Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

Hellmann, Matthew D.; Nathanson, Tavi; Rizvi, Hira; Creelan, Benjamin C.; Sanchez-Vega, Francisco; Ahuja, Arun; Ni, Ai; Novik, Jacki B.; Mangarin, Levi M.B.; Abu-Akeel, Mohsen; Liu, Cailian; Sauter, Jennifer L.; Rekhtman, Natasha; Chang, Eliza; Callahan, Margaret K.; Chaft, Jamie E.; Voss, Martin H.; Tenet, Megan; Li, Xue-Mei; Covello, Kelly; Renninger, Andrea; Vitazka, Patrik; Geese, William J.; Borghaei, Hossein; Rudin, Charles M.; Antonia, Scott J.; Swanton, Charles; Hammerbacher, Jeff; Merghoub, Taha; McGranahan, Nicholas; Snyder, Alexandra; Wolchok, Jedd D.

doi:10.1016/j.ccell.2018.03.018

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

Summary Combination immune checkpoint blockade has demonstrated promising benefit in lung cancer, but predictors of response to combination therapy are unknown. Using whole exome sequencing to examine non-small cell lung cancer (NSCLC) treated with PD-1 plus CTLA-4 blockade, we found that high tu…