The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin
Open accessAbstract
Synovial sarcoma is an aggressive soft-tissue malignancy marked by a unique t(X;18) translocation leading to expression of a chimeric SYT-SSX fusion protein. We report here a mouse model of synovial sarcoma based on conditional expression of the human SYT-SSX2. Using this model, we have identified myoblasts as a potential source of synovial sarcoma. Remarkably, within the skeletal muscle lineage, while expression of the oncoprotein in immature myoblasts leads to induction of synovial sarcoma with 100% penetrance, its expression in more differentiated cells induces myopathy without tumor induction. We also show that early widespread expression of the fusion protein disrupts normal embryogenesis, causing lethality.
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Generalized lacZ expression with the ROSA26 Cre reporter strain
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
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Enzinger and Weiss's Soft Tissue Tumors
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SYT–SSX Gene Fusion as a Determinant of Morphology and Prognosis in Synovial Sarcoma
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Myogenic Regulatory Factors and the Specification of Muscle Progenitors in Vertebrate Embryos
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Molecular characterisation of soft tissue tumours: a gene expression study
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Cited by
Walkley, C. R., Qudsi, R., Sankaran, V. G., Perry, J. A., Gostissa, M., Roth, S. I., Rodda, S. J., Snay, E., Dunning, P., Fahey, F. H., et al. (2008) · Genes & Development · doi:10.1101/gad.1656808 · Cited by 373
Günther, S., Kim, J., Kostin, S., Lepper, C., Fan, C.-M., & Braun, T. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.07.016 · Cited by 280
Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing
Laks, E., McPherson, A., Zahn, H., Lai, D., Steif, A., Brimhall, J., Biele, J., Wang, B., Masud, T., Ting, J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.026 · Cited by 257
Devalaraja, S., To, T. K. J., Folkert, I. W., Natesan, R., Alam, M. Z., Li, M., Tada, Y., Budagyan, K., Dang, M. T., Zhai, L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.042 · Cited by 257
Self-citationCells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
Mutsaers, A. J., & Walkley, C. R. (2014) · Bone · doi:10.1016/j.bone.2014.02.003 · Cited by 233
Metadata
- Authors
- Haldar, M., Hancock, J. D., Coffin, C. M., Lessnick, S. L., & Capecchi, M. R.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 11
- Issue
- 4
- Pages
- 375-388
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2108740070
- Cited by
- 326
- References
- 35
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Haldar, M., Hancock, J. D., Coffin, C. M., Lessnick, S. L., & Capecchi, M. R. (2007). A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin. Cancer Cell. https://doi.org/10.1016/j.ccr.2007.01.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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