The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Beclin 1 interactome
Open accessAbstract
The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases. In recent years, major advances have been made in identifying components of functionally distinct Beclin 1/class III phosphatidylinositol 3-kinase complexes, in characterizing the molecular regulation of interactions between Beclin 1 and the autophagy inhibitors, Bcl-2/BcL-XL, and in uncovering a role for viral antagonists of Beclin 1 in viral pathogenesis. The rapidly growing list of components of the ‘Beclin 1 interactome’ supports a model in which autophagy, and potentially other membrane trafficking functions of Beclin 1, are governed by differential interactions with different binding partners in different physiological or pathophysiological contexts.
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Autophagy in the Pathogenesis of Disease
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Self-citationRegulation mechanisms and signaling pathways of autophagy
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Self-citationInduction of autophagy and inhibition of tumorigenesis by beclin 1
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Self-citationPromotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
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Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
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Cited by
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Self-citationTFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
Self-citationThe Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Autophagy in mammalian development and differentiation
Mizushima, N., & Levine, B. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-823 · Cited by 1,555
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Metadata
- Authors
- He, C., & Levine, B.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 22
- Issue
- 2
- Pages
- 140-149
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2003380425
- Cited by
- 659
- References
- 18
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- green
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