The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53
Open accessAbstract
Summary Cancer cells neutralize p53 by deletion, mutation, proteasomal degradation, or sequestration to achieve a pathologic survival advantage. Targeting the E3 ubiquitin ligase HDM2 can lead to a therapeutic surge in p53 levels. However, the efficacy of HDM2 inhibition can be compromised by overexpression of HDMX, an HDM2 homologue that binds and sequesters p53. Here we report that a stapled p53 helix preferentially targets HDMX, blocks the formation of inhibitory p53-HDMX complexes, induces p53-dependent transcriptional upregulation, and thereby overcomes HDMX-mediated cancer resistance in vitro and in vivo. Importantly, our analysis of p53 interaction dynamics provides a blueprint for reactivating the p53 pathway in cancer by matching HDM2, HDMX, or dual inhibitors to the appropriate cellular context.
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Cites
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Cited by
MDM2, MDMX and p53 in oncogenesis and cancer therapy
Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279
Self-citationSmall-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality
Arkin, M. R., Tang, Y., & Wells, J. A. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.001 · Cited by 1,065
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
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Modulators of Protein–Protein Interactions
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Stapled Peptides for Intracellular Drug Targets
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Metadata
- Authors
- Bernal, F., Wade, M., Godes, M., Davis, T. N., Whitehead, D. G., Kung, A. L., Wahl, G. M., & Walensky, L. D.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 18
- Issue
- 5
- Pages
- 411-422
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2171033030
- Cited by
- 285
- References
- 33
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bernal, F., Wade, M., Godes, M., Davis, T. N., Whitehead, D. G., Kung, A. L., Wahl, G. M., & Walensky, L. D. (2010). A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53. Cancer Cell. https://doi.org/10.1016/j.ccr.2010.10.024
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