EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation
Margolis, Seth S., Salogiannis, John, Lipton, David M., Mandel-Brehm, Caleigh, Wills, Zachary P., Mardinly, Alan R., Hu, Linda, Greer, Paul L., Bikoff, Jay B., Ho, Hsin-Yi Henry, Soskis, Michael J., Sahin, Mustafa, Greenberg, Michael E.·2010·Cell
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- Ephecting Excitatory Synapse DevelopmentMatthew B. Dalva · 2010 · Cell
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- Functional characterization of podocyte-expressed THSD7A in experimental membranous nephropathyMing Huang, Moritz Lassé, Silke Dehde, Felicitas E. Hengel, Fatih Demir, Anja M. Billing, Ning Song, Larissa Seifert, Oliver Kretz, Florian Grahammer et al. · 2026 · JCI Insight
- Developmental disabilities, autism, and schizophrenia at a single locusLawrence T. Reiter · 2020 · Elsevier eBooks
- Angelman syndromeJennifer M. Mathews, Emily K. Cook, Seth S. Margolis, Charles A. Williams · 2020 · Elsevier eBooks
- Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilizationSamuel Petshow, Azariah Coblentz, Andrew M. Hamilton, Dipannita Sarkar, Margarita Anisimova, Juan C. Flores, Karen Zito · 2025 · Science Advances
- The Ubiquitin E3 Ligase UBE3A Regulates GRIPAP1 and PACSIN1 Proteins Linked to the Endocytic Recycling of AMPA ReceptorsLaura Drebushenko, Natalya Belous, Fritz Walter Lischka, Qiong Zhou, Ayse Malci, Michael S. Sidorov, Barrington G. Burnett, Martin L. Doughty · 2025 · Molecular and Cellular Biology
- Genetic Mechanisms of Memory Disorders (Excluding Alzheimer's Disease)Garrett A. Kaas, Kimberly E. Hawkins, J. David Sweatt · 2017 · Elsevier eBooks
- Angelman Syndrome causing UBE3A ligase displays predominantly synaptic ubiquitination activity in the mouse brainUgo Mayor, Unai Alduntzin, Benoit Louis Philippe Lectez, Natalia Presa, Nerea Osinalde, Marta Fernandez, Nagore Elu, Juanma Ramírez, Cristina Garcia-Barcena, Kerman Aloria et al. · 2023 · Research Square
- Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor functionChao Chang, Sara L. Banerjee, Sung Soon Park, Xiaolei Zhang, David Cotnoir‐White, Karla J. Opperman, Muriel Desbois, Brock J. Grill, Artur Kania · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoidsR. Chris Estridge, Z. Begum Yagci, Dilara Sen, Travis Ptacek, Jeremy M. Simon, Albert J. Keung · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Emerging Research towards the Understanding and Treatment of AutismPaul P. Wang, Rebecca Hammond, Friso R. Postma, Aileen M. Healy · 2012 · Royal Society of Chemistry eBooks
- E3 ubiquitin ligases and cerebral cortex development in health and diseaseNicolas Lambert, Martin Moïse, Laurent Nguyen · 2022 · Developmental Neurobiology
- RNAi-Induced Expression of Paternal UBE3AHye Ri Kang, Violeta Zaric, Volodymyr Rybalchenko, Steven J. Gray, Ryan K. Butler · 2026 · Genes
- Enhancing Maturation of Human Neuromuscular Organoids via Electrical StimulationChrysanthi‐Maria Moysidou, Inês B. Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara-Camelia Rusu, Aylin Nebol, Ines Lahmann et al. · 2026 · Advanced Science
- Principles Driving the Spatial Organization of Rho GTPase Signaling at SynapsesScott H. Soderling, Linda Van Aelst · 2014 · Springer eBooks
- RhoGEF Tiam2 Regulates Glutamatergic Synaptic Transmission in Hippocampal CA1 Pyramidal NeuronsSadhna Rao, Feng Liang, Bruce E. Herring · 2024 · eNeuro
- Ubiquitin ligase signalling networks shape presynaptic development, function and diseaseMelissa A. Borgen, Brock J. Grill · 2024 · The Journal of Physiology
- Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3AThomas A. Bregnard, Daniel Fairchild, Xiang Chen, Heidi Erlandsen, Sergey G. Tarasov, Kylie J. Walters, Dmitry M. Korzhnev, Irina Bezsonova · 2024 · Journal of Biological Chemistry
- Transcriptomic Profiling of Mice Primary Cortical Neurons in Response to Medium ChangeJuan Andres Rubiolo, Carmen Vale, Victor Martín, Aida G. Méndez, Andrea Boente-Juncal, Mercedes R. Vieytes, Luis Miguel Botana · 2016 · Transcriptomics Open Access
- Therapeutic Approaches to Imprinting DiseasesHiromitsu Hattori, Hitoshi Hiura, Norio Kobayashi, Souta Takahashi, Hiroaki Okae, Takahiro Arima · 2018 · Elsevier eBooks
- Scaffold Protein Lnx1 Stabilizes EphB Receptor Kinases for SynaptogenesisNa Li, Si Chen, Nan‐Jie Xu, Suya Sun, Jinjin Chen, Xiandong Liu · 2022 · Frontiers in Molecular Neuroscience
- E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug DevelopmentRafael M. Ioris, Katherine Ferris, Vincenzo D’Angiolella · 2022 · Wiley eBooks
- Guided maturation of human neuromuscular organoids via electrical stimulationChrysanthi‐Maria Moysidou, Inês B. Martins, Ismail Amr El‐Shimy, Donatella Cea, Christina Bukas, Isra Mekki, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Ube3a Role in Synaptic Plasticity and Neurodevelopmental Disorders.The Lessons from Angelman Syndrome.Irina Filonova · 2014 · Digital Commons - University of South Florida (University of South Florida)
- Intercellular communication in cortical neuronal elaboration and circuit formation: A role for EphA signalingMeredith A. Clifford · 2012 · Georgetown University-Graduate School of Arts & Sciences
- Minocycline Treatment and the Necessity to Develop a Novel Outcome Measure for Children with Angelman SyndromeJoseph C. Grieco · 2015 · Digital Commons - University of South Florida (University of South Florida)
- The role of E3 ubiquitin ligase FBXO31-SCF in neuronal morphogenesisMayur Vadhvani · 2013 · eDiss (Georg-August-Universität Göttingen)
- A Chemical-Genetic Study of EphB Receptor Tyrosine Kinase Signaling in the Developing Nervous SystemMichael J. Soskis · 2012 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Ephrin B3 (EphB3) receptors expressed in spinal tissue of rats with spinal cord injuryXiaodong Zhi · 2012 · African Journal of Pharmacy and Pharmacology
- A 15q11–q13 Duplication Mouse Model of Autism Spectrum DisordersToru Takumi, Keita Fukumoto, Jun Nomura · 2012 · Elsevier eBooks
- Imprinting in the CNS and Neurodevelopmental DisordersWeston T. Powell, Janine M. LaSalle · 2013 · Elsevier eBooks
- rEviSÃo DE litEratUra A patogênese genética e molecular da síndrome de Angelman The genetic and molecular pathogenesis of the Angelman syndromeAngélica Francesca Maris, Alexis Trott, Síndrome de Angelman · 2011
- Effects of Localized EphB2 Stimulation on Dendritic Filopodia of Hippocampal NeuronsClifford Locke · 2018 · OpenCommons at University of Connecticut (University of Connecticut)
- Disrupted synaptic transmission and abnormal short-term synaptic plasticity in an Angelman syndrome mouse modelGuohui Li · 2017
- Regulation of Dendritic Spine Development and Cell Migration through Asef2-mediated SignalingJ. Corey Evans · 2014
- The Effect of ARHGEF15 Knockout and Forebrain-Specific Human ARHGEF15 Knock-In on Seizure Susceptibility in MiceYidan Liu, Mengyu Ma, Yanling Wang, Mei-Juan Ding, Yang Yu, Jinghui Feng, Yan-Ke Zhang, Zichao Liu, Yanlei Hao, Yili Wu et al. · 2021 · Research Square
- p75-NGFR and TNFR1 Interact and Cooperate During the Sympathetic Nervous System DevelopmentKazusa Edamura · 2014
- EpilepsyGregory Barnes, Reet Sidhu, Roberto Tuchman · 2012 · Springer eBooks
- EpilepsyGregory Neal Barnes, Reet Sidhu, Roberto F. Tuchman · 2021 · Springer eBooks
- Eph ReceptorKwok‐On Lai, Nancy Y. Ip · 2012 · Springer eBooks
- EphrinsSreenivasulu Kilari, George Albert Wilkinson · 2011 · Wiley eBooks
- Eph ReceptorKwok‐On Lai, Nancy Y. Ip · 2017 · Springer eBooks
- EphrinsSreenivasulu Kilari, Sai Swetha Alladi, Harshavardhan Kenche · 2020 · Wiley eBooks
- The Emerging field of epigenetic editing: implication for translational purposes for diseases with developmental originMinglu Wang, X. Shawn Liu · 2023 · Elsevier eBooks
- Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor functionChao Chang, Sara L. Banerjee, Sung Soon Park, Xiaolei Zhang, David Cotnoir‐White, Muriel Desbois, Brock J. Grill, Artur Kania · 2023 · eLife
- Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor functionChao Chang, Sara L. Banerjee, Sung Soon Park, Xiaolei Zhang, David Cotnoir‐White, Muriel Desbois, Brock J. Grill, Artur Kania · 2023 · eLife
- Therapeutic approaches to imprinting diseasesHela Sassi, Léa Guerrini‐Rousseau, Jacques Grill, Étienne Rouleau · 2023 · Elsevier eBooks
- Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor functionChao Chang, Sara L. Banerjee, Sung Soon Park, Xiaolei Zhang, David Cotnoir‐White, Karla J. Opperman, Muriel Desbois, Brock J. Grill, Artur Kania · 2023 · eLife
- Dysregulation of Neuronal Activity‐Dependent Immediate Early Genes in a Mouse Model of Angelman SyndromeBhaskarjyoti Giri, Sagarika Das, Sudipta Jana, Nihar Ranjan Jana · 2025 · Journal of Neurochemistry
- Phenotyping iPSC-derived neurons from Angelman patients and partial rescue via JNK pathway inactivationValentina Alari, Clara Cambria, Chiara De Cesari, Alessandro Vimercati, M. Crippa, Sara Perego, Lidia Larizza, Ilaria Tonazzini, Flavia Antonucci, Silvia Russo · 2026 · Journal of Neurodevelopmental Disorders
- Members of the RhoA subfamily of GTPases suppress the stimulatory effect of the HPV E6 oncoprotein on the ubiquitin ligase E6APDaniela Eichbichler, Jasmin Jansen, Nadja Eulich, Florian Stengel, Martin Scheffner · 2026 · Scientific Reports
- RhoA/ROCK signaling as a potential convergent pathway in microbiota–gut–brain axis-related cognitive impairmentYang Cao, Xingquan Wu, Junjie Yao, Huijuan Lou, Yahui Sun, Jinglei Jiang, Ya Song, Xia Meng, Chenyang Du, Daichaozi Da et al. · 2026 · Frontiers in Neurology
- Aberrant accumulation of α-synuclein might be linked with the progressive motor deficits in a mouse model of Angelman syndromeSagarika Das, Bhaskarjyoti Giri, Nihar Ranjan Jana · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Impaired Kv4.2-DPP6 complex dynamics in a mouse model of Angelman syndromeJia-Hua Hu, Ying Liu, Cole Malloy, Dax A. Hoffman · 2026 · Frontiers in Cellular Neuroscience