The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
SOX9 in cartilage development and disease
Open accessAbstract
SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis. Its mandatory role in transactivating many cartilage-specific genes is well established, whereas a pioneer role in lineage specification, which along with transactivation defines master transcription factors, remains elusive. Abundant, but yet incomplete evidence exists that intricate molecular networks control SOX9 activity during the multi-step chondrogenesis pathway. They include a highly modular genetic regulation, posttranscriptional and posttranslational modifications, and varying sets of functional partners. Fully uncovering SOX9 actions and regulation is fundamental to explain mechanisms underlying many diseases that directly or indirectly affect SOX9 activity and to design effective disease treatments. We here review current knowledge, highlight recent discoveries, and propose new research directions to answer remaining questions.
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Cites
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Interactions between Sox9 and β-catenin control chondrocyte differentiation
Akiyama, H., Lyons, J. P., Mori-Akiyama, Y., Yang, X., Zhang, R., Zhang, Z., Deng, J. M., Taketo, M. M., Nakamura, T., Behringer, R. R., et al. (2004) · Genes & Development · doi:10.1101/gad.1171104 · Cited by 754
Formation of new chromatin domains determines pathogenicity of genomic duplications
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The Transcription Factors L-Sox5 and Sox6 Are Essential for Cartilage Formation
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Self-citationSox proteins: regulators of cell fate specification and differentiation
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Cited by
Stojceski, F., Buetti-Dinh, A., Stoddart, M. J., Danani, A., Della Bella, E., & Grasso, G. (2023) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2023.108587 · Cited by 12
Metadata
- Authors
- Lefebvre, V., Angelozzi, M., & Haseeb, A.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 61
- Pages
- 39-47
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2964695565
- Cited by
- 268
- References
- 65
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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