PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells.
Open accessAbstract
Improved understanding of the molecular pathways that suppress the genesis and maintenance of cancer stem cells will facilitate development of rationally targeted therapies. PU.1 is a transcription factor that is required for normal myelomonocytic differentiation in hematopoiesis, and reduced PU.1 activity has been associated with myeloid leukemogenesis in man and in mouse models. A recent study by Steidl et al. demonstrates that Junb and Jun, two AP-1 transcription factors, are critical downstream effectors of the tumor suppressor activity of PU.1, and that reduced expression of Junb, in particular, may be a common feature of acute myeloid leukemogenesis.
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In several cell types PU.1 can function as a tumor suppressor.
“In several cell types PU.1 can function as a tumor suppressor [25], [26].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [25]
The Abstract (page not provided) describes PU.1 as a tumor suppressor and later identifies PU.1 and JUNB as myeloid-lineage tumor suppressors. It does not establish tumor-suppressor activity in several cell types; its discussion is confined to myeloid leukemogenesis. (LLM, conf=0.83)
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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
Krivtsov, A. V., Twomey, D., Feng, Z., Stubbs, M. C., Wang, Y., Faber, J., Levine, J. E., Wang, J., Hahn, W. C., Gilliland, D. G., et al. (2006) · Nature · doi:10.1038/nature04980 · Cited by 1,513 · see citing works
Mueller, B. U., Pabst, T., Fos, J., Petkovic, V., Fey, M. F., Asou, N., Buergi, U., & Tenen, D. G. (2006) · Blood · doi:10.1182/blood-2005-07-3068 · Cited by 207 · see citing works
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IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation
Park, S.-M., Cho, H., Thornton, A. M., Barlowe, T. S., Chou, T., Chhangawala, S., Fairchild, L., Taggart, J., Chow, A., Schurer, A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.016 · Cited by 97 · see citing works
The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis
Jabeen, R., Chang, H.-C., Goswami, R., Nutt, S. L., & Kaplan, M. H. (2011) · PLOS ONE · doi:10.1371/journal.pone.0022189 · Cited by 10 · see citing works
- Authors
- Somervaille, T. C. P., & Cleary, M. L.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Cleary, Michael L.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 10
- Issue
- 6
- Pages
- 456-457
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2056656653
- Cited by
- 25
- References
- 2
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2012: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- PU.1, JunB, c-Jun, acute myeloid leukemia, leukemia stem cells, cancer stem cells, AP-1 transcription factor, tumor suppressor activity, myelomonocytic differentiation, hematopoiesis, leukemogenesis
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Humans, Proto-Oncogene Proteins, Neoplastic Stem Cells, Leukemia, Myeloid, Acute, Trans-Activators, Proto-Oncogene Proteins c-jun, Tumor Suppressor Proteins, Mice
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