The NCI-MATCH: A National, Collaborative Precision Oncology Trial for Diverse Tumor Histologies
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The NCI-MATCH is a national master protocol trial, published in the Journal of Clinical Oncology, in which diverse tumors are sequenced and patients assigned to treatment. The trial demonstrates the feasibility of identifying rare and common actionable genetic alterations and underscores the strength of academic/community partnerships for improving trial access.
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Organoids are ideally suited for functional precision medicine due to their ease of establishment, similarity with the tissue of origin, and tractability.
“Organoids are ideally suited for FPM due to their ease of establishment, similarity with the tissue of origin and tractability158,167 and have been deployed to identify therapeutic leads in a number of tumors168, including rare cancers that tend to be understudied and poorly characterized at the molecular level16,151,169,170.”
From Organoids (2022) · cites this paper as [167]
The supplied passages describe NCI-MATCH’s sequencing and biomarker-selected treatment arms, not organoids. Searches for organoids and functional precision medicine found no passage addressing ease of establishment, similarity to tissue of origin, or tractability (section labeled Abstract; page unavailable). (LLM, conf=0.75)
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References 11 · Cited by 33
- Authors
- Murciano-Goroff, Y. R., Drilon, A., & Stadler, Z. K.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Stadler, Zsofia K.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 39
- Issue
- 1
- Pages
- 22-24
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC10640715
- OpenAlex
- W3120726054
- Cited by
- 33
- References
- 11
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 10 · 2022: 3 · 2021: 6
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Keywords
- NCI-MATCH, precision oncology, tumor genomic profiling, actionable genomic alterations, university-community collaboration
- MeSH terms
- Clinical Trials as Topic, Feasibility Studies, Humans, Mutation, Neoplasms, Time Factors, Sequence Analysis, DNA, Sample Size, Interdisciplinary Communication, Rare Diseases, Precision Medicine, Molecular Targeted Therapy
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