Personal omics profiling reveals dynamic molecular and medical phenotypes

Chen, Rui, Mias, George I., Li-Pook-Than, Jennifer, Jiang, Lihua, Lam, Hugo Y.K., Chen, Rong, Miriami, Elana, Karczewski, Konrad J. +33 more·2012·Cell
DOI 10.1016/j.cell.2012.02.009

Cited by (999)

Items 801–900 of 999

  1. 404-Error “Disease Not Found”: Unleashing the Translational Potential of -Omics Approaches Beyond Traditional Disease Classification in Heart Failure Research
    Antonio Esquivel-Gaytan, Nils Bömer, Niels Grote Beverborg, Peter van der Meer · 2024 · European Journal of Heart Failure
  2. Decoding herbal medicine: AI-powered omics and network pharmacology
    Pu Wu, Lin Chen, Yu-Xin Xu, Yingying Ren, Xue-Man Dong, Jia-Xue Fan, Tian Xie, Jian‐Liang Zhou, Zhaoqian Liu · 2025 · Phytomedicine
  3. Artificial Intelligence in genomics: a comprehensive survey of methods, resources, challenges, and prospects
    Md Ishtyaq Mahmud, Tania Banerjee · 2026 · Briefings in Bioinformatics
  4. The evolution of personalized medicine: publications review
    Maksim Yu. Rykov · 2022 · Problems of Social Hygiene Public Health and History of Medicine
  5. A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants
    Chonghao Wang, Jing Zhang, Werner Pieter Veldsman, Xin Zhou, Lu Zhang · 2022 · Briefings in Bioinformatics
  6. Serial Sampling of the Small Airway Epithelium to Identify Persistent Smoking-dysregulated Genes
    Yael Strulovici‐Barel, Mahboubeh R. Rostami, Robert J. Kaner, Jason G. Mezey, Ronald G. Crystal · 2023 · American Journal of Respiratory and Critical Care Medicine
  7. A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy
    Qiongrong Huang, Zhiyuan Hu, Qiwen Zheng, Xuemei Mao, Wenxi Lv, Fei Wu, Dapeng Fu, Cuihong Lu, Changqing Zeng, Fei Wang et al. · 2024 · Phenomics
  8. A systems analysis of age-related changes in some cardiac aging traits
    Diddahally R. Govindaraju, Karol Mateusz Pencina, D. S. Raj, Joseph M. Massaro, Bruce A. Carnes, Ralph B. D’Agostino · 2013 · Biogerontology
  9. Specific Plasma Autoantibody Reactivity in Myelodysplastic Syndromes
    George I. Mias, Rui Chen, Yan Zhang, Kunju Joshi Sridhar, Donald Sharon, Xiao Li, Hogune Im, Michael P. Snyder, Peter L. Greenberg · 2013 · Scientific Reports
  10. Multiplexed protein detection using an affinity aptamer amplification assay
    Kris P. F. Janssen, Karel Knez, Dragana Spasić, Jan Schrooten, Jeroen Lammertyn · 2012 · Analytical and Bioanalytical Chemistry
  11. Metabolomics Integrated with Transcriptomics Reveals a Subtle Liver Metabolic Risk in Dairy Cows Fed Different Crop By‐products
    Hui‐Zeng Sun, D.M. Wang, Hongyun Liu, Jianxin Liu · 2018 · PROTEOMICS
  12. Next-Generation Sequencing: Technology, Advancements, and Applications
    Gourja Bansal, Kiran Narta, Manoj Ramesh Teltumbade · 2018 · Springer eBooks
  13. Impacts of circulating microRNAs in exercise-induced vascular remodeling
    Gary P. Van Guilder, Claudia C. Preston, Thayne A. Munce, Randolph S. Faustino · 2021 · American Journal of Physiology-Heart and Circulatory Physiology
  14. Using Big Data
    Nigam Haresh Shah · 2014 · Health informatics
  15. Applications of comparative evolution to human disease genetics
    Claire D. McWhite, Benjamin J. Liebeskind, Edward M. Marcotte · 2015 · Current Opinion in Genetics & Development
  16. Pediatric systems medicine: evaluating needs and opportunities using congenital heart block as a case study
    Jesper N. Tegner, Imad Abugessaisa · 2013 · Pediatric Research
  17. Genome sequencing for healthy individuals
    Saskia C. Sanderson · 2013 · Trends in Genetics
  18. Genetic and Epigenetic Regulation in Age-Related Macular Degeneration
    Lai Wei, Ping Chen, Joo Hyun Lee, Robert Burton Nussenblatt · 2013 · Asia-Pacific Journal of Ophthalmology
  19. The uncertain road towards genomic medicine
    Daniel G. MacArthur, Monkol Lek · 2012 · Trends in Genetics
  20. Knowledge and awareness on personalised medicine amongst medical students: A cross-sectional survey
    AneesAhmed Sindi, Sarah T. Altayyari, AnoudR Omer, HassanA Aljifri, Bashair Magadmi, AmiraA Nemri, MohammedA Basheikh · 2017 · Journal of health specialties
  21. integRATE: a desirability-based data integration framework for the prioritization of candidate genes across heterogeneous omics and its application to preterm birth
    Haley R. Eidem, J. Steenwyk, Jennifer H. Wisecaver, J. Capra, P. Abbot, A. Rokas · 2018 · BMC Medical Genomics
  22. The healthy core metabolism: A new paradigm for primary preventive nutrition
    Anthony Fardet, Edmond Rock · 2015 · The journal of nutrition health & aging
  23. PRECISION MEDICINE: DATA AND DISCOVERY FOR IMPROVED HEALTH AND THERAPY
    Alexander A. Morgan, Dana C. Crawford, Joshua C. Denny, Sean David Mooney, Bruce J. Aronow, Steven E. Brenner · 2016 · Pacific Symposium on Biocomputing (PSB)
  24. Should Psychiatry Be Precise? Reduction, Big Data, and Nosological Revision in Mental Health Research
    Kathryn Tabb · 2020 · Cambridge University Press eBooks
  25. The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
    J. Rozowsky, Jia-Hao Gao, Beatrice Borsari, Yucheng T. Yang, Timur R. Galeev, Gamze Gursoy, C. Epstein, Kun Xiong, Jin-Rui Xu, Tian-Xiao Li et al. · 2022 · bioRxiv
  26. Multi-omics and deep learning provide a multifaceted view of cancer
    Bora Uyar, Jonathan Ronen, Vedran Franke, Gaetano Gargiulo, Altuna Akalin · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Beyond Low Earth Orbit: Biomonitoring, Artificial Intelligence, and Precision Space Health
    Ryan T. Scott, Erik Antonsen, Sanders, Lauren M., Jaden J. A. Hastings, Seung-min Park, Graham Mackintosh, Robert J. Reynolds, Adrienne Hoarfrost, Aenor Sawyer, Casey S. Greene et al. · 2021 · White Rose Research Online (University of Leeds, The University of Sheffield, University of York)
  28. Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis
    Sai Zhang, Fereshteh Jahanbani, Varuna Chander, Martin Kjellberg, Menghui Liu, Katherine A. Glass, David S. Iu, Faraz Ahmed, Han Li, Rajan Douglas Maynard et al. · 2025 · medRxiv
  29. Technological advances transforming rheumatology
    William H. Robinson, Rong Mao · 2015 · Nature Reviews Rheumatology
  30. Evaluating Common Humoral Responses against Fungal Infections with Yeast Protein Microarrays
    Paulo S. R. Coelho, Hogune Im, Karl V. Clemons, Michael P. Snyder, David A. Stevens · 2015 · Journal of Proteome Research
  31. Challenges for Healthcare Administration and Delivery
    Linda A. Winters-Miner, Pat S. Bolding, Joseph M. Hilbe, Mitchell Goldstein, Thomas Hill, Robert Nisbet, Nephi Walton, Gary D. Miner · 2014 · Elsevier eBooks
  32. Clinical Perspectives in Diagnostic-omics and Personalized Medicine Approach to Monitor Effectiveness and Toxicity of Phytocomplexes
    Alessandro Buriani, Stefano Fortinguerra, Maria Carrara · 2017 · Springer eBooks
  33. A Cloud-Based Metabolite and Chemical Prioritization System for the Biology/Disease-Driven Human Proteome Project
    Kun‐Hsing Yu, Michael T. Lee, Yu‐Ju Chen, Christopher Ré, Samuel C. Kou, Jung-Hsien Chiang, Michael P. Snyder, Isaac S. Kohane · 2018 · Journal of Proteome Research
  34. Integrated, data-driven health management: A step closer to personalized and predictive healthcare
    Joseph Powell, Xiao Li · 2022 · Cell Systems
  35. Systems Biology of COVID-19 and Human Diseases: Beyond a Bird's Eye View, and Toward One Health
    Srishti Banerjee, Shreyayukta Chakraborty, Sandipan Ray · 2022 · OMICS A Journal of Integrative Biology
  36. Interpretation of personal genome sequencing data in terms of disease ranks based on mutual information
    Young-Ji Na, Kyung-Ah Sohn, Ju Han Kim · 2015 · BMC Medical Genomics
  37. Patient-centered drug discovery as the means to improved R&D productivity
    Araz A. Raoof, Jeroen Aerssens · 2015 · Drug Discovery Today
  38. Genomics and world health: a decade on
    Tikki Pang, David John Weatherall · 2012 · The Lancet
  39. Knowledge and Awareness on Personalized Medicine amongst Health Care Specialists and University Students in Health Colleges in Saudi Arabia
    Nehad Jaser Ahmed, Abdulrahman S. Alrawili, Faisal Z. Alkhawaja · 2020 · Journal of Pharmaceutical Research International
  40. Personalized evaluation based on quantitative proteomics for drug-treated patients with chronic kidney disease
    Qingrun Li, Wan-Jia Chen, Juwen Shen, Yi Can Wu, Rong-Xia Li, Yifei Zhong, Rong Zeng, Yueyi Deng · 2016 · Journal of Molecular Cell Biology
  41. 2012 highlights in translational 'omics
    Charles Auffray, Timothy Caulfield, Muin J. Khoury, James R. Lupski, Matthias Georg Schwab, Timothy D. Veenstra · 2013 · Genome Medicine
  42. Comment on “The Predictive Capacity of Personal Genome Sequencing”
    Eric J. Topol · 2012 · Science Translational Medicine
  43. Omics-driven startups challenge healthcare model
    Cormac Sheridan · 2015 · Nature Biotechnology
  44. Interpreting noncoding genetic variation in complex traits and human disease
    Ward, Lucas D, Kellis, Manolis · 2012 · Nature Biotechnology
  45. Targeted protein identification, quantification and reporting for high-resolution nanoflow targeted peptide monitoring
    Johannes A. Hewel, Sadhna Phanse, Jian Liu, Nicolas Bousette, Anthony O. Gramolini, Andrew Emili · 2012 · Journal of Proteomics
  46. d-StructMAn: Containerized structural annotation on the scale from genetic variants to whole proteomes
    Alexander Greß, Sanjay Kumar Srikakulam, Sebastian Keller, Vasily E. Ramensky, Olga V. Kalinina · 2022 · GigaScience
  47. Personalized medicine: current trends and prospects
    Igor S. Dolgopolov, Maksim Yu. Rykov · 2022 · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
  48. Personalized Medicine Approach to Proteomics and Metabolomics of Cytochrome P450 Enzymes: A Narrative Review
    John Fetse, Emmanuel Oladayo Olawode, Subrata Deb · 2024 · European Journal of Drug Metabolism and Pharmacokinetics
  49. Striving for clarity in language about gene expression
    Ana S.G. Cunningham, Myriam Gorospe · 2024 · Nucleic Acids Research
  50. Unravelling disease complexity: integrative analysis of multi-omic data in clinical research
    Ornella Cominetti, Loı̈c Dayon · 2025 · Expert Review of Proteomics
  51. In silico detection of phylogenetic informative Y‐chromosomal single nucleotide polymorphisms from whole genome sequencing data
    Anneleen Van Geystelen, Tom Wenseleers, Ronny Decorte, Maarten Caspers, Maarten Larmuseau · 2014 · Electrophoresis
  52. Personal Dense Dynamic Data Clouds Connect Systems Biomedicine to Scientific Wellness
    Gilbert S. Omenn, Andrew T. Magis, Nathan D. Price, Leroy Hood · 2022 · Methods in molecular biology
  53. Temporal response characterization across individual multiomics profiles of prediabetic and diabetic subjects
    Minzhang Zheng, Carlo Piermarocchi, George I. Mias · 2022 · Scientific Reports
  54. Mass Spectrometric Blood Metabogram: Acquisition, Characterization, and Prospects for Application
    Petr G. Lokhov, Elena E. Balashova, Oxana P. Trifonova, Dmitry L. Maslov, Anatoly I. Grigoriev, Elena A. Ponomarenko, Alexander I. Archakov · 2023 · International Journal of Molecular Sciences
  55. Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation
    Konrad Buscher, Rebecca Rixen, Paula Schütz, Birte Hüchtmann, Veerle Van Marck, Barbara Heitplatz, Ulrich Jehn, Daniela Anne Braun, Gert Gabriëls, Hermann Josef Pavenstädt et al. · 2023 · Translational research
  56. Q & A: the Snyderome
    Michael P. Snyder · 2012 · Genome biology
  57. Wake-up call by breathomics in sleep apnoea
    Peter J. Sterk, Niki Fens, Giovanna Elisiana Carpagnano · 2013 · European Respiratory Journal
  58. Nutrigenetics and Nutrigenomics
    Lynnette Robyn Ferguson · 2013 · CRC Press eBooks
  59. Operationalizing Precision Cardiovascular Medicine
    Jessica Wang, Jamil Aboulhosn, Ira S. Hofer, Aman Mahajan, Yibin Wang, Thomas M. Vondriska · 2016 · Circulation Research
  60. Genomics and Systems Biology Approaches in the Study of Lipid Disorders
    Alejandra Rodríguez, Päivi Pajukanta · 2018 · Revista de investigaci�n Cl�nica
  61. The Guangzhou Twin Eye Study: 2019 Update
    Xiaohu Ding, Wei Wang, Jane Scheetz, Mingguang He · 2019 · Twin Research and Human Genetics
  62. Identification of Hub Genes and Potential Molecular Mechanisms in Patients with HBV-Associated Acute Liver Failure
    Ying Sun, Haitao Yu, Fangfang Li, Liqiang Lan, Daxin He, Haijun Zhao, Dachuan Qi · 2020 · Evolutionary Bioinformatics
  63. SpliceJumper: a classification-based approach for calling splicing junctions from RNA-seq data
    Chong Chu, Xin Li, Yufeng Wu · 2015 · BMC Bioinformatics
  64. Future platforms for toxicity testing
    Mary T. McBride · 2017 · International Journal of Risk Assessment and Management
  65. NMR-Based Metabolic Profiling Procedures for Biofluids and Cell and Tissue Extracts
    Dimitra C. Benaki, Emmanuel Mikros · 2018 · Methods in molecular biology
  66. Reducing INDEL calling errors in whole-genome and exome sequencing data
    Han Fang, Yiyang Wu, Giuseppe Narzisi, Jason A. O’Rawe, Laura T. Jimenez Barrón, Julie Rosenbaum, Michael Ronemus, Ivan Iossifov, Michael C. Schatz, Gholson J. Lyon · 2014 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients
    Mitchell J. Cohen, Christopher B. Erickson, Ian S. LaCroix, Margot DeBot, Monika Dzieciątkowska, Sanchayita Mitra, Terry R. Schaid, William Morgan Hallas, Otto N. Thielen, Alexis L. Cralley et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Multi‐Omics Biomarkers From Variant to Clinic: A Systematic Review and Meta‐Analysis of Evidence, AI/ML, Governance, Equity, and Real‐World Implementation Across Global Health Systems
    Neelam Das · 2026 · Health Science Reports
  69. Perceiving Human Psychological Consistency: Attack Detection Against Advanced Persistent Social Engineering
    Kota Numada, Shinnosuke Nozaki, Takumi Takaiwa, Tetsushi Ohki, Masakatsu Nishigaki · 2024 · Lecture notes on data engineering and communications technologies
  70. Genomics and Proteomics: How Long Do We Need to Reach Clinical Results?
    Vittoria Matafora, Angela Bachi, Giovambattista Capasso · 2013 · Blood Purification
  71. Assessing Knowledge, Awareness, and Attitudes Towards Personalised, Genomic, and Pharmacogenomics Medicine in Health Students at Umm Al-Qura University: A Cross-Sectional Study
    Salah Bakry, Mohammad Ujaimi, Talal Alharthi, Ammar Alsufyani, Hammam Alsharif, Sulten Al-Zahrani, Ahmad H. Mufti · 2022 · Saudi Medical Horizons Journal
  72. Personalized Medicine for the Critically Ill Patient: A Narrative Review
    Alexandra Elena Lazăr, Leonard Azamfirei · 2022 · Processes
  73. Modeling Clinical Phenotype Variability: Consideration of Genomic Variations, Computational Methods, and Quantitative Proteomics
    Jane P. F. Bai, Li‐Rong Yu · 2022 · Journal of Pharmaceutical Sciences
  74. Clinical Blood Metabogram: Application to Overweight and Obese Patients
    Petr G. Lokhov, Elena E. Balashova, Oxana P. Trifonova, Dmitry L. Maslov, Oksana A. Plotnikova, Sharafetdinov KhKh, Dmitry Borisovich Nikityuk, Victor A. Tutelyan, Elena A. Ponomarenko, Alexander I. Archakov · 2023 · Metabolites
  75. Intuitive Web-Based Experimental Design for High-Throughput Biomedical Data
    Andreas Friedrich, Erhan Kenar, Oliver Kohlbacher, Sven Nahnsen · 2015 · BioMed Research International
  76. CorSig: A General Framework for Estimating Statistical Significance of Correlation and Its Application to Gene Co-Expression Analysis
    Hongqiang Wang, Chung‐Jui Tsai · 2013 · PLoS ONE
  77. Enhancing systems medicine beyond genotype data by dynamic patient signatures: having information and using it too
    Frank Emmert‐Streib, Matthias Dehmer · 2013 · Frontiers in Genetics
  78. Cystic fibrosis in the era of genomic medicine
    Carlos E. Milla · 2013 · Current Opinion in Pediatrics
  79. Applications of systems approaches in the study of rheumatic diseases
    Ki‐Jo Kim, Saseong Lee, Wan‐Uk Kim · 2015 · The Korean Journal of Internal Medicine
  80. Large-scale correlation mining for biomolecular network discovery
    Alfred O. Hero, Bala Rajaratnam · 2015 · Cambridge University Press eBooks
  81. Toward More Transparent and Reproducible Omics Studies Through a Common Metadata Checklist and Data Publications
    Eugene Kolker, Vural Özdemir, Lennart Martens, William S. Hancock, Gordon Anderson, Nathaniel Anderson, Şükrü Aynacıoğlu, Ancha V. Baranova, Shawn Robert Campagna, Rui Chen et al. · 2013 · Big Data
  82. Revealing Prognosis-Related Pathways at the Individual Level by a Comprehensive Analysis of Different Cancer Transcription Data
    Jingya Fang, Cong Pian, Mingmin Xu, Lingpeng Kong, Zutan Li, Jinwen Ji, Yuanyuan Chen, Liangyun Zhang · 2020 · Genes
  83. Exploring Innovation with Scientific Thinking
    De‐Pei Liu · 2022 · Chinese Medical Sciences Journal
  84. Bioinformatics strategies for studying the molecular mechanisms of fungal extracellular vesicles with a focus on infection and immune responses
    Kandasamy Saravanakumar, Sugavaneswaran Siva Santosh, MohamedAli Afaan Ahamed, Anbazhagan Sathiyaseelan, Ghazala Sultan, Irfan Navabshan, Davoodbasha MubarakAli, Myeong‐Hyeon Wang · 2022 · Briefings in Bioinformatics
  85. Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study
    Hong Li, Liu Li, Qiu-Qing Huang, Si-Yao Yang, Junju Zou, Fan Xiao, Xiang Qin, Xiu Liu, Rong Yu · 2024 · World Journal of Diabetes
  86. HARNESSING BIG DATA FOR PRECISION MEDICINE: INFRASTRUCTURES AND APPLICATIONS
    Kun‐Hsing Yu, Steven N. Hart, Rachel L. Goldfeder, Qiangfeng Cliff Zhang, Stephen C.J. Parker, Michael P. Snyder · 2016 · Pacific Symposium on Biocomputing (PSB)
  87. Multimodal Dynamic Profiling of Healthy and Diseased States for Future Personalized Health Care
    George I. Mias, Michael P. Snyder · 2012 · Clinical Pharmacology & Therapeutics
  88. Working Towards Personalization of Medicine: Genomics in 2014
    George P. Patrinos, Barbara Prainsack · 2014 · Personalized Medicine
  89. From Pharmacogenomics to Integrated Personal Omics Profiling: a Gap in Implementation into Healthcare
    Carsten Carlberg, Hannu Raunio · 2014 · Personalized Medicine
  90. Applications of Metabolomics in Reproductive Biology
    Ana Luiza Malhado Cazaux de Souza Velho, Rodrigo Vasconcelos de Oliveira, Thu T. N. Dinh, Arlindo A. Moura, Abdullah Kaya, Erdoğan Memili · 2017
  91. High Frequency Actionable Pathogenic Exome Mutations in an Average-Risk Cohort
    Shannon Rego, O. Dagan-Rosenfeld, Wenyu Zhou, M. Sailani, Patricia Limcaoco, Elizabeth Colbert, Monika Avina, J. Wheeler, Colleen M. Craig, Denis Salins et al. · 2017 · bioRxiv
  92. Introduction
    Donna L. Dickenson, B.C. van Beers, Sigrid Sterckx · 2018 · Cambridge University Press eBooks
  93. The Molecular Human – A Roadmap of Molecular Interactions Linking Multiomics Networks with Disease Endpoints
    Anna Halama, Shaza B. Zaghlool, Gaurav Thareja, Sara Abdul Kader, Wadha Al Muftha, Marjonneke J. Mook-Kanamori, Hina Sarwath, Yasmin Ali Mohamoud, Sabine Ameling, Maja Pučić‐Baković et al. · 2022 · medRxiv
  94. Multi-omics insights into uric acid metabolism in cardiometabolic disease: from genetics to metabolomics
    Nurshad Ali · 2026 · Biomedical Journal
  95. Identification of potential shared core biomarkers in type 2 diabetes and sarcopenia
    Ping Zhang, Yijun Du, Xing Zhong, Yue Wang, Tianrong Pan · 2025 · Scientific Reports
  96. Systems Pharmacology: Enabling Multidimensional Therapeutics
    Stuart R. Maudsley, Hanne Leysen, Jaana van Gastel, Bronwen Martin · 2021 · Elsevier eBooks
  97. Holo-omic applications to unveil microbiome shaping sustainable horticultural production
    Mohamed Ait-El-Mokhtar, Marouane Baslam · 2023 · Frontiers in Sustainable Food Systems
  98. Identification of potential pathogenic genes related to osteoporosis and osteoarthritis
    Zhanchao Wang, Wei J. Wang, Bin Zuo, Hua Lu · 2024 · Technology and Health Care
  99. NMR-based metabolomics: global analysis of metabolites to address problems in prostate cancer
    Matthew J. Roberts, Horst Joachim Schirra, Martin Francis Lavin, Robert Alexander Gardiner · 2014
  100. Delsa Workshop IV: Launching the Quantified Human Initiative
    Elizabeth Stewart, Todd Smith, Andrea G. De Souza, Jack Faris, Lennart Martens, Sophie Mohin, Vural Özdemir, Courtney MacNealy-Koch, Eugene Kolker · 2013 · Big Data