MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors

Huntly, Brian J.P.; Shigematsu, Hirokazu; Deguchi, Kenji; Lee, Benjamin H.; Mizuno, Shinichi; Duclos, Nicky; Rowan, Rebecca; Amaral, Sonia; Curley, David; Williams, Ifor R.; Akashi, Koichi; Gilliland, D.Gary

doi:10.1016/j.ccr.2004.10.015

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors

To better understand the origin of leukemic stem cells, we tested the hypothesis that all leukemia oncogenes could transform committed myeloid progenitor cells lacking the capacity for self-renewal, as has recently been reported for MLL-ENL. Flow-sorted populations of common myeloid progenitors a…