The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
What has senescence got to do with cancer?
Open accessAbstract
Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative capacity of cells, thus preventing the proliferation of cells that are at different stages of malignancy. A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy.
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Citations
Cites
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Self-citationSpecific Association of Human Telomerase Activity with Immortal Cells and Cancer
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“More than 90% of tumors contain readily detectable telo merase activity (Kim et al., 1994).”
BackgroundTelomeres shorten during ageing of human fibroblasts
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“Indeed, activated HRAS (V12) was found to induce premature senescence in pri mary rodent and human cells (Serrano et al., 1997).”
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BackgroundCreation of human tumour cells with defined genetic elements
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“SAHF are present only in human fibroblasts that contain high p16 during senescence, suggesting that p16 plays a role in generating SAHF.”
BackgroundInfluential
Cited by
Cellular senescence: when bad things happen to good cells
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“Some of these genes permanently arrest the growth of cells at risk for neoplastic transformation, a process termed cellular senescence [4–6].”
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Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604
Metadata
- Authors
- Dimri, G. P.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 7
- Issue
- 6
- Pages
- 505-512
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2030963645
- Cited by
- 313
- References
- 40
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
