Inhibit versus Destroy: Are PROTAC Degraders the Solution to Targeting STAT3?
Open accessAbstract
Despite the role of STAT3 as a known driver of oncogenesis, efforts to develop therapeutic STAT3 inhibitors have thus far been unsuccessful. In this issue of Cancer Cell, Bai et al. report a potent and selective STAT3 degrader capable of producing complete and long-lasting tumor regression in mouse xenograft models.
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References 10 · Cited by 23
- Authors
- Heppler, L. N., & Frank, D. A.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Frank, David A.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 36
- Issue
- 5
- Pages
- 459-461
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2988338102
- Cited by
- 23
- References
- 10
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 3 · 2019: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gilead Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- PROTAC degraders, STAT3, protein degradation, STAT3 inhibitor, carcinogenesis, tumor regression, xenograft mouse model, targeted cancer therapy
- MeSH terms
- Animals, Humans, Neoplasms, Cell Line, Tumor, STAT3 Transcription Factor, Mice, Proteolysis
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