The Role of Aldosteronism in Causing Obesity-Related Cardiovascular Risk
Open accessAbstract
A large body of evidence strongly links aldosterone to development and progression of cardiovascular disease, including vascular stiffness, left ventricular hypertrophy, congestive heart failure, chronic kidney disease, and, especially, hypertension. Emerging data suggest that adipocytes may serve as a source of aldosterone, either directly or indirectly, through the release of aldosterone-stimulating factors. If adipocytes are confirmed to have an important contribution to hyperaldosteronism, it would have significant clinical implications in linking aldosterone to obesity-related increases in cardiovascular risk. Such a cause-and-effect situation would then provide the opportunity to reverse that risk with preferential use of aldosterone antagonists in obese patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Heightened mineralocorticoid activity is important in resistant hypertension.
“Mounting evidence further supports the importance of heightened mineralocorticoid activity in RH.149–151”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [151]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 63 · Cited by 74
Research works printed but not linked: 2
- [43]El-Gharbawy AH Nadig VS Kotchen JM Arterial pressure, left ventricular mass, and aldosterone in essential hypertension Hypertension 2001 37 845 850 11244006
- [58]Dall'Asta C Vedani P Manunta P Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity Nutr Metab Cardiovasc Dis 2009 19 110 114 18718746
- Authors
- Calhoun, D. A., & Sharma, K.
- Affiliations
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Corresponding author
- Calhoun, David A.
- Venue
- Cardiology Clinics
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 28
- Issue
- 3
- Pages
- 517-527
- ISSN
- 0733-8651 (ISSN-L)
- PMC
- PMC2904339
- OpenAlex
- W2136047948
- Cited by
- 74
- References
- 63
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 6 · 2013: 9 · 2012: 3
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cardiology Clinics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK053867)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- hyperaldosteronism, obesity, cardiovascular risk, adipocytes, aldosterone, mineralocorticoid receptor antagonists, hypertension, left ventricular hypertrophy, vascular stiffness, congestive heart failure, chronic kidney disease
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Hyperaldosteronism, Hypertension, Obesity, Risk Factors, Adipocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
