Nuclear Translocation of CAM-Associated Protein Activates Transcription for Long-Term Facilitation in Aplysia

Lee, Seung-Hee; Lim, Chae-Seok; Park, Hyungju; Lee, Jin-A; Han, Jin-Hee; Kim, Hyoung; Cheang, Ye-Hwang; Lee, Sue-Hyun; Lee, Yong-Seok; Ko, Hyoung-Gon; Jang, Dong-Hyuk; Kim, Hyongkyu; Miniaci, Maria C.; Bartsch, Dusan; Kim, Eunjoon; Bailey, Craig H.; Kandel, Eric R.; Kaang, Bong-Kiun

doi:10.1016/j.cell.2007.03.041

Nuclear Translocation of CAM-Associated Protein Activates Transcription for Long-Term Facilitation in Aplysia

Repeated pulses of serotonin (5-HT) induce long-term facilitation (LTF) of the synapses between sensory and motor neurons of the gill-withdrawal reflex in Aplysia. To explore how apCAM downregulation at the plasma membrane and CREB-mediated transcription in the nucleus, both of which are required…