The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

Cited by (153)

Items 101–153 of 153

1. Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway
   Meghan R. Porter, Akiko Kochi, Jonathan A. Karty, Mi Hee Lim, Jeffrey M. Zaleski · 2014 · Chemical Science
2. New amyloid beta-disaggregating agents: synthesis, pharmacological evaluation, crystal structure and molecular docking of N -(4-((7-chloroquinolin-4-yl)oxy)-3-ethoxybenzyl)amines
   Tarana Umar, Shruti Shalini, Md Kausar Raza, Siddharth Gusain, Jitendra Kumar, Waqar Ahmed, Manisha Tiwari, Nasimul Hoda · 2018 · MedChemComm
3. Effects of Multifunctional Antioxidants on Mitochondrial Dysfunction and Amyloid-β Metal Dyshomeostasis
   Hiroyoshi Kawada, Karen Blessing, Tomomi Kiyota, Theodor A Woolman, Lee C. Winchester, Peter F. Kador · 2015 · Journal of Alzheimer s Disease
4. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease
   Michael W. Beck, Jeffrey S. Derrick, Jong‐Min Suh, Mingeun Kim, Kyle J. Korshavn, Richard A. Kerr, Woo Jong Cho, Scott D. Larsen, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy et al. · 2017 · ChemMedChem
5. Fluorescent Copper Probe Inhibiting Aβ1–16-Copper(II)-Catalyzed Intracellular Reactive Oxygen Species Production
   Gulshan R. Walke, Dnyanesh S. Ranade, Suman Ramteke, Srikanth Rapole, Cristina Satriano, Enrico Rizzarelli, Gaetano Andrea Tomaselli, Giuseppe Trusso Sfrazzetto, Prasad Padmakar Kulkarni · 2017 · Inorganic Chemistry
6. Discovery of Guanidine Derivatives from Buthus martensii Karsch with Metal-Binding and Cholinesterase Inhibition Properties
   Yu‐Ming Liu, Jingjing Fan, Li‐Ning Wang · 2021 · Molecules
7. Computational Design of Copper Ligands with Controlled Metal Chelating, Pharmacokinetics, and Redox Properties for Alzheimer’s Disease
   Diego Chaparro, Areli Flores‐Gaspar, Jorge Alí‐Torres · 2020 · Journal of Alzheimer s Disease
8. Calprotectin influences the aggregation of metal-free and metal-bound amyloid-β by direct interaction
   Hyuck Jin Lee, Masha G. Savelieff, Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Shin Jung C. Lee, Elizabeth M. Nolan, Mi Hee Lim · 2018 · Metallomics
9. Targeted Colon Cancer and Chemotherapeutic Through Metal Glycoconjugates: Design, Synthesis, Molecular Docking, and DFT Investigations
   Waad A. Al‐Otaibi, Sahar M. AlMotwaa, Amrajaa S. Abubakr, Safaa S. Hassan, Fatma B. Rashidi · 2025 · Applied Organometallic Chemistry
10. Monitoring of intermediates of clioquinol electro-oxidation by thin-layer spectral and electrophoretic electrochemistry
    Wenwen Zhang, Xiao‐Lin He, Ning Deng, Yan Wang, Jianbo He · 2014 · Electrochimica Acta
11. The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013
    Leonid I. Belen’kii, Yu. B. Evdokimenkova · 2015 · Advances in heterocyclic chemistry
12. Chelating Agents as Tools for the Treatment of Metal Overload
    Elżbieta Gumienna‐Kontecka, Valeria Marina Nurchi, Agnieszka Szebesczyk, Paulina Bilska, Karolina Krzywoszyńska, Henryk Kozłowski · 2013 · Zeitschrift für anorganische und allgemeine Chemie
13. Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation
    Valeria Lanza, Roberta D’Agata, Giuseppe Iacono, Francesco Bellia, Giuseppe Spoto, Graziella Vecchio · 2015 · Journal of Inorganic Biochemistry
14. Beyond chemotherapy: Spatiotemporal activation of metal complexes for deep-tissues precision medicine
    Yida Pang, Fang Zhao, Yuting Wang, Qiao Song, Qian Wang, Junrong Li, Ruiping Zhang, Yao Sun · 2025 · Coordination Chemistry Reviews
15. Benzothiazole-Isatin Hybrids: Synthesis, Characterization, Computational and Cytotoxic Activity Studies
    P. V. Navaneethgowda, Yadav D. Bodke, B Manjunatha, K.M. Mussuvir Pasha · 2022 · Journal of Molecular Structure
16. Cyclen-based chelators for the inhibition of Aβ aggregation: Synthesis, anti-oxidant and aggregation evaluation
    Mahmoud El Safadi, Mohan Madhav Bhadbhade, Ronald Shimmon, Anthony Thomas Baker, Andrew M. McDonagh · 2017 · Inorganica Chimica Acta
17. A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress
    Andrew T. Franks, Qin Wang, Katherine J. Franz · 2015 · Bioorganic & Medicinal Chemistry Letters
18. N-Acetyl-5-arylidenetetramic acids: synthesis, X-ray structure elucidation and application to the preparation of zinc(II) and copper(II) complexes
    Dimitris Matiadis, Olga Igglessi‐Markopoulou, Vickie McKee, John Markopoulos · 2014 · Tetrahedron
19. Evaluation of Anti‐Alzheimer's Potential of Azo‐Stilbene‐Thioflavin‐T derived Multifunctional Molecules: Synthesis, Metal and Aβ Species Binding and Cholinesterase Activity
    Monika Rana, Karna Terpstra, C. G. GUTIERREZ, Kerui Xu, Hemant Arya, Tarun Kumar Bhatt, Liviu M. Mirica, Anuj K. Sharma · 2024 · Chemistry - A European Journal
20. Methylenediphosphonotetrathioate: Synthesis, Characterization, and Chemical Properties
    Aviran Amir, Alon Haim Sayer, Alon Ezra, Bilha Fischer · 2013 · Inorganic Chemistry
21. Conjugates of desferrioxamine and aromatic amines improve markers of iron-dependent neurotoxicity
    Rodrigo Rodrigues Victor de Carvalho, Tanara Vieira Peres, Cleber Wanderlei Liria, M. Teresa Machini, Michael Aschner, Breno Pannia Espósito · 2021 · BioMetals
22. Ligand Design to Target and Modulate Metal–Protein Interactions in Neurodegenerative Diseases
    Michael W. Beck, Amit S. Pithadia, Alaina S. DeToma, Kyle J. Korshavn, Mi Hee Lim · 2014 · Wiley eBooks
23. Multi‐Targeting Tacrine Conjugates with Cholinesterase and Amyloid‐Beta Inhibitory Activities: New Anti‐Alzheimer's Agents
    Asha Hiremathad, Sı́lvia Chaves, Rangappa Sangappa Keri · 2021 · Chemistry & Biodiversity
24. Bis(8‐hydroxyquinoline) Ligands: Exploring their Potential as Selective Copper‐Binding Agents for Alzheimer's Disease
    Valentina Oliveri, Graziella Vecchio · 2021 · European Journal of Inorganic Chemistry
25. Copper and cuproptosis: mechanisms, biology, and roles in disease
    Fudi Wang, Wenye Liu, Cong Tao, Liyun Chen, Ningjun Ni, Liujing Huang, Yueyang Ouyang, Qianqian Shi, Dandan Wu, Chenghua Li et al. · 2026 · 中国科学通报：英文版
26. Redox reactivities of membrane-bound amyloid-β-Cu complexes and their targeting by metallothionein-3
    Luciano Perez-Medina, Gabriele Meloni · 2025 · Free Radical Biology and Medicine
27. Curcumin Derivatives as Metal-Chelating Agents: Implications for Potential Therapeutic Agents for Neurological Disorders
    Érika Ferrari · 2019 · Elsevier eBooks
28. Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1 H )-one iron chelators in an in vitro cell model of Parkinson's disease
    Frank W. Lewis, Kathleen Bird, Jean-Philippe Navarro, Rawa El Fallah, Jérémy Brandel, Véronique Hubscher‐Bruder, Andrew Tsatsanis, James A. Duce, David Tétard, Samuel Bourne et al. · 2022 · Dalton Transactions
29. Nucleoside-(5′→P) Methylenebisphosphonodithioate Analogues: Synthesis and Chemical Properties
    Diana Meltzer, Yael Nadel, Joanna Lecka, Aviran Amir, Jean Sévigny, Bilha Fischer · 2013 · The Journal of Organic Chemistry
30. 2-Phenylbenzothiazolyl iridium complexes as inhibitors and probes of amyloid β aggregation
    Karna Terpstra, Yiran Huang, Hanah Na, Liang Sun, Citlali Gutierrez, Zhengxin Yu, Liviu M. Mirica · 2024 · Dalton Transactions
31. Investigation on the physicochemical properties of trans -4-stilbenecarboxaldehyde-derived hydrazones and their copper(II) complexes
    Lenka V. Tamayo, Jéferson G. Da Silva, Matheus Campos Quintão, Hélio Anderson Duarte, Sônia R.W. Louro, Heloísa de Oliveira Beraldo · 2017 · Polyhedron
32. Metal Ions and Complexes in A lzheimer's Disease: From Fundamental to Therapeutic Perspectives
    Christelle Hureau · 2018 · Wiley eBooks
33. Computational evidence to design an appropriate candidate for the treatment of Alzheimer's disease through replacement of the heptamethylene linker of bis(7)tacrine with S-allylcysteine
    Mahboobeh Eslami, Seyed Majid Hashemianzadeh, Kiana Gholamjani Moghaddam, Layasadat Khorsandi, Seyed Abolfazl Seyed Sajadi · 2015 · RSC Advances
34. Recent Advances in the Quest for Treatment and Management of Alzheimer and Other Dementia
    Sameena Ejaz Tanwir, Ajay Kumar · 2019 · Open Journal of Medicinal Chemistry
35. New chelating agents for Cu(II), Fe(III), Al(III), and Zn(II) based on β-diketonate-3-substituted phthalide (isobenzofuranone) and isoindolinone
    Luana Di Matteo, Olga Christodoulakis, Rosanna Filosa, Paolo De Caprariis, Antonia Di Mola, Ermanno Vasca, António Massa · 2014 · Journal of Coordination Chemistry
36. The Outliers: Metal-Mediated Radical Reagents for Biological Substrate Degradation
    Meghan R. Porter, Joan M. Walker, Jeffrey M. Zaleski · 2019 · Accounts of Chemical Research
37. Ruthenium Complexes of Phenylbenzothiazole‐Quinoline based Ligands for Selective α‐Olefination of Methylazaarenes
    Surabhi Bhatt, Priyal Malpani, Swati Swornaprava Pati, Nitish Kumar, Nattamai S. P. Bhuvanesh, Hemant Joshi, Anuj K. Sharma · 2024 · European Journal of Inorganic Chemistry
38. Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization
    Matteo Mari, Silvia Belluti, Luca Pampanella, Carol Imbriano, Alfonso Zambon, Jennifer Storchi, Laura Pigani, Marianna Tosato, Sara Rubagotti, Pier Cesare Capponi et al. · 2025 · Journal of Inorganic Biochemistry
39. 8-Hydroxyquinolines: A Promising Pharmacophore Potentially Developed as Disease-Modifying Agents for Neurodegenerative Diseases: A Review
    Veda Prachayasittikul, Ratchanok Pingaew, Supaluk Prachayasittikul, Virapong Prachayasittikul · 2022 · Heterocycles
40. Zinc-porphyrin complex as multifunctional anti-AD agent: Synthesis, X-ray single crystal analysis and activity study
    Xiang Zhou, Lijun Zhang, Jie Zhi, Lihua Zhao, Rui Shen, Aihong Yang, Xiaodi Kou · 2026 · Journal of Inorganic Biochemistry
41. Exploring Flavonoids Rutin and Morin as Multi‐Target–Directed Ligands for Metal Chelation, Amyloid Interaction, and AChE‐Induced Amyloid Inhibition
    Priyal Malpani, Monika Rana, Umesh Morda, Anuj K. Sharma · 2026 · ChemistrySelect
42. An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases
    Frank W. Lewis, David Tétard · 2017 · Elsevier eBooks
43. Quelantes bifuncionais para o tratamento de neurodisfunções associadas ao ferro
    Rodrigo Carvalho · 2019
44. Prion Disease
    Magdalena Rowińska‐Żyrek, Daniela Valensin, Marek Łuczkowski, Henryk Kozłowski · 2013 · Royal Society of Chemistry eBooks
45. Interações de ligantes imínicos com peptídeos amiloides e metais essenciais implicados em processos neurodegenerativos
    Camila Anchau Wegermann · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
46. Selective Reversal of Cu-Amyloid Aggregation Monitored in Real Time by Fluorescence Anisotropy: Ni-Bme-Dach vs EDTA Benchmarks
    Alyssa Schroeder, Eleanor K. Adams, Dane C. Frost, Erica Lopez, Jennie R. Giacomini, Marilyn Rampersad Mackiewicz · 2026 · ACS Omega
47. Nouvelles preuves de concept pour la chélatothérapie contre la maladie d'Alzheimer : études spectroscopiques des interactions entre les ions cuivre et zinc
    Amandine Conte‐Daban · 2017 · theses.fr (ABES)
48. Development of copper ligands for therepeutic applications
    Raúl Balderrama-Martínez-Sotomayor · 2020 · theses.fr (ABES)
49. Synthesis of new bis(triethylphosphine)platinum(II) complexes containing heterocyclic selenones as potential inhibitors of human cancer: Experimental and theoretical investigations
    Adam A. A. Sulaiman, Gaurav Bhatia, Mohammed Fettouhi, Ismail Daoud, Ridha Ben Said, Seyfeddine Rahali, Mariam S. Farghaly, Ard Elshifa. M. E. Mohammed, Muneera Alrasheedi, Anvarhusein Abdulkadir Isab · 2026 · Journal of King Saud University - Science
50. A DFT study on 1,10-phenanthroline stabilized homonuclear and heteronuclear M–M bonds (M = Be–Sr) in alkaline earth metal dimers
    Prasenjit Das, Pratim Kumar Chattaraj · 2026 · Physical Chemistry Chemical Physics
51. Targeting Cu2+ mediated Aβ aggregation and ROS generation using 2-(4-aminophenyl)benzothiazole–based chelators
    Priyal Malpani, Surabhi Bhatt, Aishwarya Mehta, Nattamai S. P. Bhuvanesh, Hemant Joshi, Anuj K. Sharma · 2026 · Inorganica Chimica Acta
52. BindingDB Entry 50001562: Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    BindingDB · 2020 · UC San Diego
53. BindingDB Entry 50002395: Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.
    BindingDB · 2020 · UC San Diego