The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer
Open accessAbstract
SUMMARY Durable responses and encouraging survival have been demonstrated with immune checkpoint inhibitors in small cell lung cancer (SCLC), but predictive markers are unknown. We used whole exome sequencing to evaluate the impact of tumor mutation burden (TMB) on efficacy of nivolumab monotherapy or combined with ipilimumab in patients with SCLC from the nonrandomized or randomized cohorts of CheckMate 032. Patients received nivolumab (3 mg/kg every 2 weeks) or nivolumab plus ipilimumab (1 mg/kg plus 3 mg/kg every 3 weeks for four cycles, followed by nivolumab 3 mg/kg every 2 weeks). Efficacy of nivolumab ± ipilimumab was enhanced in patients with high TMB. Nivolumab plus ipilimumab appeared to provide a greater clinical benefit than nivolumab monotherapy in the high TMB tertile.
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Self-citationThe evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
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The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker
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“…et al., 2016; Shitara et al., 2018; Siefker-Radtke et al., 2018) Unfortunately, ICIs can also cause a number of unique immunerelated toxicities (Patel and Kurzrock, 2015; Postow and Hellmann, 2018) as well as accelerated progression, termed hyperprogression, in a subset of treated individuals.”
Background
Metadata
- Authors
- Hellmann, M. D., Callahan, M. K., Awad, M. M., Calvo, E., Ascierto, P. A., Atmaca, A., Rizvi, N. A., Hirsch, F. R., Selvaggi, G., Szustakowski, J. D., Sasson, A., Golhar, R., Vitazka, P., Chang, H., Geese, W. J., & Antonia, S. J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 33
- Issue
- 5
- Pages
- 853-861.e4
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2800160190
- Cited by
- 893
- References
- 33
- FWCI
- 45.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hellmann, M. D., Callahan, M. K., Awad, M. M., Calvo, E., Ascierto, P. A., Atmaca, A., Rizvi, N. A., Hirsch, F. R., Selvaggi, G., Szustakowski, J. D., Sasson, A., Golhar, R., Vitazka, P., Chang, H., Geese, W. J., & Antonia, S. J. (2018). Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2018.04.001
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