Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells
Open accessAbstract
Stem cells (SC) exhibit a unique capacity for self-renewal in an undifferentiated state. It is unclear whether the self-renewal of pluripotent embryonic SC (ESC) and of tissue-specific adult SC such as hematopoietic SC (HSC) is controlled by common mechanisms. The deletion of transcription factor Zfx impaired the self-renewal but not the differentiation capacity of murine ESC; conversely, Zfx overexpression facilitated ESC self-renewal by opposing differentiation. Furthermore, Zfx deletion abolished the maintenance of adult HSC but did not affect erythromyeloid progenitors or fetal HSC. Zfx-deficient ESC and HSC showed increased apoptosis and SC-specific upregulation of stress-inducible genes. Zfx directly activated common target genes in ESC and HSC, as well as ESC-specific target genes including ESC self-renewal regulators Tbx3 and Tcl1. These studies identify Zfx as a shared transcriptional regulator of ESC and HSC, suggesting a common genetic basis of self-renewal in embryonic and adult SC.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tbx3 is involved in the carcinogenesis of multiple types of human cancers.
“As Tbx3 is involved in the carcinogenesis of multiple types of human cancers, our findings suggest an important target for anti-cancer drug development.”
The citation lists haven’t been fetched yet
References 42 · Cited by 244
- Authors
- Galan-Caridad, J. M., Harel, S., Arenzana, T. L., Hou, Z. E., Doetsch, F. K., Mirny, L. A., & Reizis, B.
- Affiliations
- Columbia University Irving Medical Center (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Corresponding author
- Reizis, Boris
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 129
- Issue
- 2
- Pages
- 345-357
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC1899089
- OpenAlex
- W2137903841
- Cited by
- 244
- References
- 42
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 16 · 2017: 6 · 2016: 13 · 2015: 10 · 2014: 18 · 2013: 21 · 2012: 21
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society
- March of Dimes Foundation
- National Heart, Lung, and Blood Institute (HL084353, R01HL084353)
- National Institute of Allergy and Infectious Diseases (T32AI007525, R21AI085439, AI007525, R01AI072571, AI 066459, F31AI066459)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- ZFX, transcription factors, stem cell self-renewal, embryonic stem cells, hematopoietic stem cells, pluripotency, apoptosis, stress-inducible genes, TBX3, TCL1, transcriptional regulation, hematopoiesis
- MeSH terms
- Animals, Cell Differentiation, Female, Hematopoietic Stem Cells, Male, Proto-Oncogene Proteins, Gene Expression, Apoptosis, Gene Targeting, T-Box Domain Proteins, Cell Proliferation, Mice, Kruppel-Like Transcription Factors, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
