High-throughput approaches for the analysis of extrinsic regulators of stem cell fate
Open accessAbstract
The complexity of stem cell niches poses a tremendous challenge to understanding mechanisms of extrinsic regulation of stem cell fate. In order to better understand niche signaling and its effect on stem cell fate choices, in vitro systems are being engineered which recapitulate, in a simplistic but increasingly sophisticated manner, native stem cell niches. New technologies or new combinations of existing technologies allow more systematic ways to probe niche signaling in high-throughput. Systems biology approaches in experimental design, data acquisition and analysis will be necessary to tackle the challenges that lie ahead.
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Synthetic polymer-based culture allows organoid formation conditions to be evaluated using high-throughput methods.
“Synthetic polymer-based culture allows organoid formation conditions to be evaluated using high-throughput methods143–145.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [143]
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References 54 · Cited by 59
- Authors
- Ranga, A., & Lutolf, M. P.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- ORCID
- Ranga, Adrian
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 24
- Issue
- 2
- Pages
- 236-244
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W1981071118
- Cited by
- 59
- References
- 54
- Citations by year
- 2024: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 6
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- stem cell fate, extrinsic regulation, stem cell niche, niche signaling, high-throughput screening, systems biology, stem cell differentiation
- MeSH terms
- Animals, Cell Differentiation, Hematopoietic Stem Cells, Humans, Stem Cells, Signal Transduction, Systems Biology, Stem Cell Niche
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