Kuang, Mingkun Jia, Yuming Zhu, Zhiyong Xiang · 2026 · PeerJ
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- Cell and gene therapiesMehmet Tosun, Mark A. Schenerman · 2026 · Elsevier eBooks
- Modulation de la sénescence induite par les oncogènes par les glucocorticoïdes et rôle de EGR1Cyril Carvalho · 2018
- Advanced drug delivery platforms targeting cellular senescence: A promising strategy for cancer therapyXue Zhang, Lingxiao Yang, Xiaopeng He, Min Zhao, Zaixiang Fang, Gang Xu, Zhenyu Duan, Kui Luo · 2026 · Acta Pharmaceutica Sinica B
- Monoacylglycerol Lipase, a new anti-inflammatory and anti-fibrogenic target in the liverDina Chokr · 2018 · theses.fr (ABES)
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- Dissecting the non-cell autonomous impact of cellular senescence on cellular reprogrammingMathieu von Joest · 2019 · theses.fr (ABES)
- Contrôle du développement et de la progression du carcinome hépatocellulaire par l’autophagie des macrophages : rôle du micro-environnement immunitaireAnthony Deust · 2020
- Metabolic homeostasis and regulatory mechanisms of cellular senescence : roles of ITPR2-mediated calcium fluxes and mevalonate pathwayDorian V. Ziegler · 2020
- Rôle de LECT2 dans les maladies stéatosiques non alcooliques du foieSandrine Pham · 2020 · theses.fr (ABES)
- Effet anti-tumoral du GTN +/- doxorubicine dans le cancer du sein triple négatif : implication du système immunitaireNesrine Mabrouk · 2021 · theses.fr (ABES)
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