Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways

van Wageningen, Sake, Kemmeren, Patrick, Lijnzaad, Philip, Margaritis, Thanasis, Benschop, Joris J., de Castro, Inês J., van Leenen, Dik, Groot Koerkamp, Marian J.A. +17 more·2010·Cell
DOI 10.1016/j.cell.2010.11.021

Cited by (133)

Items 101–133 of 133

  1. Attenuation of transcriptional and signaling responses limits viability of ρ0Saccharomyces cerevisiae during periods of glucose deprivation
    R. Magnus N. Friis, Michael C. Schultz · 2016 · Biochimica et Biophysica Acta (BBA) - General Subjects
  2. Analyzing the Structure, Function and Information Flow in Signaling Networks using Quantitative Cellular Signatures
    Meghana M. Kulkarni, Norbert Perrimon · 2012 · Elsevier eBooks
  3. Exposing Contingency Plans for Kinase Networks
    Aileen M Klein, Elhadji M. Dioum, Melanie H. Cobb · 2010 · Cell
  4. Subgroup-specific gene expression profiles and mixed epistasis in chronic lymphocytic leukemia
    Almut Luetge, Junyan Lu, Jennifer Hüllein, Tatjana Walther, Leopold Sellner, Bian Wu, Richard Rosenquist, Christopher C. Oakes, Sascha Dietrich, Wolfgang K. Huber et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  5. Extending the Lymphoblastoid Cell Line Model for Drug Combination Pharmacogenomics
    Adrian J. Green, Benedict Anchang, Farida S. Akhtari, David M. Reif, Alison A. Motsinger‐Reif · 2021 · Pharmacogenomics
  6. Systematic inference of indirect transcriptional regulation by protein kinases and phosphatases
    Christian Degnbol Madsen, Jotun Hein, Christopher Thomas Workman · 2022 · PLoS Computational Biology
  7. SLDR: a computational technique to identify novel genetic regulatory relationships
    Zongliang Yue, Ping Wan, Hui Huang, Zhan Xie, Jake Y. Chen · 2014 · BMC Bioinformatics
  8. Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation
    Saman Amini, Frank C. P. Holstege, Patrick Kemmeren · 2017 · PLoS ONE
  9. A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans
    Phoebe Y. T. Lu, Alyssa C. Kirlin, Maria J. Aristizabal, Hilary T. Brewis, Nancy Lévesque, Dheva Setiaputra, Nikita Avvakumov, Joris J. Benschop, Marian J.A. Groot Koerkamp, Frank C. P. Holstege et al. · 2022 · Genetics
  10. Gene Duplication and Functional Consequences
    Xun Gu, Yangyun Zou, Zhixi Su · 2012 · Translational bioinformatics
  11. As we come to the end of 2011, several members of the Genome Biology Editorial Board give their views on the state of play in genomics
    David Adams, Bonnie Berger, Olivier Harismendy, Curtis Huttenhower, Shirley X. Liu, Chad L. Myers, Alicia Oshlack, John L. Rinn, Albertha J.M. Walhout · 2011 · Genome biology
  12. Modulation of the adipogenic master regulator PPARγ
    Ismayil Taşdelen · 2014 · Utrecht University Repository (Utrecht University)
  13. A dataset to explore kinase control of environmental stress responsive transcription
    Kieran Mace, Joanna Krakowiak, Hana El‐Samad, David Pincus · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Potent and lasting seizure suppression by systemic delivery of antagomirs targeting miR-134 timed with blood-brain barrier disruption
    Cristina Ruedell Reschke, Luiz Fernando Almeida Silva, Vamshidhar R. Vangoor, M. Rosso, Bastian David, Brenton Cavanagh, Niamh M. C. Connolly, Gerard P. Brennan, Amaya Sanz‐Rodriguez, Catherine Mooney et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Epigenetic reactivation of a neurodevelopmental phosphoprotein program in pituitary adenomas
    Prashant Chittiboina, Dustin Mullaney, Shyama Bhatt, Debjani Mandal, Diana Nwokoye, Stefan Stoica, Dhruval Bhatt, Kory R. Johnson, Abdel G. Elkhaloun, Christopher H. Dampier et al. · 2024 · Research Square
  16. Computational Identification of De-Centric Genetic Regulatory Relationships from Functional Genomic Data
    Zongliang Yue, Ping Wan, Zhan Xie, Jake Y. Chen · 2014 · Lecture notes in computer science
  17. Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling
    Richelle Sopko, Norbert Perrimon · 2015 · Elsevier eBooks
  18. Biochemical and functional analysis of TBP-containing complexes
    Gianpiero Spedale · 2011 · Utrecht University Repository (Utrecht University)
  19. Az anyagcsere szerkezetének hatása a genetikai interakciókra és a genomszerveződésre
    Károly Kovács · 2013
  20. A Systems Approach for Dissecting Integrated Signaling Pathways: TORC1 and Ras/PKA Regulation of Glucose Induced Growth Control in S. cerevisiae
    Joseph G. Kunkel · 2015 · UA Campus Repository (The University of Arizona)
  21. Coordination of MAP Kinase Signaling During Cell Fate Decisions
    Michal J. Nagiec · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  22. Investigation of budding yeast signaling transmission and integration by high-throughput quantitative mass spectrometry
    Stefania Vaga · 2013 · Repository for Publications and Research Data (ETH Zurich)
  23. The Design and Use of a High throughput Microscopy Screen to Monitor Transcription Factor Localization in Saccharomyces cerevisiae
    Michael John Cox · 2014 · TSpace (University of Toronto)
  24. Global Analysis of Kinase Interactions in Budding Yeast using Synthetic Dosage Lethality
    Sara Sharifpoor · 2012 · TSpace (University of Toronto)
  25. Systematic inference of regulation by protein kinases finds surprising level of transcription factor deactivation
    Christian Degnbol Madsen, Jotun Hein, Christopher Thomas Workman · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Faculty Opinions recommendation of Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.
    Eytan Ruppin, Sanju Sinha · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  27. Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling
    Richelle Sopko, Norbert Perrimon · 2016 · Elsevier eBooks
  28. New GO-based measures in multiple network alignment
    Kimia Yazdani, Reza Mousapour, Wayne B. Hayes · 2024 · Bioinformatics
  29. Prospects of Value Addition in Veggies: A Tool to Minimize Postharvest Losses
    Muhammad Nadeem, Zafar Iqbal, Tahir Mahmood Qureshi, Mian N. Riaz, Muhammad Adnan Shahid · 2025 · Springer eBooks
  30. Phosphoproteomic dysregulation drives tumor proliferation in Cushing’s disease
    David T. Asuzu, Dhruval Bhatt, Dustin Mullaney, Debjani Mandal, Diana Nwokoye, Sheelu Varghese, Daniela Tortoza Lopez, Nikhil Ramavenkat, Kory Johnson, Abdel Elkahloun et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Additional file 2 of A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers
    Tonći Šuštić, van Wageningen, Sake, Evert Bosdriesz, Robert J. D. Reid, John C. Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F.A. Wessels, Rodney J. Rothstein, René Bernards · 2018 · Figshare
  32. Phosphoproteomic dysregulation promotes tumor proliferation in Cushing’s disease
    David T. Asuzu, Dhruval Bhatt, Dustin Mullaney, Debjani Mandal, Diana Nwokoye, Sheelu Varghese, Daniela Tortoza Lopez, Nikhil Ramavenkat, Kory R. Johnson, Abdel G. Elkahloun et al. · 2026 · Proceedings of the National Academy of Sciences
  33. Pathway-Level Convergence of T Cell Programs in Pancreatic Cancer Revealed by Single-Cell Transcriptomics
    Simo Zhang · 2026 · International Conference on Bioinformatics and Biomedical Technology (ICBBT)