The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
Open accessAbstract
SUMMARY Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that, in order to be realized, must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonstrate that the cell surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target. In preclinical studies CD276-ADCs armed with a conventional MMAE warhead destroyed CD276-positive cancer cells, but were ineffective against tumor vasculature. In contrast, pyrrolobenzodiazepine-conjugated CD276-ADCs killed both cancer cells and tumor vasculature, eradicating large established tumors and metastases, and improving long-term overall survival. CD276 targeted dual-compartment ablation could aid in development of highly selective broad-acting anti-cancer therapies.
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Costa, A., Kieffer, Y., Scholer-Dahirel, A., Pelon, F., Bourachot, B., Cardon, M., Sirven, P., Magagna, I., Fuhrmann, L., Bernard, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.011 · Cited by 1,705
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Metadata
- Authors
- Seaman, S., Zhu, Z., Saha, S., Zhang, X. M., Yang, M. Y., Hilton, M. B., Morris, K., Szot, C., Morris, H., Swing, D. A., Tessarollo, L., Smith, S. W., Degrado, S., Borkin, D., Jain, N., Scheiermann, J., Feng, Y., Wang, Y., Li, J., Welsch, D., DeCrescenzo, G., Chaudhary, A., Zudaire, E., Klarmann, K. D., Keller, J. R., Dimitrov, D. S., & St. Croix, B.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 31
- Issue
- 4
- Pages
- 501-515.e8
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2606786998
- Cited by
- 423
- References
- 41
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Seaman, S., Zhu, Z., Saha, S., Zhang, X. M., Yang, M. Y., Hilton, M. B., Morris, K., Szot, C., Morris, H., Swing, D. A., Tessarollo, L., Smith, S. W., Degrado, S., Borkin, D., Jain, N., Scheiermann, J., Feng, Y., Wang, Y., Li, J., . . . St. Croix, B. (2017). Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.03.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
