SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
Letouzé, Eric, Martinelli, Cosimo, Loriot, Céline, Burnichon, Nelly, Abermil, Nasséra, Ottolenghi, Chris, Janin, Maxime, Menara, Mélanie, Nguyen, An Thach, Benit, Paule, Buffet, Alexandre, Marcaillou, Charles, Bertherat, Jérôme, Amar, Laurence, Rustin, Pierre, De Reyniès, Aurélien, Gimenez-Roqueplo, Anne-Paule, Favier, Judith·2013·Cancer Cell
Cited by (813)
Items 601–700 of 813
- Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and ParagangliomasJasmijn B. Miltenburg, Marnix Gorissen, Inge van Outersterp, Iris Versteeg, Alex Nowak, Richard J. Rodenburg, Antonius Eduard van Herwaarden, André J. Olthaar, Benno Küsters, Catleen Conrad et al. · 2024 · International Journal of Molecular Sciences
- A rare case of a 65 year old female with a mesenteric paragangliomaRaffaele Rocco, Brittany L. Murphy, Vatsal P. Patel, Oksana Hamidi, Alice Y. Chang, Melanie L. Lyden · 2019 · Human Pathology Case Reports
- A bittersweet symphonyAdrian Daly, Albert M. Beckers · 2014 · Endocrine Related Cancer
- Acute myeloid leukemia therapy elicits durable complete response in chemoradio‐resistant metastatic paragangliomaSameer Farouk Sait, Rachel Kobos, Michael P. LaQuaglia, Neeta D. Pandit-Taskar, Shakeel I. Modak · 2016 · Pediatric Blood & Cancer
- DNA Methylation Changes in CancerJohn P. Thomson, Richard R. Meehan · 2017 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Misregulation of DNA Methylation Regulators in CancerJoyce J. Thompson, Keith D. Robertson · 2017 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Pathologies liées aux déficits du cycle de KrebsPaule Bénit, Sylvie Bortoli, Dominique Chrétien, Malgorzata Rak, Pierre Rustin · 2018 · Revue Francophone des Laboratoires
- SDHB and SDHA Immunohistochemistry in Canine PheochromocytomasFiras Mohammed Abed, Melissa A. Brown, Omar Ahmed Al-Mahmood, Michael J. Dark · 2020 · Animals
- Pheochromocytoma and ParagangliomaMercedes Robledo, María Currás, Alberto Cascón · 2021 · Springer eBooks
- Lack of Major Genome-Wide DNA Methylation Changes in Succinate-Treated Human Epithelial CellsWei Cui, Zhijun Huang, Gerd P. Pfeifer · 2022 · International Journal of Molecular Sciences
- Les xénobiotiques, quel impact sur les maladies métaboliques ?Laurence Therese HUC, Sylvie Bortoli, Xavier Coumoul · 2019 · Cahiers de Nutrition et de Diététique
- Protein Hyperacylation Links Mitochondrial Dysfunction with Nuclear OrganizationJohn A. Smestad, Micah J. McCauley, Matthew Amato, Yuning Xiong, Juan Liu, Yi-Cheng Sin, Jake Ellingson, Yue Chen, Fatimah J. Al Khazal, Brandon A. Wilbanks et al. · 2020 · SSRN Electronic Journal
- Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancerDongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu et al. · 2020 · arXiv (Cornell University)
- Illuminating histidine phosphorylation in the pancreatic tumor microenvironmentNatalie Luhtala, Nikki K. Lytle, Kathleen E. DelGiorno, Yu Shi, Razia F. Naeem, Michael Anthony Hollingsworth, Susan M. Kaech, Geoffrey M. Wahl, Tony R. Hunter · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Hereditary leiomyomatosis and renal cell cancer (HLRCC), pheochromocytoma (PCC)/paraganglioma (PGL) and germline fumarate hydratase (FH) variantsJohn J. Orrego, Joseph A. Chorny · 2024 · Endocrinology Diabetes and Metabolism Case Reports
- Metabolic Effects of the Cancer Metastasis Modulator MEMO1Marziyeh Ghanbarian, Natalia V. Dolgova, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah L. Michel, Anas El‐Aneed, Oleg Y. Dmitriev · 2025 · Metabolites
- Carcinogenesis trajectoriesRui Wang, Zhaopeng Yan · 2025 · Frontiers in Cell and Developmental Biology
- Prokaryotic organelle mitochondria drive tumorigenesis: “the original sin”Chaoyi Wang, Ming Luo, Jinhui Zhou, Qihao Zhang, Ji Xiawei, Jiayao He, Lingfei Wang, Yingpeng Huang, Xue Xu, 王方岩 · 2026 · Frontiers in Oncology
- α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancerSilvia Malatesta, Virginia Vigiano Benedetti, Emanuela Salviati, Barbara Illi, Isabella Manni, Emanuele Middonti, Gian Luca Rampioni Vinciguerra, Valerio Licursi, Francesca Troilo, Gianni Colotti et al. · 2026 · Cell Death and Disease
- Context-dependent synthetic lethality — an emerging precision therapeutic approachLiang Chang, Katharin L. Shaw, Francisca Vázquez, William R. Sellers · 2026 · Nature reviews. Cancer
- Management of Locally Advanced and Metastatic Pheochromocytoma and ParagangliomaAlejandro Román-Gonzaléz, Paola Jiménez Vásquez, Samuel M. Hyde, Aaron Jessop, Camilo Jiménez · 2016 · Springer eBooks
- Pheochromocytoma/Paraganglioma: Update on Diagnosis and ManagementIvana Jochmanová, Karel Pacák · 2017 · Contemporary Endocrinology
- Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone MethylationFrancisco Saavedra, Ekaterina Boyarchuk, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola · 2019 · RNA technologies
- Role of succinate dehydrogenase in hepatocellular carcinomaGowru Srivani, Mohammad Imran, Neha Merchant, Jyothi Priya Mandala, Ganji Purnachandra Nagaraju · 2022 · Elsevier eBooks
- A big picture of the mitochondria-mediated signals: From mitochondria to organismNeşe Vardar Acar, Rıza Köksal Özgül · 2023 · Biochemical and Biophysical Research Communications
- Pheochromocytoma and ParagangliomaEleonora P.M. Corssmit, Leonie Theresia van Hulsteijn · 2024 · Springer eBooks
- PBK as a Potential Biomarker and Therapeutic Target for Metastatic Pheochromocytomas and ParagangliomasYue Zhou, Wenqian Zhang, Yunying Cui, Tianyi Li, Zewen Li, Anli Tong · 2025 · The Journal of Clinical Endocrinology & Metabolism
- MYC Regulation of Metabolism and CancerArvin M. Gouw, Annie Lee Hsieh, Zachary E. Stine, Chi Van Dang · 2015 · Springer eBooks
- Pheochromocytoma in a Twelve-Year-Old Girl with SDHB-Related Hereditary Paraganglioma-Pheochromocytoma SyndromeDaryl Graham, Megan Gooch, Zhan Ye, Edward J. Richer, Aftab S. Chishti, Elizabeth A. Reilly, John August D'Orazio · 2014 · Case Reports in Genetics
- Models of Pheochromocytoma: What’s on the Horizon?Arthur S. Tischler, Judith Favier · 2015 · International Journal of Endocrine Oncology
- Successful induction therapy with sequential CVD followed by high-dose lanreotide in for metastatic SDHB paraganglioma: Case reportIsabel Tena, José Luis Ponce, Marcos Tajahuerce, Jose Luis Vercher-Conejero, Manuel Cifrián, Katherine I. Wolf, Marcela Miret, María Isabel Del Olmo-García, Rosa Reboll, Antonio Jose Conde-Moreno et al. · 2017 · Journal of Clinical and Translational Endocrinology Case Reports
- Setting Up a LaboratoryLoren J. Joseph · 2015 · Elsevier eBooks
- Repair of retrohepatic inferior vena cava injury.Ahmed Khan Chaudhry, Muhammad Azam, Rasikh Maqsood · 2003 · PubMed
- Pathology of Pheochromocytoma and ParagangliomaJohn Turchini, Anthony James Gill, Arthur S. Tischler · 2018 · Contemporary Endocrinology
- Neuroendocrine NeoplasmsJim Smith, Edward Barnett, Euan James Rodger, Aniruddha Chatterjee, Rathan M. Subramaniam · 2023 · PET Clinics
- Genetic Alterations in Pheochromocytoma and ParagangliomaJenny Welander · 2015 · Linköping University medical dissertations
- Targeting Histone MethylationMarco P. Licciardello, Stefan Kubicek · 2016 · Elsevier eBooks
- The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulationKarim Abid, Maja Beck Popovic, Katia Balmas Bourloud, Jacqueline Schoumans, Joana Grand-Guillaume, Eric Grouzmann, Annick Mühlethaler‐Mottet · 2021 · Oncotarget
- Cancer MetabolismNatalya N. Pavlova, Craig B. Thompson · 2016 · Wiley eBooks
- Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesisYi Xiao, Diana D. Shi, Lei Guo, Ethan Neumann, Michael M. Levitt, Pranita Kaphle, Tracey E. Shipman, Haocheng Li, Feng Cai, Denise M. O. Ramirez et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- The 3PAs syndrome and succinate dehydrogenase deficiency in pituitary tumorsParaskevi Xekouki, Vasiliki N. Daraki, Grigoria Betsi, Maria Chrysoulaki, Maria Sfakiotaki, Maria G. Mytilinaiou, Constantine A. Stratakis · 2021 · Elsevier eBooks
- Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature reviewYuriko Sasaki, Maki Kanzawa, Masaaki Yamamoto, Keitaro Kanie, Hironori Bando, Kei Yoshino, Yushi Hirota, Katsumi Shigemura, Masato Fujisawa, Wataru Ogawa et al. · 2023 · Endocrine Journal
- Molecular Developments in Parasellar Tumors and Potential Therapeutic ImplicationsParaskevi Xekouki, Vasiliki Venetsanaki, Georgios Kyriakopoulos, Krystallenia Alexandraki, Anna G. Angelousi, Gregory Kaltsas · 2024 · Endocrine Reviews
- A Mathematical Exploration of SDH-b Loss in Chromaffin CellsElías Vera-Sigüenza, Himani Rana, Ramin Nashebi, Ielyaas Cloete, Katarína Kl’uvčková, Fabian Spill, Daniel A. Tennant · 2025 · Bulletin of Mathematical Biology
- PGL-EXPO feasibility study of exposure to SDHi fungicides and risk of hereditary SDHx paraganglioma or pheochromocytomaAstrid Coste, Alexandre Buffet, Margaux Duboeuf, Sabrina Boudif, Lény Grassot, Boutheina Ouelaa, Annabelle Sueur, Timgad Lounis, Olivia Pérol, Béatrice Fervers et al. · 2025 · Scientific Reports
- A metabolic–epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibitionYi Fan, Dakota J. Nuttall, Yi Zhao, Dina Abbasian, Clarissa A. Shoffler, Christopher J. Petucci, Wyatt G. Paltzer, Yu-Ling Chang, James Marchant, Diana Presas-Ramos et al. · 2026 · Nature Cardiovascular Research
- Metastatic progression of pheochromocytoma and paraganglioma occurs via parallel evolutionAndrew Marcel Pregnall, Bradley Stephen Wubbenhorst, Kurt D’Andrea, John B. Pluta, Wajid Amjad, Jake S. Shilan, Debbie L. Cohen, Benita Weathers, Bonita Bennett, Maria Bonanni et al. · 2026 · npj Precision Oncology
- Succinate dehydrogenase-deficient cancer cells have increased susceptibility to Ym155-induced DNA damageQianjin Guo, Sooyeon Lee, N. Armstrong, Brian Lim, Rebecca C. Schugar, David Tomz, Haixia Xu, Anzel Zhen, Leor Needleman, Electron Kebebew et al. · 2026 · Endocrine Related Cancer
- The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and AtherosclerosisSanjana C. Basak, Delphine A Gomez · 2026 · Biomolecules
- The Role of the Surgical Pathologist in the Recognition of Hereditary SDH-Deficient Tumor SyndromesC. Christofer Juhlin, Özgür Mete · 2026 · Advances in Anatomic Pathology
- Epigenetic links to the web of KrebsDarren J. Burgess · 2013 · Nature reviews. Cancer
- Mechanisms of Arsenic Toxicity in Humans: Interplay of Arsenic, Glutathione, and DNA Methylation in Bangladeshi AdultsMegan M. Niedzwiecki · 2014
- Exome sequencing and SDH (A, B) immunohistochemistry of canine PheochromocytomasFiras Mohammed Abed, Michael James Dark · 2022 · Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences
- Succinate dehydrogenase variants in paraganglioma: why are B subunit variants ‘bad’?Lucinda Gruber, Steven N. Hart, Louis James Maher III · 2023 · Endocrine Oncology
- SDHx mutations are associated with the PI3K-Akt signaling pathway in vagal paragangliomasAnastasiya V. Snezhkina, Maria Fedorova, Asiya F. Ayupova, Elena A. Pudova, Anastasiya A. Kobelyatskaya, Dmitry Valerievich Kalinin, Alexander Leonidovich Golovyuk, George Sergeevich Krasnov, Vladislav Pavlov, Anna V. Kudryavtseva · 2023 · Archive of oncology
- Mitochondrial Energy Metabolism in CarcinogenesisNatalia Kurhaluk, Halina Tkaczenko · 2024 · Interdisciplinary cancer research
- Metastatic Malignant Paraganglioma of Rare Sites Failed on Conventional Treatments Demonstrating Beneficial Response to 177Lu-DOTATATE PRRTYeshwanth Edamadaka, Munita Meenu Bal, Swapnil Ulhas Rane, Rahul Vithalrao Parghane, Sandip Kanti Basu · 2024 · World Journal of Nuclear Medicine
- Advances and insights in cancer metabolism and epigenetic reprogrammingYirong Zeng, Pu Wang, Dan Ye · 2025 · Chinese Science Bulletin (Chinese Version)
- Approaches to reduce succinate accumulation by restoration of succinate dehydrogenase activity in cultured adrenal cellsFatimah J. Al Khazal, Leili Rahimi, Fan Feng, Nicole A. Becker, Clifford D.L. Folmes, Judith Favier, Louis James Maher III · 2025 · Journal of Cell Science
- Radionuclide Imaging of Pheochromocytoma and Paraganglioma in the Era of Multi-omicsHenri J L M Timmers · 2016 · Springer eBooks
- The epigenomic impact of methylation in metabolic dysfunction and cancerCynthia A. Zahnow · 2019 · Elsevier eBooks
- Role of microenvironment on neuroblastoma SK-N-AS SDHB silenced cell metabolism and functionElena Rapizzi, Rossella Fucci, Elisa Giannoni, Letizia Canu, Susan Richter, Paolo Cirri, Massimo Mannelli · 2015 · Endocrine Abstracts
- Tumors of the adrenal glands : genetic and diagnostic aspectsFredrika Svahn · 2020 · Figshare
- Patient-derived xenograft studies of fumarate hydratase (FH)-deficient uterine leiomyoma subtypeTakuya Kajimura, Vanida Ann Serna, Emma G Amurgis, Michael L. Blumenfeld, Takeshi Kurita · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Distinct proteomic and acylproteomic adaptations to succinate dehydrogenase loss in two cell contextsSherry X. Zhou, Benjamin J. Madden, Cristine M. Charlesworth, Taro Hitosugi, Judith Favier, Louis James Maher III · 2026 · Journal of Biological Chemistry
- Mutations de gènes impliqués dans le métabolisme énergétique et cancerConstance Thibault, Anne‐Paule Gimenez‐Roqueplo · 2013 · ONCOLOGIE
- Mitochondrial Complex II in CancerKatarína Kľučková, Jiřı́ Neužil, Jakub Rohlena · 2014 · Springer eBooks
- Mitochondria : a target for anticancer therapyBjörn Kruspig · 2014 · Figshare
- Succinate Dehydrogenase Deficiency in Sporadic Pituitary Adenomas: A Potential Mechanism for TumorigenesisE.L. Andrews, Stacey K. Mardekian, Markku Miettinen, Mark T. Curtis · 2014
- Genetics of PheochromocytomaVictoria L. Martucci, Karel Pacák · 2014 · Wiley eBooks
- Mutations de la succinate déshydrogénase et méthylation de l’ADNJudith Favier, Éric Letouzé · 2013 · médecine/sciences
- Genetic and molecular background of pheochromocytoma and paragangliomaAdam Stenman · 2015 · Figshare
- Addressing the Core of Carcinogenesis: How a Mitochondrial Mutation Leads to Metabolic Remodeling in Familial CancersAntonio DE FLORA, Silvio De Flora · 2015 · JNCI Journal of the National Cancer Institute
- MEN以外の家族性副腎髄質腫瘍 : Pheochromocytoma/Paragangliomaと遺伝子異常 (特集 多発性内分泌腫瘍症(MEN)以外の家族性内分泌外科疾患)一博 竹越 · 2015 · 日本内分泌・甲状腺外科学会雑誌
- Revue des travaux menés par le programme cartes d’identité des tumeurs sur les tumeurs endocrines : impacts sur la pathologie et la prise en charge des patientsAurélien de Reyniès · 2016 · Annales d Endocrinologie
- Molecular characterisation of renal cell carcinoma and related disordersMariam Jafri · 2016 · University of Birmingham Institutional Research Archive (University of Birmingham)
- Tumor Metabolism and Metabolomics of Pheochromocytomas and ParagangliomasSusan Richter, Graeme Eisenhofer · 2016 · Springer eBooks
- Molecular Genetics of Pheochromocytoma and ParagangliomaMercedes Robledo, María Currás-Freixes, Alberto Cascón · 2016 · Springer eBooks
- Radionuclide Imaging of Head and Neck ParagangliomasDavid Taïeb, Arthur Damien Varoquaux, Ingo Janssen, Karel Pacák · 2016 · Springer eBooks
- Elucidating The Role of MifS-MifR Two-Component System in Regulating Pseudomonas aeruginosa PathogenicityGorakh Tatke · 2016
- Metabolic Feedback Control through H3K4 DemethylationMaria Soloveychik · 2016 · TSpace (University of Toronto)
- Energy Metabolism and EpigeneticsScott J. Bultman · 2017 · Springer eBooks
- Pheochromocytomas and Paragangliomas: Genetics and PathophysiologyLauren Michelle Fishbein · 2017 · Contemporary Endocrinology
- Paroxysmal Hypertension: PheochromocytomaGraeme Eisenhofer, Jacques W.M. Lenders · 2017 · Updates in hypertension and cardiovascular protection
- Hereditary paraganglioma : genetics and tumor biologyAttje S. Hoekstra · 2017 · Leiden Repository (Leiden University)
- Pheochromocytoma/Paraganglioma: Management, Genetics, and Follow-upAnne‐Paule Gimenez‐Roqueplo, Laurence Amar · 2018 · Elsevier eBooks
- Biomarkers in pheochromocytomas and paragangliomasHelena Leijon · 2018 · Työväentutkimus Vuosikirja
- Feocromocitoma asociado a leiomiomatosis cutánea y uterina y cáncer renal en un paciente con una mutación germinal en el gen de la fumarato hidratasaMarta Morón, Juan Luis Afonso, Mauro Boronat · 2019 · Endocrinología Diabetes y Nutrición
- Metabolite-Sensing and Human DiseasesShimin Zhao, Jian‐Yuan Zhao · 2016 · Scientia Sinica Vitae
- 40-Year Follow-Up of a Patient with Multiple Paragangliomas and a SDHD MutationAtanaska P. Elenkova · 2019 · Acta Endocrinologica (Bucharest)
- Targeted next-generation sequencing detects rare genetic events in pheochromocytoma and paragangliomaLaurène Ben Aim, Pascal Pigny, Luis Jaime Castro‐Vega, Alexandre Buffet, Laurence Amar, Jerome Yves Bertherat, D. Drui, Isabelle Guilhem, Éric Baudin, Charlotte Lussey‐Lepoutre et al. · 2019 · Yearbook of pediatric endocrinology
- Pheochromocytoma associated with cutaneous and uterine leiomyomatosis and renal cancer in a patient with a germline mutation in the fumarate hydratase geneMarta Morón, Juan Luis Afonso, Mauro Boronat · 2020 · Endocrinología Diabetes y Nutrición (English ed )
- Mutations de gènes impliqués dans le métabolisme énergétique et cancer Genetic mutations involved in energy metabolism and cancerConstance Thibault · 2013
- Familial Paraganglioma Pheochromocytoma Syndrome, SDH RelatedVânia Nosé · 2018 · Elsevier eBooks
- Metastatic Paragangliomas and Pheochromocytomas: An Epigenetic ViewMaría‐Dolores Chiara, Lucía Celada, Andrés San José Martínez, Tamara Cubiella, Enol Álvarez-González, Nuria Valdés · 2021 · IntechOpen eBooks
- Succinate Dehydrogenase Mutation and Paraganglioma Syndromes: A Review ArticlePooja Ramakant · 2021 · Indian Journal of Endocrine Surgery and Research
- A chemical screen for suppressors of dioxygenase inhibition in a yeast model of familial paragangliomaWilliam F. Beimers, Megan M. Braun, Kaleb Schwinefus, Keenan S. Pearson, Brandon A. Wilbanks, Louis James Maher III · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Selección de poemas inéditos conservados en el Archivo Juan Gil-Albert de la Biblioteca ValencianaPilar Escobedo Cubells, Juan Francisco Morales Ferrer · 2004 · Laberintos: revista de estudios sobre los exilios culturales españoles
- Aggiornamenti sulla prima fase di CapuaWerner Johannowsky · 2025 · Annali di archeologia e storia antica
- Succinate Uptake by T Cells Suppresses Their Anti-Tumour Function Via Inhibition of Mitochondrial Glucose OxidationNancy H. Gudgeon, Haydn Munford, Emma L. Bishop, James Hill, Taylor Fulton-Ward, David Bending, Jennie Roberts, Daniel A. Tennant, Sarah Dimeloe · 2021 · SSRN Electronic Journal