The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
Open accessAbstract
Summary The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in an MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K79me2, H3K4me3, H3K27me3 and H3K36me3 in hematopoietic progenitor and leukemia stem cells (LSC). We found abnormal profiles only for H3K79me2 on MLL-AF9 fusion target loci in LSC. Inactivation of Dot1l lead to down-regulation of direct MLL-AF9 targets and an MLL-translocation associated gene expression signature, while global gene expression remained largely unaffected. Suppression of MLL-translocation associated gene expression corresponded with dependence of MLL-AF9 leukemia on Dot1l in vivo. These data point to DOT1L as a potential therapeutic target in MLL-rearranged leukemia.
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Cites
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InfluentialSelf-citationGenome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
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Metadata
- Authors
- Bernt, K. M., Zhu, N., Sinha, A. U., Vempati, S., Faber, J., Krivtsov, A. V., Feng, Z., Punt, N., Daigle, A., Bullinger, L., Pollock, R. M., Richon, V. M., Kung, A. L., & Armstrong, S. A.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 20
- Issue
- 1
- Pages
- 66-78
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2069918359
- Cited by
- 870
- References
- 47
- FWCI
- 36.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bernt, K. M., Zhu, N., Sinha, A. U., Vempati, S., Faber, J., Krivtsov, A. V., Feng, Z., Punt, N., Daigle, A., Bullinger, L., Pollock, R. M., Richon, V. M., Kung, A. L., & Armstrong, S. A. (2011). MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.06.010
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