Experimental measurement and modelling of reactive species generation in TiO2 nanoparticle photocatalysis
Open accessAbstract
The generation of reactive species in titanium dioxide (TiO 2) nanoparticle photocatalysis was assessed in a laboratory scale setup, in which P25 Aeroxide TiO 2 suspensions were photoactivated by means of UV-A radiation. Photogenerated holes and hydroxyl radicals were monitored over time by observing their selective reaction with probe compounds, iodide and terephthalic acid, respectively. TiO 2 aggregate size and structure were characterized over the reaction time. Reactive species quenching was then described by a model, accounting for radiative phenomena, TiO 2 nanoparticle aggregation and kinetic reactions. The interaction between iodide and photogenerated holes was influenced by iodide adsorption on TiO 2 surface, described by a Langmuir-Hinshelwood mechanism, whose parameters were studied as a function of TiO 2 concentration and irradiation time. Iodide oxidation was effectively simulated by modelling the reaction volume as a completely stirred two-dimensional domain, in which irradiation phenomena were described by a two-flux model and the steady state for reactive species was assumed. The kinetic parameters for iodide adsorption and oxidation were estimated and successfully validated in a different experimental setup. The same model was adapted to describe the oxidation of terephthalic acid by hydroxyl radicals. The kinetic parameters for terephthalic acid oxidation were estimated and validated, while the issues in investigating the interaction mechanisms among the involved species have been discussed. The sensitivity of operating parameters on model response was assessed and the most relevant parameters were highlighted.
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PDT produces ROS that induce tumor cell death by stimulating photosensitizers with specific wavelengths of therapeutic light.
“PDT can produce ROS that induce tumor cell death by stimulating photosensitizers with specific wavelengths of therapeutic light [101–103].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [102]
The Introduction (§1.1; page not provided) says that illuminating TiO2 with photons of an appropriate wavelength produces ROS. The paper studies TiO2 photocatalysis for applications such as water treatment; it does not establish that photodynamic therapy using photosensitizers induces tumor-cell death. (LLM, conf=0.85)
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Nanosensitizer-assisted sonodynamic therapy for breast cancer
Yu, J., Hu, J.-R., Tian, Y., Lei, Y.-M., Hu, H.-M., Lei, B.-S., Zhang, G., Sun, Y., & Ye, H.-R. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03311-3 · Cited by 43 · see citing works
- Authors
- Turolla, A., Piazzoli, A., Farner Budarz, J., Wiesner, M. R., & Antonelli, M.
- Affiliations
- Politecnico di Milano (IT)
- Duke University (US)
- Corresponding author
- Antonelli, Manuela
- Venue
- Chemical Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 271
- Pages
- 260-268
- ISSN
- 1385-8947 (ISSN-L)
- PMC
- PMC5119892
- OpenAlex
- W1979075162
- Cited by
- 40
- References
- 1
- Citations by year
- 2025: 5 · 2024: 5 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Engineering Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion, other-oa)
- Funders
- National Institute of Environmental Health Sciences (ES010356, P42ES010356)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › TiO2 Photocatalysis and Solar Cells
- Physical Sciences › Environmental Science › Water Science and Technology › Advanced oxidation water treatment
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Advanced Photocatalysis Techniques
- Keywords
- reactive species generation, photogenerated holes, hydroxyl radicals, iodide oxidation, two-flux model, kinetic modeling, UVA irradiation
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