The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
Open accessAbstract
Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation. To investigate the role of BCL6 in DLBCL pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL. These mice display increased GC formation and perturbed post-GC differentiation characterized by a decreased number of post-isotype switch plasma cells. Subsequently, these mice develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBCL. These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease.
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“In genetically engineered mice, overexpression of BCL6 is sufficient to drive lymphoma development17.”
From Small-molecule-induced polymerization triggers degradation of BCL6 (2020) · cites this paper as [17]
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Cites
Cancer: Principles and Practice of Oncology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-819_4 · Cited by 8,524
Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475
Cancer: Principles and Practice of Oncology.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-506_5 · Cited by 1,913
Clonal selection and learning in the antibody system
Rajewsky, K. (1996) · Nature · doi:10.1038/381751a0 · Cited by 1,701
Shaffer, A. L., Lin, K., Kuo, T. C., Yu, X., Hurt, E. M., Rosenwald, A., Giltnane, J. M., Yang, L., Zhao, H., Calame, K. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00335-7 · Cited by 1,048
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
Dent, A. L., Shaffer, A. L., Yu, X., Allman, D., & Staudt, L. M. (1997) · Science · doi:10.1126/science.276.5312.589 · Cited by 950
Shaffer, A. L., Yu, X., He, Y., Boldrick, J. C., Chan, E. P., & Staudt, L. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00020-0 · Cited by 879
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
Ye, B. H., Cattoretti, G., Shen, Q. “., Zhang, J., Hawe, N., de Waard, R., Leung, C. C., Nouri-Shirazi, M. A., Orazi, A., Chaganti, R. S. K., et al. (1997) · Nature Genetics · doi:10.1038/ng0697-161 · Cited by 820
Self-citationCellular Origin of Human B-Cell Lymphomas
Küppers, R., Klein, U., Hansmann, M., & Rajewsky, K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911113412007 · Cited by 715
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
Phan, R. T., & Dalla‐Favera, R. (2004) · Nature · doi:10.1038/nature03147 · Cited by 705
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The generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3795 · Cited by 1,565
Germinal centres: role in B-cell physiology and malignancy
Klein, U., & Dalla‐Favera, R. (2007) · Nature reviews. Immunology · doi:10.1038/nri2217 · Cited by 899
Self-citationBéguelin, W., Popovic, R., Teater, M. R., Jiang, Y., Bunting, K. L., Rosen, M., Shen, H., Yang, S. N., Wang, L., Ezponda, T., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.04.011 · Cited by 897
Aukema, S., Siebert, R., Schuuring, E. M. D., Imhoff, G. W. V., Kluin‐Nelemans, H. C., Boerma, E.-J. G., & Kluin, P. M. (2010) · Blood · doi:10.1182/blood-2010-09-297879 · Cited by 677
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
Crotty, S., Johnston, R. J., & Schoenberger, S. P. (2010) · Nature Immunology · doi:10.1038/ni.1837 · Cited by 541
Metadata
- Authors
- Cattoretti, G., Pasqualucci, L., Ballon, G., Tam, W., Nandula, S. V., Shen, Q., Mo, T., Murty, V. V., & Dalla-Favera, R.
- Affiliations
- Columbia University (US)
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 7
- Issue
- 5
- Pages
- 445-455
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2091213817
- Cited by
- 383
- References
- 48
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 15 · 2023: 24 · 2022: 15 · 2021: 23 · 2020: 19 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 22 · 2015: 17 · 2014: 15 · 2013: 17 · 2012: 23
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Cancer Institute (P01CA092625, CA092625)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- BCL6, diffuse large B-cell lymphoma, germinal center, chromosomal translocation, class switch recombination, plasma cells, lymphoproliferative disorders, B-cell lymphomagenesis
- MeSH terms
- Animals, Cell Differentiation, Chromosome Aberrations, Disease Models, Animal, DNA-Binding Proteins, Genes, Immunoglobulin, Hemagglutinins, Humans, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Transgenic, Plasma Cells, Promoter Regions, Genetic, Spleen, Splenomegaly, Time Factors, Gene Expression, Survival Analysis, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Mice, Knockout, Germinal Center, Mice, Proto-Oncogene Proteins c-bcl-6
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