An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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Items 101–200 of 1,001

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4. Structural Basis of the Unfolded Protein Response
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6. Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
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7. c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty
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10. Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers
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18. Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”
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19. SnapShot: EGFR Signaling Pathway
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20. EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
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21. Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
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23. Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation
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24. EGFR-mutated lung cancer: a paradigm of molecular oncology
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25. The secret life of kinases: functions beyond catalysis
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26. Ligand-Independent EGFR Signaling
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27. Emergence of Epidermal Growth Factor Receptor T790M Mutation during Chronic Exposure to Gefitinib in a Non–Small Cell Lung Cancer Cell Line
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28. Ras-Mediated Activation of the Raf Family Kinases
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29. Molecular basis for multimerization in the activation of the epidermal growth factor receptor
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30. Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase
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31. Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy
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32. Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy
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35. Mechanisms of drug resistance in kinases
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36. Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases
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37. Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling
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39. Characterization of Chemical Libraries for Luciferase Inhibitory Activity
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40. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
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41. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
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42. Catalytic Mechanisms and Regulation of Protein Kinases
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43. Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase
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44. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system
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45. Structural Basis for the Non-catalytic Functions of Protein Kinases
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46. Amplification of EGFR Wild-Type Alleles in Non–Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors
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47. Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation
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48. ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium
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49. Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver
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50. Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements
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52. The Mysterious Ways of ErbB2/HER2 Trafficking
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53. Activating HER2 mutations as emerging targets in multiple solid cancers
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54. Signal processing by the endosomal system
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55. Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies
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56. The Genesis of Tyrosine Phosphorylation
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57. <i>In vitro</i> modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant <i>EGFR</i> mutants in non-small-cell lung cancer
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58. Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
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60. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1
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61. Investigation of the Dimerization of Proteins from the Epidermal Growth Factor Receptor Family by Single Wavelength Fluorescence Cross-Correlation Spectroscopy
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62. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
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63. Regulation of EGFR nanocluster formation by ionic protein-lipid interaction
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64. Somatic Mutations in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor (EGFR) Abrogate EGFR-Mediated Radioprotection in Non–Small Cell Lung Carcinoma
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65. Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation
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66. Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2
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68. Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling
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69. AGC kinases, mechanisms of regulation and innovative drug development
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70. Crystal Structure of a Human IκB Kinase β Asymmetric Dimer
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71. Protein kinase biochemistry and drug discovery
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72. Turning a protein kinase on or off from a single allosteric site via disulfide trapping
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74. Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization
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75. Structure and dynamics of the EGFR/HER2 heterodimer
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77. Mechanism for activation of mutated epidermal growth factor receptors in lung cancer
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78. ERBB3/HER3 and ERBB2/HER2 Duet in Mammary Development and Breast Cancer
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79. The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3
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80. ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
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81. The insulin and EGF receptor structures: new insights into ligand-induced receptor activation
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82. Signals and Receptors
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83. Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
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84. A single ligand is sufficient to activate EGFR dimers
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85. Prospects for pharmacological targeting of pseudokinases
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86. <i>EGFR</i> Fusions as Novel Therapeutic Targets in Lung Cancer
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87. The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics
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88. Pseudokinases-remnants of evolution or key allosteric regulators?
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89. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases
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90. Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy
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91. Clinical outcomes in non‐small‐cell lung cancer patients with EGFR mutations: pooled analysis
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92. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation
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93. Protein interface classification by evolutionary analysis
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94. Receptor tyrosine kinase inhibitors in cancer
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97. Kinases and Pseudokinases: Lessons from RAF
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98. Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface
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99. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor
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100. Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
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