Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, Paul A., Katafuchi, Takeshi, Bookout, Angie L., Choi, Jang Hyun, Yu, Ruth T., Mangelsdorf, David J., Kliewer, Steven A.·2012·Cell

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  13. Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet
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  14. PPARγ sumoylation-mediated lipid accumulation in lung cancer
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  15. Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet
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  18. MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity
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  19. Nutritional regulation of fibroblast growth factor 21: from macronutrients to bioactive dietary compounds
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  20. Dynamic folding modulation generates FGF21 variant against diabetes
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  26. Adiponectin—a mediator of specific metabolic actions of FGF21
    Regina M. Goetz · 2013 · Nature Reviews Endocrinology
  27. Comparative microarray analyses of mono(2-ethylhexyl)phthalate impacts on fat cell bioenergetics and adipokine network
    Huai-Chih Chiang, Chih-Hong Wang, Szu‐Ching Yeh, Yi-Hua Lin, Ya-Ting Kuo, Chih-Wei Liao, Feng‐Yuan Tsai, Wei-Yu Lin, Wen-Han Chuang, Tsui‐Chun Tsou · 2017 · Cell Biology and Toxicology
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    Li Qiang, Domenico Accili · 2012 · Cell
  29. Hepatic FGF21 production is increased in late pregnancy in the mouse
    Yingjun Cui, Sarah L. Giesy, Mahmoud Hassan, Kristen Davis, Shuhong Zhao, Yves R. Boisclair · 2014 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
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    Maryam Esfahani, Mostafa Baranchi, Mohammad Taghi Goodarzi · 2019 · Diabetes & Metabolic Syndrome Clinical Research & Reviews
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  49. The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression
    Yoon Seok Jung, Ji-Min Lee, Don‐Kyu Kim, Yong Soo Lee, Ki-Sun Kim, Yong‐Hoon Kim, Jina Kim, Myung‐Shik Lee, In‐Kyu Lee, Seong Heon Kim et al. · 2016 · PLoS ONE
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  54. Nutrigenomic Functions of PPARs in Obesogenic Environments
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  56. Sirt1 mediates the effects of a short-term high-fat diet on the heart
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  57. Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies1,2
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  58. PPARγ: Potential Therapeutic Target for Ailments Beyond Diabetes and its Natural Agonism
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  61. Negative regulation of eNOS-NO signaling by over-SUMOylation of PPARγ contributes to insulin resistance and dysfunction of vascular endothelium in rats
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  64. Fibroblast growth factor 21
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  66. Lipodystrophic Diabetes Mellitus: a Lesson for Other Forms of Diabetes?
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  68. The U-shaped relationship between fibroblast growth factor 21 and microvascular complication in type 2 diabetes mellitus
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  69. The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients
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  70. Adipose tissue contribution to plasma fibroblast growth factor 21 and fibroblast activation protein in obesity
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  73. Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study
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  74. Skeletal integration of energy homeostasis: Translational implications
    Beata Lecka‐Czernik, Clifford james Rosen · 2015 · Bone
  75. Effects of pioglitazone and fenofibrate co-administration on bone biomechanics and histomorphometry in ovariectomized rats
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  76. Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes
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  77. Genome-wide association study for circulating fibroblast growth factor 21 and 23
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  78. Fibroblast growth factor-21 as a novel metabolic factor for regulating thrombotic homeostasis
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  79. Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes
    Lisa Arnetz, Mozhgan Dorkhan, Michael Alvarsson, Kerstin Brismar, Neda Rajamand Ekberg · 2013 · Acta Diabetologica
  80. Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination
    Jiwon Lee, Dong Joo Yang, Syann Lee, Gary Douglas Hammer, Ki Woo Kim, Joel Keith Elmquist · 2016 · Scientific Reports
  81. Metabolic Regulation by Nuclear Receptors
    Sihao Liu, Michael Downes, Ronald M. Evans · 2015 · Springer eBooks
  82. The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis
    Weide Ma, Dianyuan Zhao, Fuchu He, Li Tang · 2019 · The Journal of Immunology
  83. SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis
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  84. Improvements in Exercise for Alzheimer’s Disease: Highlighting FGF21-Induced Cerebrovascular Protection
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  88. Attenuation of FGF21 signalling might aggravate the impairment of glucose homeostasis during the high sucrose diet induced transition from prediabetes to diabetes in WNIN/GR-Ob rats
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  89. Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome
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  90. Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity
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  92. Fibroblast growth factor 21 and prognosis of patients with cardiovascular disease: A meta-analysis
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  93. Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression
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