KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer

Liao, Wenting, Overman, Michael J., Boutin, Adam T., Shang, Xiaoying, Zhao, Di, Dey, Prasenjit, Li, Jiexi, Wang, Guocan +19 more·2019·Cancer Cell

Cited by (619)

Items 301–400 of 619

  1. Colorectal cancer: epidemiology, carcinogenesis, molecular subtypes and cellular mechanisms of therapy resistance (analytical review)
    P. E. Maksimova, Elena Petrovna Golubinskaya, Сеферов Бекир Джелялович, Evgeniya Yu. Zyablitskaya · 2023 · Koloproktologia
  2. Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential
    Eric Jou · 2023 · Exploration of Targeted Anti-tumor Therapy
  3. Exploring the potential mechanisms of Yi-Yi-Fu-Zi-Bai-Jiang-San therapy on the immune-inflamed phenotype of colorectal cancer via combined network pharmacology and bioinformatics analyses
    Yong Liu, Youcheng Liang, Yongjian Su, Jiaqi Hu, Jianbo Sun, Mingbin Zheng, Zunnan Huang · 2023 · Computers in Biology and Medicine
  4. Suppressive Myeloid Cells Shape the Tumor Immune Microenvironment
    Jia Xiong, Hui Wang, Qingqing Wang · 2021 · Advanced Biology
  5. Tumor microenvironment-adjusted prognostic implications of the KRAS mutation subtype in patients with stage III colorectal cancer treated with adjuvant FOLFOX
    Hye Eun Park, Seung-Yeon Yoo, Nam‐Yun Cho, Jeong Mo Bae, Sae‐Won Han, Hye Seung Lee, Kyu Joo Park, Tae‐You Kim, Gyeong Hoon Kang · 2021 · Scientific Reports
  6. What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis?
    Milena Peruhova, Monika Peshevska-Sekulovska, Boris Milev Krastev, Gabriela Georgieva Panayotova, Viktoriya Georgieva, Rossitza Konakchieva, Georgi Nikolaev, Tsvetelina Veselinova Velikova · 2020 · World Journal of Gastroenterology
  7. Recent Advances in Our Knowledge of mCRC Tumor Biology and Genetics: A Focus on Targeted Therapy Development
    Gmeiner, William H · 2021 · OncoTargets and Therapy
  8. Current status of KRAS G12C inhibitors in NSCLC and the potential for combination with anti-PD-(L)1 therapy: a systematic review
    Fan Zhang, Banglu Wang, Menghuan Wu, Liwen Zhang, Mei Qing Ji · 2025 · Frontiers in Immunology
  9. Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer
    Sheng-Nan Ren, Zhan-Yi Zhang, Rui-Jie Guo, Daren Wang, Fangfang Chen, Xuebo Chen, Xuedong Fang · 2023 · World Journal of Gastroenterology
  10. A muti-modal feature fusion method based on deep learning for predicting immunotherapy response
    Xiong Li, Xuan Feng, Juan Zhou, Yuchao Luo, Xiao Chen, Jiapeng Zhao, Haowen Chen, Guoming Xiong, Guoliang Luo · 2024 · Journal of Theoretical Biology
  11. The Role of Interferon Regulatory Factors in Liver Diseases
    Chuanfei Zeng, Xiaoqin Zhu, Huan Li, Ziyin Huang, Mingkai Chen · 2024 · International Journal of Molecular Sciences
  12. KRAS mutations are negatively correlated with immunity in colon cancer
    Xiaorui Fu, Xinyi Wang, Jinzhong Duanmu, Taiyuan Li, Qunguang Jiang · 2020 · Aging
  13. HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells
    Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao, Qing Wang · 2022 · Cancer Cell International
  14. Targeting TIME in advanced hepatocellular carcinoma: Mechanisms of drug resistance and treatment strategies
    Xinyi Ye, Xizhu Fang, Fangfang Li, Dan Jin · 2025 · Critical Reviews in Oncology/Hematology
  15. Unveiling the tumor microenvironment in colorectal cancer therapeutic resistance
    Jiyu Han, Weitian Liang, Kai Li · 2026 · Frontiers in Cell and Developmental Biology
  16. Regulation of signal transduction pathways in colorectal cancer: implications for therapeutic resistance
    Yeelon Yeoh, Teck Yew Low, Nadiah Abu, Pey Yee Lee · 2021 · PeerJ
  17. FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer
    Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao et al. · 2022 · Frontiers in Oncology
  18. KRAS inhibition in metastatic colorectal cancer: An update
    Maliha Nusrat, Rona D. Yaeger · 2023 · Current Opinion in Pharmacology
  19. LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche
    Xianying Li, Shuhang Liang, Mingming Fei, Kun Ma, Linmao Sun, Yao Liu, Lianxin Liu, Jiabei Wang · 2024 · International Journal of Biological Sciences
  20. Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review
    Alessandra Cesano, Ryan C. Augustin, Luigi Barrea, Davide Bedognetti, Tullia Carmela Bruno, Alberto Carturan, Christian Hammer, Winson S. Ho, Jakob Nikolas Kather, Tomas Kirchhoff et al. · 2025 · Journal for ImmunoTherapy of Cancer
  21. USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment
    Shuling Han, Luying Cui, Bojun Wang, Yuli Ruan, Mengde Shi, Chang Sook Hong, Xin Guan, Zhuo Chen, Yingjue Li, Yuanyu Liao et al. · 2025 · Cancer Immunology Research
  22. Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment
    Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai · 2025 · Advanced Science
  23. RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma
    Larissa Anastácio da Costa Carvalho, Nataliya Tovbis Shifrin, Manali S. Phadke, Michael F. Emmons, Ximo Pechuan-Jorge, Felix Mbuga, Oscar E. Ospina, Christopher Chow, Lillian Seu, Olivia L. Rose et al. · 2025 · Cancer Immunology Research
  24. Conquering oncogenic KRAS and its bypass mechanisms
    Pingping Hou, Yanru Wang · 2022 · Theranostics
  25. A novel prognostic signature based on cuproptosis-related lncRNA mining in colorectal cancer
    Dong Hou, Jia-nan Tan, Shengning Zhou, Yang Xu, Zhihong Zhang, Guangyu Zhong, Lin Zhong, Bin Yang, Fanghai Han · 2022 · Frontiers in Genetics
  26. Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice
    Qing Kong, Huahe Zhu, Weiyi Gong, Xiaohong Deng, Baojun Liu, Jingcheng Dong · 2023 · Journal of Ethnopharmacology
  27. An updated overview of K-RAS G12C inhibitors in advanced stage non-small cell lung cancer
    Ateş Kutay Tenekeci, Ahmet Arda Unal, Furkan Ceylan, Mehmet Ali Nahit Sendur · 2024 · Future Oncology
  28. Immune-associated biomarkers for early diagnosis of Parkinson’s disease based on hematological lncRNA–mRNA co-expression
    Kecheng Lei, Liwen Zhang, Yijing He, Hui Sun, Weifang Tong, Yichun Xu, Lingjing Jin · 2020 · Bioscience Reports
  29. Targeting DRP1 promotes radiotherapy-induced antitumor immunity via mitochondrial DNA-mediated cGAS-STING signaling in KRAS-mutated colorectal cancer
    Yuan‐Yao Tsai, Hsin-Yu Chang, Wei-Ze Hong, Jhen-Yu Chen, Shu‐Fen Chiang, Yusen Eason Lin, Tao-Wei Ke, Chi-Hsien Huang, Te-Hung Chen, Yiwen Jiang et al. · 2025 · Cancer Letters
  30. Prediction and identification of immune genes related to the prognosis of patients with colon adenocarcinoma and its mechanisms
    Sihan Chen, Guodong Cao, Wei Wu, Yida Lu, Xiaobo He, Yang Lei, Ke Chen, Bo Chen, Maoming Xiong · 2020 · World Journal of Surgical Oncology
  31. Towards a precision immune checkpoint blockade immunotherapy in patients with colorectal cancer: Strategies and perspectives
    Guanglin Cui · 2022 · Biomedicine & Pharmacotherapy
  32. Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways
    Barbara Seliger, Chiara Massa · 2022 · Frontiers in Immunology
  33. Co-dependencies in the tumor immune microenvironment
    Peiwen Chen, Prasenjit Dey · 2022 · Oncogene
  34. HOXC10 Promotes Metastasis in Colorectal Cancer by Recruiting Myeloid-derived Suppressor Cells
    Jiao Yu, Xiaojiao Chen, Shuhong Zhao, Jingchen Jing, Qing Wang, Yunzhi Dang · 2022 · Journal of Cancer
  35. Sintilimab plus bevacizumab and CapeOx (BBCAPX) on first-line treatment in patients with RAS mutant, microsatellite stable, metastatic colorectal cancer: study protocol of a randomized, open-label, multicentric study
    Xuefeng Fang, Chenhan Zhong, Shanshan Weng, Hanguang Hu, Jian Wang, Qian Xiao, Jianwei Wang, Lifeng Sun, Dong Xu, Xiujun Liao et al. · 2023 · BMC Cancer
  36. Glutamic-pyruvic transaminase 1 deficiency–mediated metabolic reprogramming facilitates colorectal adenoma-carcinoma progression
    Li Xiong, Xin Yang, Huashan Liu, Xianrui Wu, Tanxing Cai, Ming Yuan, Liang Huang, Chi Zhou, Xiaobin Zheng, Wenxin Li et al. · 2025 · Science Translational Medicine
  37. Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
    Imran Khan, Catherine B. MarElia, Julia E. Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M. Connor, Ann‐Marie Broome, Thierry Pécot, Cynthia Dawn Timmers et al. · 2021 · Small GTPases
  38. Expression levels of chemokine (C-X-C motif) ligands CXCL1 and CXCL3 as prognostic biomarkers in rectal adenocarcinoma: evidence from Gene Expression Omnibus (GEO) analyses
    Qiyuan Lv, Haizhou Zou, Yuyan Xu, Zhenyong Shao, Ruoqi Wu, Kejie Li, Xia Deng, Dian-na Gu, Hong-xiao Jiang, Meng Su et al. · 2021 · Bioengineered
  39. Checkpoint molecules on infiltrating immune cells in colorectal tumor microenvironment
    Iman Mamdouh Talaat, Noha Mousaad Elemam, Shroque Zaher, Maha Mohamed Saber-Ayad · 2022 · Frontiers in Medicine
  40. GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
    Yannick Sebastiaan Rakké, Lucia Campos Carrascosa, Adriaan A. van Beek, Valeska de Ruiter, Rachelle S. van Gemerden, Michail Doukas, Pascal Gabriël Doornebosch, Maarten Vermaas, Susan ter Borg, Erwin van der Harst et al. · 2022 · Cellular and Molecular Gastroenterology and Hepatology
  41. Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer
    Yun Yang, Yong Wu, Xin Guo, Wen-Juan Gan, Wen-Xin Wu, Wei-Yi Shi, Xiaoshun He, Yi-Xuan Liu, Shan Wan, Zhi Jiang et al. · 2026 · Nature Metabolism
  42. Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer
    Hang Ruan, Brian J. Leibowitz, Yingpeng Peng, Lin Shen, Lujia Chen, Charlie Kuang, Robert E. Schoen, Xinghua Lu, Lin Zhang, Jian Yu · 2022 · Molecular Biomedicine
  43. Interplay between the Human Microbiome and Biliary Tract Cancer: Implications for Pathogenesis and Therapy
    Cheng Ye, Chunlu Dong, Yanyan Lin, Huaqing Shi, Wence Zhou · 2023 · Microorganisms
  44. Targeting KRAS Oncogene for Patients With Colorectal Cancer: A New Step Toward Precision Medicine
    İbrahim Halil Şahin, Turçin Saridogan, Rüveyda Ayasun, Masood Pasha Syed, Vikram C. Gorantla, Monica Khunger Malhotra, Roby Antony Thomas, John C. Rhee, Janie Yue Zhang, Dennis J. Hsu et al. · 2024 · JCO Oncology Practice
  45. Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment
    Hideyuki Masui, Kenji Kawada, Yoshiro Itatani, Hideyo Hirai, Yuki Nakanishi, Yoshiyuki Kiyasu, Keita Hanada, Michio T. OKAMOTO, Wataru Hirata, Yasuyo Nishikawa et al. · 2024 · British Journal of Cancer
  46. Optimizing hybrid ensemble feature selection strategies for transcriptomic biomarker discovery in complex diseases
    Elsa Claude, Mickaël Leclercq, Patricia Thébault, Arnaud Droit, Raluca Uricaru · 2024 · NAR Genomics and Bioinformatics
  47. Comprehensive clinicopathologic, molecular, and immunologic characterization of colorectal carcinomas with loss of three intestinal markers, CDX2, SATB2, and KRT20
    Ji Ae Lee, Mi-Kyoung Seo, Seungyeon Yoo, Nam‐Yun Cho, Yoonjin Kwak, Kyoungbun Lee, Jung Ho Kim, Gyeong Hoon Kang · 2022 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  48. Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer
    Yunchang Li, Lanlin Hu, Xinhao Peng, Huasheng Xu, Bo Tang, Chuan Shan Xu · 2022 · Cancer Drug Resistance
  49. Targeting KRAS : Crossroads of Signaling and Immune Inhibition
    Shumei Kato, Yu Fujiwara, David S. Hong · 2022 · Journal of Immunotherapy and Precision Oncology
  50. Evaluation of immunotherapy efficacy in gynecologic cancer
    Genyi Jiang, Qianhua Wu, Bilan Li · 2023 · Frontiers in Immunology
  51. Colorectal cancer: the immune microenvironment and the gut microbiota – new perspectives, challenges, and opportunities
    Ping Zhou, Wangzheqi Zhang, Yan Liao, Zhiyong Zhai, Sicun Lu, Shuya Jiang, Wei Hu, Wei Gong · 2025 · International Journal of Surgery
  52. Hydroxytyrosol Inhibits MDSCs and Promotes M1 Macrophages in Mice With Orthotopic Pancreatic Tumor
    Botao Wang, Lei Yang, Tianyu Liu, Jing Xun, Yuzhen Zhuo, Lanqiu Zhang, Qi Zhang, Ximo Wang · 2021 · Frontiers in Pharmacology
  53. Large-scale bulk RNA-seq analysis defines immune evasion mechanism related to mast cell in gliomas
    Rui Chen, Wantao Wu, Tao Liu, Yihan Zhao, Yifan Wang, Hao Zhang, Zeyu Wang, Ziyu Dai, Xiaoxi Zhou, Peng Luo et al. · 2022 · Frontiers in Immunology
  54. A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation
    Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, H.‐B. Li, Xingyan Pan, Feng Shu, Kun Zhang et al. · 2025 · Journal of Translational Medicine
  55. Review: KRAS mutations are influential in driving hepatic metastases and predicting outcome in colorectal cancer
    Colin William Steele, Thomas Whittle, Jesse Joshua Smith · 2019 · Chinese Clinical Oncology
  56. Chronic restraint stress promotes the tumorigenic potential of oral squamous cell carcinoma cells by reprogramming fatty acid metabolism via CXCL3 mediated Wnt/β-catenin pathway
    Fangzhi Lou, Huiqing Long, Shihong Luo, Yiyun Liu, Juncai Pu, Haiyang Wang, Ping Ji, Xin Jin · 2022 · Experimental Neurology
  57. Immune microenvironmental heterogeneity according to tumor DNA methylation phenotypes in microsatellite instability-high colorectal cancers
    Jung Ho Kim, Jiyun Hong, Ji Ae Lee, Minsun Jung, Eunwoo Choi, Nam‐Yun Cho, Gyeong Hoon Kang, Sangwoo Kim · 2024 · Cancer Immunology Immunotherapy
  58. Deciphering of intra‐tumoural heterogeneity and the interplay between metastasis‐associated meta‐program and myofibroblasts in gastric cancer
    Xiongyan Wu, Zhijian Jin, Baolong Li, Yifan Lu, Junyi Hou, Lizhong Yao, Zhenjia Yu, Qingqing Sang, Beiqin Yu, Jianfang Li et al. · 2025 · Clinical and Translational Medicine
  59. Oncological transformation in vitro of hepatic progenitor cell lines isolated from adult mice
    Rocío Olivera-Salazar, Mariano García‐Arranz, Aranzazu Sánchez, Susana Olmedillas López, Luz Vega-Clemente, Luis Javier Serrano, Blanca M. Herrera, Damián García‐Olmo · 2022 · Scientific Reports
  60. Targeting Myeloid-Derived Suppressor Cell Trafficking as a Novel Immunotherapeutic Approach in Microsatellite Stable Colorectal Cancer
    Benny Johnson · 2023 · Cancers
  61. Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models
    Lucas A. Horn, Hanne Lind, Kristen Fousek, Haiyan Qin, Nika Rajabian, Shantel M. Angstadt, Nicole Hsiao-Sanchez, Miriam Marlene Medina-Enríquez, Marcus D. Kelly, Clint Tanner Allen et al. · 2024 · Journal of Experimental & Clinical Cancer Research
  62. IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer
    Yanjie Chen, Shu-Neng Luo, Hao Wu, Ning‐Ping Zhang, Ling Dong, Taotao Liu, Li Liang, Xizhong Shen · 2022 · Journal of Translational Medicine
  63. Revealing the contribution of somatic gene mutations to shaping tumor immune microenvironment
    Liwen Xu, Shiwei Zhu, Yujia Lan, Min Yan, Zedong Jiang, Jiali Zhu, Gaoming Liao, Yanyan Ping, Jinyuan Xu, Bo Pang et al. · 2022 · Briefings in Bioinformatics
  64. Costimulatory molecule‐ related lncRNA model as a potential prognostic biomarker in non‐small cell lung cancer
    Yuanshan Yao, Fuzhi Yang, Anna M. Chen, Qingwang Hua, Wen Gao · 2022 · Cancer Medicine
  65. Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer
    Yupeng Jiang, Yuyao Liu, Hong Huang, Tiantian Zhao, Zengyi Zhao, Yawen Gao · 2025 · Cancer Immunology Immunotherapy
  66. KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner
    Pierre-Antoine Laurent, Marina Milić, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Lévy, Michele Mondini et al. · 2023 · Journal of Translational Medicine
  67. Unraveling epigenomic signatures and effectiveness of electroconvulsive therapy in treatment-resistant depression patients: a prospective longitudinal study
    Rosana Carvalho Silva, Paolo G. V. Martini, Christa Hohoff, Stefania Mattevi, Marco Bortolomasi, Maria Abate, Valentina Menesello, Massimo Gennarelli, Bernhard Theodor Baune, Alessandra Minelli · 2024 · Clinical Epigenetics
  68. Balancing Tumor Immunotherapy and Immune-Related Adverse Events: Unveiling the Key Regulators
    Jianshang Huang, Lei Xiong, Sainan Tang, Junhao Zhao, Li Zuo · 2024 · International Journal of Molecular Sciences
  69. Recent Progress and Potential of G4 Ligands in Cancer Immunotherapy
    Jiahui Lin, Zhu Gong, Yen‐Shen Lu, Jiongheng Cai, Junjie Zhang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuobin Chen · 2025 · Molecules
  70. Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment
    Hrvoje Mišetić, Mohamed Reda Keddar, Jean‐Pierre Jeannon, Francesca D. Ciccarelli · 2023 · Genome Medicine
  71. Immune-active tumor-adjacent tissues are associated with favorable prognosis in stage I lung squamous cell carcinoma
    Lisha Ying, Chunliu Zhang, Alexandre Reuben, Yiping Tian, Jiaoyue Jin, Canming Wang, Jing Bai, Xinyuan Liu, Jianfei Fang, Tingting Feng et al. · 2023 · iScience
  72. Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies
    Kang Wang, Yun Wang, Kai Yin · 2024 · Journal of Cancer Research and Clinical Oncology
  73. Immunotherapy in Colorectal Cancer — Finding the Achilles’ Heel
    Robin Park, Anwaar Saeed · 2024 · NEJM Evidence
  74. Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Drivers in Serrated Pathway-Driven Colorectal Cancer Progression
    Jiahui Wang, Yu Long Zhang, Xinyi Chen, Qi Sheng, Junluo Yang, Yuyao Zhu, Yuhang Wang, Fangrong Yan, Jingya Fang · 2024 · International Journal of Molecular Sciences
  75. Drugging the Undruggable and beyond: Emerging precision oncology approaches to target acquired resistance to KRAS G12C and KRAS G12D inhibitors
    Ramesh R. Kale, Charudatt Samant, Krishnadas Nandakumar, Karkala Sreedhara Ranganath Pai, Mandar Bhonde · 2025 · Biochemical and Biophysical Research Communications
  76. Precision immune regulation in KRAS-mutated cancers: the final piece of the puzzle?
    Shenao Fu, Jiayao Ma, Changjing Cai, Jun Tan, Xiangying Deng, Hong Shen, Shan Zeng, Yihong Chen, Ying Han · 2025 · Journal of Experimental & Clinical Cancer Research
  77. Prognostic and Immunotherapeutic Roles of KRAS in Pan-Cancer
    Kaixin Yang, Chengyun Li, Yang Liu, Xueyan Gu, Longchang Jiang, Lei Shi · 2022 · Cells
  78. Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone
    Mengke Fan, Guochuan Zhang, Mingfang Xie, Xinbo Liu, Qi Zhang, Ling Wang · 2022 · Current Oncology
  79. Comprehensive Assessment of Secreted Immuno-Modulatory Cytokines by Serum-Differentiated and Stem-like Glioblastoma Cells Reveals Distinct Differences between Glioblastoma Phenotypes
    Laverne D. Robilliard, Jane J. Yu, Akshata Anchan, Graeme J. Finlay, Catherine Elizabeth Angel, E. Scott Graham · 2022 · International Journal of Molecular Sciences
  80. Regularized survival learning and cross-database analysis enabled identification of colorectal cancer prognosis-related immune genes
    Dongmei Ai, Mingmei Wang, Qingchuan Zhang, Longwei Cheng, Yishu Wang, Xiuqin Liu, Li C. Xia · 2023 · Frontiers in Genetics
  81. Cholangiocarcinoma Risk Factors Open the Floodgates for Gut Microbes and Immunosuppressive Myeloid Cells
    Sharmeen Chagani, Lawrence N. Kwong · 2021 · Cancer Discovery
  82. Unveiling the dual role of circulating tumor cells in colorectal cancer immunotherapy: a comprehensive review of biomarker utility and immune microenvironment crosstalk
    Yifan Feng, Gang Liu, Qixue Cai, Jianping Zhou · 2025 · Frontiers in Immunology
  83. Intratumoral microbiota and host genotype cooperatively shape neutrophil cytotoxic functions in colorectal cancer
    Elisa Sorrenti, Valeria Governa, Davide Bressan, Eleonora Cremonesi, Nicolò Formaggio, Irene Latino, Bianca Calì, Cristina Torcasio, Camilla Basso, Jacopo Galafassi et al. · 2026 · Cell Host & Microbe
  84. Tumor heterogeneity: development, mechanisms, and therapeutic implications
    Jianhong Zhang, Heng Li, Shuo Ru, Hui Feng, Guo J, Danlei Sun, Tingxiu Xiang, Daqian Xu, Yang Luo · 2026 · Signal Transduction and Targeted Therapy
  85. Genetic alterations shape innate immune cells to foster immunosuppression and cancer immunotherapy resistance
    Louis Boafo Kwantwi · 2023 · Clinical and Experimental Medicine
  86. Patterns of immune infiltration in lung adenocarcinoma revealed a prognosis-associated microRNA–mast cells network
    Chunlin Wang, Xi Tang, Jiaojian Wang, Yanhua Xu · 2019 · Human Cell
  87. The Crosstalk Between Malignant Cells and Tumor-Promoting Immune Cells Relevant to Immunotherapy in Pancreatic Ductal Adenocarcinoma
    Xuefei Liu, Ziwei Luo, Xuechen Ren, Zhihang Chen, Xiaoqiong Bao, Jianghua Zheng, Zhixiang Zuo · 2022 · Frontiers in Cell and Developmental Biology
  88. Integrin-Linked Kinase Expression Characterizes the Immunosuppressive Tumor Microenvironment in Colorectal Cancer and Regulates PD-L1 Expression and Immune Cell Cytotoxicity
    Saleh Almasabi, Richard L. Boyd, Afsar U. Ahmed, Bryan R.G. Williams · 2022 · Frontiers in Oncology
  89. MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
    Dario Zimmerli, Chiara Svetlana Brambillasca, Francien Talens, Jinhyuk Bhin, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Max D. Wellenstein, Kelly Kersten, Mart de Boo et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  90. Impact and potential value of immunosenescence on solid gastrointestinal tumors
    Tianshuai Zhang, Rongbo Wen, Hao Fan, Yue Yu, Hang Jia, Zhiying Peng, Leqi Zhou, Guanyu Yu, Wei Zhang · 2024 · Frontiers in Immunology
  91. Roles of clinical application of lenvatinib and its resistance mechanism in advanced hepatocellular carcinoma (Review)
    Ganghui Ye · 2024 · American Journal of Cancer Research
  92. A comprehensive review of mechanisms underlying resistance to immune checkpoint inhibitors
    Alexandre Bertucci, Dr Taleb Khaoula -, Emilien Billon, Téo Fernez, Philippe Rochigneux · 2026 · Frontiers in Immunology
  93. Decoding Immunotherapy Response in Colorectal Cancer: Translational Insights Beyond MSI
    Chiara Cataldi, Beliz Bahar Karaoğlan, Elena Liotta, Sara De Dosso · 2026 · Cancers
  94. Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation
    Paige E. Solomon, Lisa L. Kirkemo, Gary M. Wilson, Kevin Leung, Mark H. Almond, Leanne C. Sayles, Alejandro Sweet-Cordero, Oren S. Rosenberg, Joshua J. Coon, James A. Wells · 2022 · Molecular & Cellular Proteomics
  95. The use of SP/Neurokinin-1 as a Therapeutic Target in Colon and Rectal Cancer
    Desirée Martín‐García, Teresa Téllez, Maximino Redondo, Marilina García‐Aranda · 2023 · Current Medicinal Chemistry
  96. KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down‐regulating SERTAD4
    Yizhen Chen, Yuanyuan Zheng, Shaolin Liu · 2024 · Journal of Cellular and Molecular Medicine
  97. Krill Oil Perturbs Proliferation and Migration of Mouse Colon Cancer Cells in vitro by Impeding Extracellular Signal‐Regulated Protein Kinase Signaling Pathway
    Weiqiang Jing, Yuxuan Bi, Ganyu Wang, Shuyan Zeng, Lihui Han, Hui Yang, Na Wang, Yunxue Zhao · 2020 · Lipids
  98. Remarkable Response of EGFR- and HER2-Amplified Metastatic Colon Cancer to Pyrotinib After Failed Multiline Treatments: A Case Report and Literature Review
    Hong‐Shuai Li, Lili Yang, Mingyi Zhang, Ke Cheng, Ye Chen, Jiyan Liu · 2020 · Frontiers in Oncology
  99. Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer
    Abolarinwa Bilikis Aderonke, Ridwan Babatunde Ibrahim, Yen‐Hua Huang · 2019 · International Journal of Molecular Sciences
  100. lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression
    Xuemei Tang, Haoyu Ruan, Liu Dong, Sihan Li, Zhiyuan Wu, Ming Guan · 2021 · Gastroenterology Research and Practice