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Selective Translation of Leaderless mRNAs by Specialized Ribosomes Generated by MazF in Escherichia coli
Open accessAbstract
Summary Escherichia coli (E. coli) mazEF is a stress-induced toxin-antitoxin (TA) module. The toxin MazF is an endoribonuclease that cleaves single-stranded mRNAs at ACA sequences. Here, we show that MazF cleaves at ACA sites at or closely upstream of the AUG start codon of some specific mRNAs and thereby generates leaderless mRNAs. Moreover, we provide evidence that MazF also targets 16S rRNA within 30S ribosomal subunits at the decoding center, thereby removing 43 nucleotides from the 3′ terminus. As this region comprises the anti-Shine-Dalgarno (aSD) sequence that is required for translation initiation on canonical mRNAs, a subpopulation of ribosomes is formed that selectively translates the described leaderless mRNAs both in vivo and in vitro. Thus, we have discovered a modified translation machinery that is generated in response to MazF induction and that probably serves for stress adaptation in Escherichia coli.
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Cites
Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA
Woodcock, J., Moazed, D., Cannon, M., Davies, J., & Noller, H. F. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07863.x · Cited by 229
Cited by
One core, two shells: bacterial and eukaryotic ribosomes
Melnikov, S., Ben-Shem, A., Garreau de Loubresse, N., Jenner, L., Yusupova, G., & Yusupov, M. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2313 · Cited by 477
Cortes, T., Schubert, O. T., Rose, G., Arnvig, K. B., Comas, I., Aebersold, R., & Young, D. B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.031 · Cited by 310
Shell, S. S., Wang, J., Lapierre, P., Mir, M., Chase, M. R., Pyle, M. M., Gawande, R., Ahmad, R., Sarracino, D. A., Ioerger, T. R., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005641 · Cited by 238
Gebetsberger, J., Wyss, L., Mleczko, A. M., Reuther, J., & Polacek, N. (2017) · RNA Biology · doi:10.1080/15476286.2016.1257470 · Cited by 222
The bacterial translation stress response.
Starosta, A. L., Lassak, J., Jung, K., & Wilson, D. N. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12083 · Cited by 210
Metadata
- Authors
- Vesper, O., Amitai, S., Belitsky, M., Byrgazov, K., Kaberdina, A. C., Engelberg-Kulka, H., & Moll, I.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 147
- Issue
- 1
- Pages
- 147-157
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2108888559
- Cited by
- 292
- References
- 1
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vesper, O., Amitai, S., Belitsky, M., Byrgazov, K., Kaberdina, A. C., Engelberg-Kulka, H., & Moll, I. (2011). Selective Translation of Leaderless mRNAs by Specialized Ribosomes Generated by MazF in Escherichia coli. Cell. https://doi.org/10.1016/j.cell.2011.07.047
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