H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas

Pathania, Manav, De Jay, Nicolas, Maestro, Nicola, Harutyunyan, Ashot S., Nitarska, Justyna, Pahlavan, Pirasteh, Henderson, Stephen, Mikael, Leonie G. +14 more·2017·Cancer Cell

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Items 101–200 of 265

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  2. Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma
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  5. Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease
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  7. H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes
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  9. CDK4/6 and PDGFRA Signaling as Therapeutic Targets in Diffuse Intrinsic Pontine Glioma
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  10. IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation
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  12. Preclinical therapeutic targets in diffuse midline glioma
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  13. Histone-Mutant Glioma: Molecular Mechanisms, Preclinical Models, and Implications for Therapy
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  14. Radiosensitization in Pediatric High-Grade Glioma: Targets, Resistance and Developments
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  15. H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans
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  16. Histone isoforms and the oncohistone code
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  17. Oncohistones in brain tumors: the soil and seed
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  19. The H3.3K27M oncohistone antagonizes reprogramming in Drosophila
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  30. Histone H3K27M Mutation in Brain Tumors
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