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Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes
Open accessAbstract
Nuclear pore complexes have recently been shown to play roles in gene activation, however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98 and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct loci that often do not represent NE contact sites. While Nup88 localizes to silent loci, Sec13, Nup98 and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction. Strikingly, RNAi-mediated knockdown of intranuclear Sec13 and Nup98 specifically inhibits transcription of their target genes and prevents efficient reactivation of transcription after heat shock, suggesting an essential role of NPC components in regulating complex gene expression programs of multicellular organisms.
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Cited by
Genome Architecture: Domain Organization of Interphase Chromosomes
Bickmore, W. A., & van Steensel, B. (2013) · Cell · doi:10.1016/j.cell.2013.02.001 · Cited by 725
The Nuclear Pore Complex and Nuclear Transport
Wente, S. R., & Rout, M. P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000562 · Cited by 686
Chromatin higher-order structures and gene regulation
Li, G., & Reinberg, D. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.01.022 · Cited by 454
The Nuclear Pore Complex as a Flexible and Dynamic Gate
Knockenhauer, K. E., & Schwartz, T. U. (2016) · Cell · doi:10.1016/j.cell.2016.01.034 · Cited by 406
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
Gough, S. M., Slape, C. I., & Aplan, P. D. (2011) · Blood · doi:10.1182/blood-2011-07-328880 · Cited by 342
Metadata
- Authors
- Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., & Hetzer, M. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 140
- Issue
- 3
- Pages
- 372-383
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2146614388
- Cited by
- 443
- References
- 0
- FWCI
- 15.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., & Hetzer, M. W. (2010). Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes. Cell. https://doi.org/10.1016/j.cell.2009.12.054
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
