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Coronary Artery Disease and Diabetes Mellitus
Open accessAbstract
Diabetes mellitus (DM) is a major risk factor for cardiovascular disease. Near-normal glycemic control does not reduce cardiovascular events. For many patients with 1- or 2-vessel coronary artery disease, there is little benefit from any revascularization procedure over optimal medical therapy. For multivessel coronary disease, randomized trials demonstrated the superiority of coronary artery bypass grafting over multivessel percutaneous coronary intervention in patients with treated DM. However, selection of the optimal myocardial revascularization strategy requires a multidisciplinary team approach ('heart team'). This review summarizes the current evidence regarding the effectiveness of various medical therapies and revascularization strategies in patients with DM.
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“Dysfunction of multiple organ systems manifests similarly in diabetes as it does during normal chronological ageing, but in diabetes this frequently occurs at a younger age [2–4].”
From Cellular senescence: at the nexus between ageing and diabetes (2019) · cites this paper as [2]
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Metadata
- Authors
- Aronson, D., & Edelman, E. R.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Brigham and Women's Hospital (US)
- Venue
- Cardiology Clinics
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 32
- Issue
- 3
- Pages
- 439-455
- ISSN
- 0733-8651 (ISSN-L)
- PMC
- PMC4672945
- OpenAlex
- W2103962300
- Cited by
- 222
- References
- 125
- Citations by year
- 2026: 9 · 2025: 30 · 2024: 24 · 2023: 27 · 2022: 29 · 2021: 27 · 2020: 23 · 2019: 19 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cardiology Clinics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM049039)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- coronary artery disease, diabetes mellitus, glycemic control, cardiovascular risk, coronary revascularization, coronary artery bypass grafting, percutaneous coronary intervention, multivessel coronary artery disease, heart team, optimal medical therapy
- MeSH terms
- Coronary Artery Disease, Diabetes Mellitus, Humans, Hypoglycemic Agents, Myocardial Revascularization, Risk Factors, Global Health, Incidence, Prevalence, Glycemic Index
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