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Cited by 290Neuroscience and Neuropharmacology ResearchCellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity

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Junge, Harald J., Rhee, Jeong-Seop, Jahn, Olaf, Varoqueaux, Frederique, Spiess, Joachim, Waxham, M.Neal, Rosenmund, Christian, Brose, Nils·2004·Cell
DOI 10.1016/j.cell.2004.06.029
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Abstract

The efficacy of synaptic transmission between neurons can be altered transiently during neuronal network activity. This phenomenon of short-term plasticity is a key determinant of network properties; is involved in many physiological processes such as motor control, sound localization, or sensory adaptation; and is critically dependent on cytosolic [Ca2+]. However, the underlying molecular mechanisms and the identity of the Ca2+ sensor/effector complexes involved are unclear. We now identify a conserved calmodulin binding site in UNC-13/Munc13s, which are essential regulators of synaptic vesicle priming and synaptic efficacy. Ca2+ sensor/effector complexes consisting of calmodulin and Munc13s regulate synaptic vesicle priming and synaptic efficacy in response to a residual [Ca2+] signal and thus shape short-term plasticity characteristics during periods of sustained synaptic activity.

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  • The calmodulin-binding sequence of Munc13 is implicated in short-term synaptic plasticity.

    “The third signaling motif of Munc13’s, their calmodulin-binding sequence, is also implicated in short-term synaptic plasticity”

    From The Presynaptic Active Zone (2012) · cites this paper as Junge et al., 2004

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References 35 · Cited by 290

Authors
Junge, H. J., Rhee, J.-S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M. N., Rosenmund, C., & Brose, N.
Affiliations
  • Max Planck Society (DE)
  • The University of Texas Health Science Center at Houston (US)
  • Max Planck Institute for Biophysical Chemistry (DE)
Corresponding author
Brose, Nils
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2004-08
Volume
118
Issue
3
Pages
389-401
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2004.06.029
OpenAlex
W1994684691
Cited by
290
References
35
Citations by year
2026: 5 · 2025: 11 · 2024: 3 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 22 · 2016: 8 · 2015: 10 · 2014: 17 · 2013: 16 · 2012: 10
FWCI
6.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • GRO (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
calmodulin, Munc13, UNC-13, short-term plasticity, synaptic vesicle priming, synaptic efficacy, calmodulin binding site, intracellular calcium
MeSH terms
Animals, Binding Sites, Calcium, Calmodulin, Nerve Tissue Proteins, Intracellular Signaling Peptides and Proteins, Mice

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