The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
Open accessAbstract
Summary ARID1A, a SWI/SNF chromatin remodeling gene, is commonly mutated in cancer and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients, ARID1A was highly expressed in primary tumors but not in metastatic lesions, suggesting that ARID1A can be lost after initiation. Mice with liver-specific homozygous or heterozygous Arid1a loss were resistant to tumor initiation while ARID1A overexpression accelerated initiation. In contrast, homozygous or heterozygous Arid1a loss in established tumors accelerated progression and metastasis. Mechanistically, gain of Arid1a function promoted initiation by increasing Cytochrome P450 mediated oxidative stress, while loss of Arid1a within tumors decreased chromatin accessibility and reduced transcription of genes associated with migration, invasion, and metastasis. In summary, ARID1A has context-dependent tumor suppressive and oncogenic roles in cancer.
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Metadata
- Authors
- Sun, X., Wang, S. C., Wei, Y., Luo, X., Jia, Y., Li, L., Gopal, P., Zhu, M., Nassour, I., Chuang, J.-C., Maples, T., Celen, C., Nguyen, L. H., Wu, L., Fu, S., Li, W., Hui, L., Tian, F., Ji, Y., Zhang, S., Sorouri, M., Hwang, T. H., Letzig, L., James, L., Wang, Z., Yopp, A. C., Singal, A. G., & Zhu, H.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 32
- Issue
- 5
- Pages
- 574-589.e6
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2770519623
- Cited by
- 253
- References
- 7
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, X., Wang, S. C., Wei, Y., Luo, X., Jia, Y., Li, L., Gopal, P., Zhu, M., Nassour, I., Chuang, J.-C., Maples, T., Celen, C., Nguyen, L. H., Wu, L., Fu, S., Li, W., Hui, L., Tian, F., Ji, Y., . . . Zhu, H. (2017). Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2017.10.007
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