The molecular machines that traffic signaling receptors into and out of cilia
Open accessAbstract
Cilia are surface-exposed organelles that dynamically concentrate signaling molecules to organize sensory, developmental and homeostatic pathways. Entry and exit of signaling receptors is germane to the processing of signals and the molecular machines for entry and exit have started to emerge. The IFT-A complex and its membrane recruitment factor Tulp3 complex promotes the entry of signaling receptors into cilia while the BBSome and its membrane recruitment factor Arl6 GTP ferry activated signaling receptors out of cilia. Ciliary exit is a surprisingly complex process entailing passage through a first diffusion barrier at the transition zone, diffusion inside an intermediate compartment and crossing of a periciliary diffusion barrier. The two barriers may organize a privileged compartment where activated signaling receptors transiently reside.
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BBSome proteins were initially thought to facilitate delivery of GPCRs to cilia, but it has been proposed that they primarily regulate ciliary export of signalling proteins.
“The BBSome proteins were initially thought to facilitate the delivery of GPCRs to cilia 73–75; however, it has been proposed that BBSome proteins primarily regulate ciliary export of signalling proteins 72, 76, 77, 78.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [77]
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References 70 · Cited by 176
- Authors
- Nachury, M. V.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Nachury, Maxence V
- ORCID
- Nachury, Maxence V
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 51
- Pages
- 124-131
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC5949257
- OpenAlex
- W2794015613
- Cited by
- 176
- References
- 70
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 17 · 2023: 19 · 2022: 31 · 2021: 26 · 2020: 27 · 2019: 24 · 2018: 9 · 2014: 1
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Opinion in Cell Biology (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Eye Institute (EY002162)
- Research to Prevent Blindness
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- cilia, signaling receptors, receptor trafficking, IFT-A complex, BBSome, transition zone, primary cilia, sensory signaling
- MeSH terms
- Cilia, Humans, Signal Transduction, Protein Transport
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