Commonality but Diversity in Cancer Gene Fusions
Open accessAbstract
Recent findings of gene fusions in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas decades ago. A recurring feature of carcinoma gene fusions, in contrast to those in hematopoietic and mesenchymal malignancies, is that they result in aberrant cell signaling. This may reflect differences in the differentiation programs of these tissues.
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For most known fusions, the genomic breakpoint is located in an intron of each gene and the fusion boundary coincides with a splice site within each gene.
“For most known fusions, the genomic breakpoint is located in an intron of each gene [92] and the fusion boundary coincides with a splice site within each gene.”
From A survey of best practices for RNA-seq data analysis (2016) · cites this paper as [92]
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References 37 · Cited by 73
- Authors
- Rabbitts, T. H.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- Rabbitts, Terence H.
- ORCID
- Rabbitts, Terence H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 137
- Issue
- 3
- Pages
- 391-395
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2014050706
- Cited by
- 73
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 9 · 2012: 7
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromosomal abnormalities, carcinoma, histogenesis, leukemia, sarcoma, fusion oncogenes
- MeSH terms
- Animals, Breast Neoplasms, Chromosome Aberrations, Female, Humans, Lung Neoplasms, Male, Neoplasms, Prostatic Neoplasms, Oncogene Proteins, Fusion, Oncogene Fusion
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