Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting
Srivastava, Shivani, Salter, Alexander I., Liggitt, Denny, Yechan-Gunja, Sushma, Sarvothama, Megha, Cooper, Kirsten, Smythe, Kimberly S., Dudakov, Jarrod A. +3 more·2019·Cancer Cell
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- Efficient Production of Chimeric Antigen Receptor (CAR) T Cells with Transgenes Exceeding 10 kb Using Lentiviral VectorsPhilipp C. Rommel, Nils W. Engel, Bruce L. Levine, Carl H. June · 2026 · Journal of Visualized Experiments
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- Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor TherapyMiao Zhang, Quan Zhang, Xin Yu, Yuhui Yan, Yueting Yu, Guangna Liu, Fenglin Wang, Xia Chu, Jian-Hui Jiang · 2026 · Angewandte Chemie
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- The potential of B7-H3 as a new target for CAR-T therapy: Advancements, challenges and clinical perspectivesJuelan Ye, Jingjing Sun, Jiafeng Hou, L X Zhang, Chunbiao Wu, Jianru Xiao · 2026 · Cancer Treatment and Research Communications
- Engineering CAR-T cells for solid tumors: overcoming antigenic, trafficking, and microenvironmental barriersZiyan Kong, Jinke Wang · 2026 · Frontiers in Immunology
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- Current therapeutic interventions to target cancer stem cells for metastasisPriyancka Arora, Rakesh Bhatia, Sheetal Sharma, Anupam Sharma, Subhash C. Chauhan, Jagmohan Singh, A. Sharma · 2026 · International Journal of Clinical Oncology
- Logic-gated CARs: a unified framework for programmable cell-based delivery systemsPu-Sheng Wei, Zitao Ma, Evelyn Chang, Yu-Hsuan Tsai, Kuo‐Ching Mei · 2026 · Trends in biotechnology
- De novo discovery of a potent ROR1-binding macrocyclic peptide and its evaluation as a novel imaging probePeiying Li, Tao Yang, Zhenxin Ma, Yujie Wu, Xing Cheng, Chunmei An, Ningning Pang, Zhide Guo, Xiaochun Xiong · 2026 · Chinese Chemical Letters
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- Multipronged enhancement of CART cell activity against ROR1 neoantigen by inhibition of H3K27 methyltransferase EZH2Shengchun Wang, Cosimo Lobello, Pradeep Gupta, Roniya Francis, Aldana Vistarop, Bhaumik Shah, Sergio Zamora-Erazo, Fahad Ahmed, David Rushmore, Andrew Kalgren et al. · 2026 · Cell Reports Medicine
- CAR-T cell therapy for solid tumors: antigen landscape, biological barriers, and engineering strategies for clinical translationQian Niu, Meng Li, Chengyi Zhang, Qian Li, Meng Wang, Andong Liu · 2026 · Frontiers in Immunology
- Toward the next generation of CAR T cell therapies for cancerDiren Usta, Crystal Lee Mackall · 2026 · Cancer Cell
- Neoantigenic receptor ROR1 promotes cell growth through diverse and complementary mechanismsShengchun Wang, Shilpa Rao, Cosimo Lobello, David Rushmore, Bhaumik Shah, Suzanne Paley, Pradeep Kumar Gupta, Andrew Kalgren, Dinesh Singh, Neil V. Sen et al. · 2026 · Leukemia
- Synthetic Notch CD123 and CLL1 chimeric antigen receptor T-cells (CAR-T) target acute myeloid leukemia and reduce off-tumor effects associated with CLL1 CAR-T cellsRui Zhang, Na Chen, Mengnan Li, Qingxi Liu, Mingfeng Zhao · 2026 · Molecular Biomedicine
- DNA Logic-Gated Biosensing of the Tumor Microenvironment for Multicomponent Profiling and Programmable Molecular Decision-MakingMinghan Li, Yinuo Chen, Yihang Du, Yicong Li, Jinpeng Shi, Jie Tong, Yinan Li, Jiashuang Xu, Qiuyue Wu, Shengyuan Deng et al. · 2026 · Chemosensors
- Innovations and emerging trends in adoptive cell therapies for solid tumors: engineering strategies and clinical translationPeng Huang, WenLin Wu, Yu Min, Yi Zhang, YunFeng Tao, Zheran Liu, Zhigong Wei, Xingchen Peng · 2026 · Experimental Hematology and Oncology
- BindingDB Entry 50023829: Optimization of 1-Methyl-3-(pyridin-3-yl)-1H-indol Derivatives as ROR1 Inhibitors with Improved Activity and Selectivity.BindingDB · 2026 · UC San Diego
- Key Considerations for In Vitro Assessment of On- and Off-target/ Off-Disease Effects of Chimeric Antigen Receptor T-Cell TherapiesShari A. Price, Alberto del Rio, George Papadopoulos, Jonathan M. Clingan, Yi Yang, Louise S. Brackenbury, Sara Compte Sancerni, David Cobeta Lopez, Sabrina de Munnik, Louise Delsing et al. · 2026 · Cytotherapy
- From telomere dysfunction to seno-antigen selection: a conceptual framework and route-specific evidence appraisal for senolytic immunotherapySarfaraz K. Niazi · 2026 · Frontiers in Systems Biology