The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Natural Killer Cell Education and Tolerance
Open accessAbstract
Natural killer (NK) cells play a key role in the immune response to certain infections and malignancies by direct cytolysis of infected or transformed cells and by secretion of potent immune mediators. NK cells express an array of activating receptors that recognize self-molecules. If not restrained by inhibitory receptors recognizing major histocompatibility complex (MHC) class I proteins on the surface of self cells, NK cells are able to kill normal healthy cells. Not all NK cells express inhibitory receptors for self-MHC class I; thus, other tolerance mechanisms are necessary to prevent NK cell-mediated autoimmunity. Here we review the major mechanisms of NK cell education and tolerance.
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Cites
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2006) · Nature · doi:10.1038/nature04444 · Cited by 3,986
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
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Self-citationActivating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis
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Up on the tightrope: natural killer cell activation and inhibition
Lanier, L. L. (2008) · Nature Immunology · doi:10.1038/ni1581 · Cited by 1,656
Self-citationAdaptive immune features of natural killer cells
Sun, J. C., Beilke, J. N., & Lanier, L. L. (2009) · Nature · doi:10.1038/nature07665 · Cited by 1,619
Self-citationLicensing of natural killer cells by host major histocompatibility complex class I molecules
Kim, S., Poursine-Laurent, J., Truscott, S. M., Lybarger, L., Song, Y.-J., Yang, L., French, A. R., Sunwoo, J. B., Lemieux, S., Hansen, T. H., et al. (2005) · Nature · doi:10.1038/nature03847 · Cited by 1,340
Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
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Self-citationHuman NK Cell Education by Inhibitory Receptors for MHC Class I
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Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
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Cited by
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Gong, Y., Klein Wolterink, R. G. J., Wang, J., Bos, G. M. J., & Germeraad, W. T. V. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01083-5 · Cited by 379
O’Sullivan, T. E., Sun, J. C., & Lanier, L. L. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.013 · Cited by 349
Self-citationBellucci, R., Martin, A., Bommarito, D., Wang, K., Hansen, S. H., Freeman, G. J., & Ritz, J. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008824 · Cited by 307
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma
Beldi-Ferchiou, A., Lambert, M., Dogniaux, S., Vély, F., Vivier, E., Olive, D., Dupuy, S., Levasseur, F., Zucman, D., Lebbé, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12150 · Cited by 312
Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases
Argyropoulos, C. P., Chen, S. S., Ng, Y.-H., Roumelioti, M.-E., Shaffi, K., Singh, P. P., & Tzamaloukas, A. H. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00073 · Cited by 308
Metadata
- Authors
- Orr, M. T., & Lanier, L. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 142
- Issue
- 6
- Pages
- 847-856
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1964265426
- Cited by
- 441
- References
- 80
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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